Tags

Type your tag names separated by a space and hit enter

Is preoperative serum prostate-specific antigen level significantly related to clinical recurrence after radical retropubic prostatectomy for localized prostate cancer?
BJU Int. 2006 Jan; 97(1):51-5.BI

Abstract

OBJECTIVE

To evaluate the influence of preoperative serum prostate-specific antigen (PSA) level and other clinicopathological variables on the probability of biochemical failure and clinical recurrence after radical prostatectomy (RP) for localized prostate cancer.

PATIENTS AND METHODS

The study was a retrospective survival analysis in 211 patients undergoing retropubic RP for clinically localized prostate cancer in the period 1988-2000. Survival was estimated using the Kaplan-Meier method; survival endpoints were biochemical failure, defined as a PSA level of > or = 0.5 ng/mL or clinical recurrence consisting of palpable tumours in the prostatic fossa or distant metastases. In 58 patients with biochemical failure after surgery, we assessed the impact of the doubling time of serum PSA level (PSADT) on the risk of developing skeletal metastases or local recurrence.

RESULTS

The median (range) observation period was 66 (9-160) months. Biochemical failure occurred in 92 patients (44%) of whom 39 (42%) had local recurrence or skeletal metastases. There was a highly significant association (P < 0.001) between clinical T stage, histological grade, capsular penetration, surgical margin status, seminal vesicle invasion, preoperative serum PSA level and the probability of biochemical failure-free survival. By contrast there was no statistically significant association between preoperative serum PSA level, clinical T stage, surgical margin status, and clinical recurrence. There was a significant relationship between age (P = 0.021), histological grade (P = 0.025), capsular penetration (P = 0.018), seminal vesicle invasion (P = 0014), and clinical recurrence. Cox regression analysis showed that only histological grade and seminal vesicle invasion were independent predictors of clinical recurrence. In a subgroup of 58 patients with a rising serum PSA level after RP, a PSADT of < or = 12.8 months conferred a significantly higher risk (P = 0.015) of developing skeletal metastases than a PSADT of >12.8 months.

CONCLUSION

In the present patients undergoing RP the preoperative serum PSA level was not associated with the clinical outcome, whereas it was significantly related to biochemical failure rate. The probability of skeletal metastases was significantly associated with the PSADT after biochemical failure.

Authors+Show Affiliations

Department of Surgical Sciences, University of Bergen, Bergen, Norway. svein.haukaas@kir.uib.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16336328

Citation

Haukaas, Svein A., et al. "Is Preoperative Serum Prostate-specific Antigen Level Significantly Related to Clinical Recurrence After Radical Retropubic Prostatectomy for Localized Prostate Cancer?" BJU International, vol. 97, no. 1, 2006, pp. 51-5.
Haukaas SA, Halvorsen OJ, Daehlin L, et al. Is preoperative serum prostate-specific antigen level significantly related to clinical recurrence after radical retropubic prostatectomy for localized prostate cancer? BJU Int. 2006;97(1):51-5.
Haukaas, S. A., Halvorsen, O. J., Daehlin, L., Hostmark, J., & Akslen, L. A. (2006). Is preoperative serum prostate-specific antigen level significantly related to clinical recurrence after radical retropubic prostatectomy for localized prostate cancer? BJU International, 97(1), 51-5.
Haukaas SA, et al. Is Preoperative Serum Prostate-specific Antigen Level Significantly Related to Clinical Recurrence After Radical Retropubic Prostatectomy for Localized Prostate Cancer. BJU Int. 2006;97(1):51-5. PubMed PMID: 16336328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is preoperative serum prostate-specific antigen level significantly related to clinical recurrence after radical retropubic prostatectomy for localized prostate cancer? AU - Haukaas,Svein A, AU - Halvorsen,Ole J, AU - Daehlin,Lars, AU - Hostmark,Jens, AU - Akslen,Lars A, PY - 2005/12/13/pubmed PY - 2006/1/24/medline PY - 2005/12/13/entrez SP - 51 EP - 5 JF - BJU international JO - BJU Int. VL - 97 IS - 1 N2 - OBJECTIVE: To evaluate the influence of preoperative serum prostate-specific antigen (PSA) level and other clinicopathological variables on the probability of biochemical failure and clinical recurrence after radical prostatectomy (RP) for localized prostate cancer. PATIENTS AND METHODS: The study was a retrospective survival analysis in 211 patients undergoing retropubic RP for clinically localized prostate cancer in the period 1988-2000. Survival was estimated using the Kaplan-Meier method; survival endpoints were biochemical failure, defined as a PSA level of > or = 0.5 ng/mL or clinical recurrence consisting of palpable tumours in the prostatic fossa or distant metastases. In 58 patients with biochemical failure after surgery, we assessed the impact of the doubling time of serum PSA level (PSADT) on the risk of developing skeletal metastases or local recurrence. RESULTS: The median (range) observation period was 66 (9-160) months. Biochemical failure occurred in 92 patients (44%) of whom 39 (42%) had local recurrence or skeletal metastases. There was a highly significant association (P < 0.001) between clinical T stage, histological grade, capsular penetration, surgical margin status, seminal vesicle invasion, preoperative serum PSA level and the probability of biochemical failure-free survival. By contrast there was no statistically significant association between preoperative serum PSA level, clinical T stage, surgical margin status, and clinical recurrence. There was a significant relationship between age (P = 0.021), histological grade (P = 0.025), capsular penetration (P = 0.018), seminal vesicle invasion (P = 0014), and clinical recurrence. Cox regression analysis showed that only histological grade and seminal vesicle invasion were independent predictors of clinical recurrence. In a subgroup of 58 patients with a rising serum PSA level after RP, a PSADT of < or = 12.8 months conferred a significantly higher risk (P = 0.015) of developing skeletal metastases than a PSADT of >12.8 months. CONCLUSION: In the present patients undergoing RP the preoperative serum PSA level was not associated with the clinical outcome, whereas it was significantly related to biochemical failure rate. The probability of skeletal metastases was significantly associated with the PSADT after biochemical failure. SN - 1464-4096 UR - https://www.unboundmedicine.com/medline/citation/16336328/Is_preoperative_serum_prostate_specific_antigen_level_significantly_related_to_clinical_recurrence_after_radical_retropubic_prostatectomy_for_localized_prostate_cancer L2 - https://doi.org/10.1111/j.1464-410X.2006.05886.x DB - PRIME DP - Unbound Medicine ER -