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Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys.
Exp Neurol. 2006 Feb; 197(2):275-83.EN

Abstract

It has been established that neuroinflammation is present in the substantia nigra (SN) of Parkinson disease (PD) cases but the factors responsible are as yet unknown. One contributing protein may be the intercellular adhesion molecule-1 (ICAM-1, CD54). ICAM-1 with its counter receptor, the lymphocyte function-associated antigen 1 (LFA-1) is known to play a key role in inflammatory processes and in T-cell mediated host defense mechanisms. We detected large numbers of ICAM-1-positive reactive astrocytes in the SN of a series of 14 patients with neuropathologically confirmed PD, including 3 of familial origin, compared with 11 age-matched controls. In PD SN, these ICAM-1-positive reactive astrocytes were particularly concentrated around many residual neurons in areas of heavy neuronal loss and extracellular melanin accumulation. LFA-1-positive reactive microglia gathered in areas of intense ICAM-1 expression, and LFA-1-positive leukocytes were identified infiltrating the tissue. Double immunostaining for ICAM-1 and LFA-1 revealed aggregates of reactive microglia embedded in areas of diffuse ICAM-1. Leukocyte counts were 5 fold higher in PD SN compared to controls (P < 0.001). Similar over-expression of ICAM-1 was found in monkeys that had been exposed to MPTP from 5.5 to 14 years previously compared with control monkeys. The presence of ICAM-1-positive reactive astrocytes in Parkinson disease and MPTP-treated monkeys is indicative of a sustained inflammatory process and suggests that antiinflammatory agents may have a place in PD therapy.

Authors+Show Affiliations

Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T1Z3.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16336966

Citation

Miklossy, J, et al. "Role of ICAM-1 in Persisting Inflammation in Parkinson Disease and MPTP Monkeys." Experimental Neurology, vol. 197, no. 2, 2006, pp. 275-83.
Miklossy J, Doudet DD, Schwab C, et al. Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys. Exp Neurol. 2006;197(2):275-83.
Miklossy, J., Doudet, D. D., Schwab, C., Yu, S., McGeer, E. G., & McGeer, P. L. (2006). Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys. Experimental Neurology, 197(2), 275-83.
Miklossy J, et al. Role of ICAM-1 in Persisting Inflammation in Parkinson Disease and MPTP Monkeys. Exp Neurol. 2006;197(2):275-83. PubMed PMID: 16336966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys. AU - Miklossy,J, AU - Doudet,D D, AU - Schwab,C, AU - Yu,S, AU - McGeer,E G, AU - McGeer,P L, Y1 - 2005/12/05/ PY - 2005/04/28/received PY - 2005/08/25/revised PY - 2005/10/17/accepted PY - 2005/12/13/pubmed PY - 2006/4/4/medline PY - 2005/12/13/entrez SP - 275 EP - 83 JF - Experimental neurology JO - Exp Neurol VL - 197 IS - 2 N2 - It has been established that neuroinflammation is present in the substantia nigra (SN) of Parkinson disease (PD) cases but the factors responsible are as yet unknown. One contributing protein may be the intercellular adhesion molecule-1 (ICAM-1, CD54). ICAM-1 with its counter receptor, the lymphocyte function-associated antigen 1 (LFA-1) is known to play a key role in inflammatory processes and in T-cell mediated host defense mechanisms. We detected large numbers of ICAM-1-positive reactive astrocytes in the SN of a series of 14 patients with neuropathologically confirmed PD, including 3 of familial origin, compared with 11 age-matched controls. In PD SN, these ICAM-1-positive reactive astrocytes were particularly concentrated around many residual neurons in areas of heavy neuronal loss and extracellular melanin accumulation. LFA-1-positive reactive microglia gathered in areas of intense ICAM-1 expression, and LFA-1-positive leukocytes were identified infiltrating the tissue. Double immunostaining for ICAM-1 and LFA-1 revealed aggregates of reactive microglia embedded in areas of diffuse ICAM-1. Leukocyte counts were 5 fold higher in PD SN compared to controls (P < 0.001). Similar over-expression of ICAM-1 was found in monkeys that had been exposed to MPTP from 5.5 to 14 years previously compared with control monkeys. The presence of ICAM-1-positive reactive astrocytes in Parkinson disease and MPTP-treated monkeys is indicative of a sustained inflammatory process and suggests that antiinflammatory agents may have a place in PD therapy. SN - 0014-4886 UR - https://www.unboundmedicine.com/medline/citation/16336966/Role_of_ICAM_1_in_persisting_inflammation_in_Parkinson_disease_and_MPTP_monkeys_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4886(05)00373-0 DB - PRIME DP - Unbound Medicine ER -