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The P300 component in patients with Alzheimer's disease and their biological children.
Biol Psychol. 2006 May; 72(2):180-7.BP

Abstract

OBJECTIVE

There are few studies examining P300 in the biological children of patients with Alzheimer's disease (AD). In addition to examining P300 in patients with AD, the current study examined the utility of P300 as a preclinical marker in the offspring of AD patients.

METHODS

P300 was elicited from an AD group, their biological children, and two age- and gender-matched control groups using the auditory oddball paradigm. Each group consisted of 20 subjects each. ERPs recorded from sites Fz, Cz, and Pz were analysed using analysis of variance.

RESULTS

Amplitudes were significantly smaller in the AD group when compared to controls. Both amplitude and latency values in the FH+ group were significantly impaired when compared to its control group.

CONCLUSION

These findings replicate previous P300 amplitude abnormalities found in patients with AD. Further, participants with a family history of AD demonstrate possible preclinical evidence at the electrophysiological level. Comparisons with other findings and theoretical implications are discussed.

Authors+Show Affiliations

Harvard Medical School and New England GRECC, Geriatric Neuropsychology Laboratory, USA. bally@bu.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16337071

Citation

Ally, Brandon A., et al. "The P300 Component in Patients With Alzheimer's Disease and Their Biological Children." Biological Psychology, vol. 72, no. 2, 2006, pp. 180-7.
Ally BA, Jones GE, Cole JA, et al. The P300 component in patients with Alzheimer's disease and their biological children. Biol Psychol. 2006;72(2):180-7.
Ally, B. A., Jones, G. E., Cole, J. A., & Budson, A. E. (2006). The P300 component in patients with Alzheimer's disease and their biological children. Biological Psychology, 72(2), 180-7.
Ally BA, et al. The P300 Component in Patients With Alzheimer's Disease and Their Biological Children. Biol Psychol. 2006;72(2):180-7. PubMed PMID: 16337071.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The P300 component in patients with Alzheimer's disease and their biological children. AU - Ally,Brandon A, AU - Jones,Gary E, AU - Cole,Jack A, AU - Budson,Andrew E, Y1 - 2005/12/05/ PY - 2005/05/03/received PY - 2005/09/07/revised PY - 2005/10/12/accepted PY - 2005/12/13/pubmed PY - 2006/9/9/medline PY - 2005/12/13/entrez SP - 180 EP - 7 JF - Biological psychology JO - Biol Psychol VL - 72 IS - 2 N2 - OBJECTIVE: There are few studies examining P300 in the biological children of patients with Alzheimer's disease (AD). In addition to examining P300 in patients with AD, the current study examined the utility of P300 as a preclinical marker in the offspring of AD patients. METHODS: P300 was elicited from an AD group, their biological children, and two age- and gender-matched control groups using the auditory oddball paradigm. Each group consisted of 20 subjects each. ERPs recorded from sites Fz, Cz, and Pz were analysed using analysis of variance. RESULTS: Amplitudes were significantly smaller in the AD group when compared to controls. Both amplitude and latency values in the FH+ group were significantly impaired when compared to its control group. CONCLUSION: These findings replicate previous P300 amplitude abnormalities found in patients with AD. Further, participants with a family history of AD demonstrate possible preclinical evidence at the electrophysiological level. Comparisons with other findings and theoretical implications are discussed. SN - 0301-0511 UR - https://www.unboundmedicine.com/medline/citation/16337071/The_P300_component_in_patients_with_Alzheimer's_disease_and_their_biological_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-0511(05)00167-5 DB - PRIME DP - Unbound Medicine ER -