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NMDA receptor antagonists antagonize the facilitatory effects of post-training intra-basolateral amygdala NMDA and physostigmine on passive avoidance learning.
Eur J Pharmacol. 2006 Jan 04; 529(1-3):122-8.EJ

Abstract

In the present study, the effects of post-training intra-basolateral amygdala (BLA) injection of an N-methyl-d-aspartate (NMDA) receptor agonist and competitive or noncompetitive antagonists, on memory retention of passive avoidance learning was measured in the presence and absence of physostigmine in rats. Intra-BLA administration of lower doses of NMDA (10(-5) and 10(-4) microg/rat) did not affect memory retention, although higher doses of the drug (10(-3), 10(-2) and 10(-1) microg/rat) increased memory retention. The greatest response was obtained with 10(-1) microg/rat of the drug. The different doses of the competitive NMDA receptor antagonist DL-AP5 (1, 3.2 and 10 microg/rat) and noncompetitive NMDA receptor antagonist MK-801 (0.5, 1 and 2 microg/rat) decreased memory retention in rats dose dependently. Both competitive and noncompetitive NMDA receptor antagonists reduced the effect of NMDA (10(-2) microg/rat). In another series of experiments, intra-BLA injection of physostigmine (2, 3 and 4 microg/rat) improved memory retention. Post-training co-administration of lower doses of NMDA (10(-5) and 10(-4) microg/rat) and physostigmine (1 microg/rat), doses which were ineffective when given alone, significantly improved the retention latency. The competitive and noncompetitive NMDA receptor antagonists, DL-AP5 and MK-801, decreased the effect of physostigmine (2 microg/rat). Atropine decreased memory retention by itself and potentiated the response to DL-AP5 and MK-801. It may be concluded that amygdalar NMDA receptor mechanisms interact with cholinergic systems in the modulation of memory.

Authors+Show Affiliations

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran. jafarisa@sina.tums.ac.ir

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16337625

Citation

Jafari-Sabet, Majid. "NMDA Receptor Antagonists Antagonize the Facilitatory Effects of Post-training Intra-basolateral Amygdala NMDA and Physostigmine On Passive Avoidance Learning." European Journal of Pharmacology, vol. 529, no. 1-3, 2006, pp. 122-8.
Jafari-Sabet M. NMDA receptor antagonists antagonize the facilitatory effects of post-training intra-basolateral amygdala NMDA and physostigmine on passive avoidance learning. Eur J Pharmacol. 2006;529(1-3):122-8.
Jafari-Sabet, M. (2006). NMDA receptor antagonists antagonize the facilitatory effects of post-training intra-basolateral amygdala NMDA and physostigmine on passive avoidance learning. European Journal of Pharmacology, 529(1-3), 122-8.
Jafari-Sabet M. NMDA Receptor Antagonists Antagonize the Facilitatory Effects of Post-training Intra-basolateral Amygdala NMDA and Physostigmine On Passive Avoidance Learning. Eur J Pharmacol. 2006 Jan 4;529(1-3):122-8. PubMed PMID: 16337625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - NMDA receptor antagonists antagonize the facilitatory effects of post-training intra-basolateral amygdala NMDA and physostigmine on passive avoidance learning. A1 - Jafari-Sabet,Majid, Y1 - 2005/12/07/ PY - 2005/04/25/received PY - 2005/10/18/revised PY - 2005/10/25/accepted PY - 2005/12/13/pubmed PY - 2006/3/10/medline PY - 2005/12/13/entrez SP - 122 EP - 8 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 529 IS - 1-3 N2 - In the present study, the effects of post-training intra-basolateral amygdala (BLA) injection of an N-methyl-d-aspartate (NMDA) receptor agonist and competitive or noncompetitive antagonists, on memory retention of passive avoidance learning was measured in the presence and absence of physostigmine in rats. Intra-BLA administration of lower doses of NMDA (10(-5) and 10(-4) microg/rat) did not affect memory retention, although higher doses of the drug (10(-3), 10(-2) and 10(-1) microg/rat) increased memory retention. The greatest response was obtained with 10(-1) microg/rat of the drug. The different doses of the competitive NMDA receptor antagonist DL-AP5 (1, 3.2 and 10 microg/rat) and noncompetitive NMDA receptor antagonist MK-801 (0.5, 1 and 2 microg/rat) decreased memory retention in rats dose dependently. Both competitive and noncompetitive NMDA receptor antagonists reduced the effect of NMDA (10(-2) microg/rat). In another series of experiments, intra-BLA injection of physostigmine (2, 3 and 4 microg/rat) improved memory retention. Post-training co-administration of lower doses of NMDA (10(-5) and 10(-4) microg/rat) and physostigmine (1 microg/rat), doses which were ineffective when given alone, significantly improved the retention latency. The competitive and noncompetitive NMDA receptor antagonists, DL-AP5 and MK-801, decreased the effect of physostigmine (2 microg/rat). Atropine decreased memory retention by itself and potentiated the response to DL-AP5 and MK-801. It may be concluded that amygdalar NMDA receptor mechanisms interact with cholinergic systems in the modulation of memory. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/16337625/NMDA_receptor_antagonists_antagonize_the_facilitatory_effects_of_post_training_intra_basolateral_amygdala_NMDA_and_physostigmine_on_passive_avoidance_learning_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(05)01098-8 DB - PRIME DP - Unbound Medicine ER -