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Bioassay-guided evaluation of anti-inflammatory and antinociceptive activities of pistachio, Pistacia vera L.
J Ethnopharmacol. 2006 Apr 21; 105(1-2):235-40.JE

Abstract

The ethanolic and aqueous extracts prepared from different parts of Pistacia vera L. (Anacardiaceae) as well as its oleoresin were evaluated for their in vivo anti-inflammatory and antinociceptive activities. Among the extracts screened, only the oleoresin was shown to possess a marked anti-inflammatory activity against carrageenan-induced hind paw edema model in mice without inducing any gastric damage at both 250 and 500 mg/kg doses whereas the rest of the extracts were totally inactive. While the oleoresin was found to display significant antinociceptive activity at 500 mg/kg dose, the ethanolic and aqueous extracts belonging to fruit, leaf, branch and peduncle of Pistacia vera did not exhibit any noticeable antinociception in p-benzoquinone-induced abdominal contractions in mice. Fractionation of the oleoresin indicated the n-hexane fraction to be active, which further led to recognition of some monoterpenes, mainly alpha-pinene (77.5%) by capillary gas chromatography-mass spectrometry (GC-MS) as well as the oleoresin itself. alpha-Pinene was also assessed for its antinociceptive and anti-inflammatory activities in the same manner and exerted a moderate anti-inflammatory effect at 500 mg/kg dose.

Authors+Show Affiliations

Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 06330, Ankara, Turkey. iorhan@gazi.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16337351

Citation

Orhan, I, et al. "Bioassay-guided Evaluation of Anti-inflammatory and Antinociceptive Activities of Pistachio, Pistacia Vera L." Journal of Ethnopharmacology, vol. 105, no. 1-2, 2006, pp. 235-40.
Orhan I, Küpeli E, Aslan M, et al. Bioassay-guided evaluation of anti-inflammatory and antinociceptive activities of pistachio, Pistacia vera L. J Ethnopharmacol. 2006;105(1-2):235-40.
Orhan, I., Küpeli, E., Aslan, M., Kartal, M., & Yesilada, E. (2006). Bioassay-guided evaluation of anti-inflammatory and antinociceptive activities of pistachio, Pistacia vera L. Journal of Ethnopharmacology, 105(1-2), 235-40.
Orhan I, et al. Bioassay-guided Evaluation of Anti-inflammatory and Antinociceptive Activities of Pistachio, Pistacia Vera L. J Ethnopharmacol. 2006 Apr 21;105(1-2):235-40. PubMed PMID: 16337351.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioassay-guided evaluation of anti-inflammatory and antinociceptive activities of pistachio, Pistacia vera L. AU - Orhan,I, AU - Küpeli,E, AU - Aslan,M, AU - Kartal,M, AU - Yesilada,E, Y1 - 2005/12/06/ PY - 2005/07/29/received PY - 2005/10/25/revised PY - 2005/10/31/accepted PY - 2005/12/13/pubmed PY - 2006/12/23/medline PY - 2005/12/13/entrez SP - 235 EP - 40 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 105 IS - 1-2 N2 - The ethanolic and aqueous extracts prepared from different parts of Pistacia vera L. (Anacardiaceae) as well as its oleoresin were evaluated for their in vivo anti-inflammatory and antinociceptive activities. Among the extracts screened, only the oleoresin was shown to possess a marked anti-inflammatory activity against carrageenan-induced hind paw edema model in mice without inducing any gastric damage at both 250 and 500 mg/kg doses whereas the rest of the extracts were totally inactive. While the oleoresin was found to display significant antinociceptive activity at 500 mg/kg dose, the ethanolic and aqueous extracts belonging to fruit, leaf, branch and peduncle of Pistacia vera did not exhibit any noticeable antinociception in p-benzoquinone-induced abdominal contractions in mice. Fractionation of the oleoresin indicated the n-hexane fraction to be active, which further led to recognition of some monoterpenes, mainly alpha-pinene (77.5%) by capillary gas chromatography-mass spectrometry (GC-MS) as well as the oleoresin itself. alpha-Pinene was also assessed for its antinociceptive and anti-inflammatory activities in the same manner and exerted a moderate anti-inflammatory effect at 500 mg/kg dose. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/16337351/Bioassay_guided_evaluation_of_anti_inflammatory_and_antinociceptive_activities_of_pistachio_Pistacia_vera_L_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(05)00743-9 DB - PRIME DP - Unbound Medicine ER -