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Ultraviolet B sensitivity of peripheral lymphocytes as an independent risk factor for cutaneous melanoma.
Eur J Cancer 2006; 42(2):212-5EJ

Abstract

Susceptibility to solar ultraviolet is an important melanoma risk factor. We investigated the relationship between individual susceptibility to ultraviolet and risk of melanoma by measuring the apoptosis triggered in peripheral lymphocytes by a low-dose ultraviolet B irradiation (50 J/m(2)) in young and older melanoma patients and controls. Melanoma patients below the age of 40 are more sensitive to UVB-induced apoptosis than older melanoma patients and healthy controls. Analysis of data (adjusted for age and phototype) shows that UVB-induced apoptosis is an important risk factor for melanoma (OR 9.1, 95% CI [3-28], P=0.0001). UVB-induced apoptosis is independent of phototype (P=0.11, Wald test) and tumour thickness (P=0.88, Spearman correlation, for all cases and 0.26 for patients younger than 40 years), and may be used as a functional laboratory test for studying the genetic-environment interactions involved in melanoma occurrence.

Authors+Show Affiliations

INSERM U 590, Lyon, France. remy.pedeux@ujf-grenoble.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16337788

Citation

Pedeux, Rémy, et al. "Ultraviolet B Sensitivity of Peripheral Lymphocytes as an Independent Risk Factor for Cutaneous Melanoma." European Journal of Cancer (Oxford, England : 1990), vol. 42, no. 2, 2006, pp. 212-5.
Pedeux R, Sales F, Pourchet J, et al. Ultraviolet B sensitivity of peripheral lymphocytes as an independent risk factor for cutaneous melanoma. Eur J Cancer. 2006;42(2):212-5.
Pedeux, R., Sales, F., Pourchet, J., Kallassy, M., Fayolle, C., Boniol, M., ... Doré, J. F. (2006). Ultraviolet B sensitivity of peripheral lymphocytes as an independent risk factor for cutaneous melanoma. European Journal of Cancer (Oxford, England : 1990), 42(2), pp. 212-5.
Pedeux R, et al. Ultraviolet B Sensitivity of Peripheral Lymphocytes as an Independent Risk Factor for Cutaneous Melanoma. Eur J Cancer. 2006;42(2):212-5. PubMed PMID: 16337788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ultraviolet B sensitivity of peripheral lymphocytes as an independent risk factor for cutaneous melanoma. AU - Pedeux,Rémy, AU - Sales,François, AU - Pourchet,Julie, AU - Kallassy,Mireille, AU - Fayolle,Caroline, AU - Boniol,Mathieu, AU - Severi,Gianluca, AU - Ghanem,Ghanem, AU - Nakazawa,Hisayoshi Nym, AU - Autier,Philippe, AU - Doré,Jean-François, Y1 - 2005/12/07/ PY - 2005/06/14/received PY - 2005/09/12/revised PY - 2005/09/15/accepted PY - 2005/12/13/pubmed PY - 2006/3/8/medline PY - 2005/12/13/entrez SP - 212 EP - 5 JF - European journal of cancer (Oxford, England : 1990) JO - Eur. J. Cancer VL - 42 IS - 2 N2 - Susceptibility to solar ultraviolet is an important melanoma risk factor. We investigated the relationship between individual susceptibility to ultraviolet and risk of melanoma by measuring the apoptosis triggered in peripheral lymphocytes by a low-dose ultraviolet B irradiation (50 J/m(2)) in young and older melanoma patients and controls. Melanoma patients below the age of 40 are more sensitive to UVB-induced apoptosis than older melanoma patients and healthy controls. Analysis of data (adjusted for age and phototype) shows that UVB-induced apoptosis is an important risk factor for melanoma (OR 9.1, 95% CI [3-28], P=0.0001). UVB-induced apoptosis is independent of phototype (P=0.11, Wald test) and tumour thickness (P=0.88, Spearman correlation, for all cases and 0.26 for patients younger than 40 years), and may be used as a functional laboratory test for studying the genetic-environment interactions involved in melanoma occurrence. SN - 0959-8049 UR - https://www.unboundmedicine.com/medline/citation/16337788/Ultraviolet_B_sensitivity_of_peripheral_lymphocytes_as_an_independent_risk_factor_for_cutaneous_melanoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0959-8049(05)00944-5 DB - PRIME DP - Unbound Medicine ER -