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The mononuclear phagocyte system.
Curr Opin Immunol. 2006 Feb; 18(1):49-53.CO

Abstract

The mononuclear phagocyte system (MPS) has been defined as a family of cells comprising bone marrow progenitors, blood monocytes and tissue macrophages. Macrophages are a major cell population in most of the tissues in the body, and their numbers increase further in inflammation, wounding and malignancy. Their trophic roles for other cell types in development and homeostasis are becoming increasingly evident. The receptor for macrophage colony-stimulating factor (CSF-1R) is expressed in a large proportion of cells considered to be mononuclear phagocytes, including antigen-presenting dendritic cells, which can be considered a specialized adaptive state rather than a separate lineage. The unity of the MPS is challenged by evidence that there is a separate embryonic phagocyte lineage, by the transdifferentiation and fusion of MPS cells with other cell types, and by evidence of local renewal of tissue macrophage populations as opposed to monocyte recruitment. The concept of the MPS may have partly outlived its usefulness.

Authors+Show Affiliations

Institute for Molecular Bioscience, University of Queensland, Q4072, Australia. D.Hume@imb.uq.edu.au

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16338128

Citation

Hume, David A.. "The Mononuclear Phagocyte System." Current Opinion in Immunology, vol. 18, no. 1, 2006, pp. 49-53.
Hume DA. The mononuclear phagocyte system. Curr Opin Immunol. 2006;18(1):49-53.
Hume, D. A. (2006). The mononuclear phagocyte system. Current Opinion in Immunology, 18(1), 49-53.
Hume DA. The Mononuclear Phagocyte System. Curr Opin Immunol. 2006;18(1):49-53. PubMed PMID: 16338128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The mononuclear phagocyte system. A1 - Hume,David A, Y1 - 2005/12/09/ PY - 2005/10/18/received PY - 2005/11/24/accepted PY - 2005/12/13/pubmed PY - 2006/3/4/medline PY - 2005/12/13/entrez SP - 49 EP - 53 JF - Current opinion in immunology JO - Curr Opin Immunol VL - 18 IS - 1 N2 - The mononuclear phagocyte system (MPS) has been defined as a family of cells comprising bone marrow progenitors, blood monocytes and tissue macrophages. Macrophages are a major cell population in most of the tissues in the body, and their numbers increase further in inflammation, wounding and malignancy. Their trophic roles for other cell types in development and homeostasis are becoming increasingly evident. The receptor for macrophage colony-stimulating factor (CSF-1R) is expressed in a large proportion of cells considered to be mononuclear phagocytes, including antigen-presenting dendritic cells, which can be considered a specialized adaptive state rather than a separate lineage. The unity of the MPS is challenged by evidence that there is a separate embryonic phagocyte lineage, by the transdifferentiation and fusion of MPS cells with other cell types, and by evidence of local renewal of tissue macrophage populations as opposed to monocyte recruitment. The concept of the MPS may have partly outlived its usefulness. SN - 0952-7915 UR - https://www.unboundmedicine.com/medline/citation/16338128/The_mononuclear_phagocyte_system_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-7915(05)00201-3 DB - PRIME DP - Unbound Medicine ER -