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Independent elevations of N-terminal pro-brain natriuretic peptide and cardiac troponins in endurance athletes after prolonged strenuous exercise.
Am Heart J. 2005 Dec; 150(6):1128-34.AH

Abstract

BACKGROUND

Although elevated resting brain natriuretic peptide (BNP) concentrations reflect heart disease, the meaning of exercise-induced increases is poorly understood and has been examined in small groups only. Therefore, the present study aimed to examine the increase in N-terminal pro-brain natriuretic peptide (NT-proBNP) and relations to cardiac troponin I and T (cTnI, cTnT) elevations after prolonged strenuous exercise in a large cohort of athletes.

METHODS

We examined exercise-induced changes in NT-proBNP, cTnI, and cTnT in 105 obviously healthy endurance athletes (40 +/- 8 years) before and after prolonged strenuous exercise. Blood samples were taken before, 15 minutes, and 3 hours after a marathon (n = 46), a 100-km run (n = 14), and a mountain bike marathon (n = 45).

RESULTS

Eighty-one of 105 athletes exceeded the upper reference limit of NT-proBNP (males/females 88:153 ng/L) after exercise. NT-proBNP increased in all 3 events (P < .001) with the highest increase in the 100-km runners (median increase 200 ng/L; 25th/75th percentile 115/770 ng/L), which differed from the increase in the marathon (97 ng/L; 36/254 ng/L) or the mountain bike marathon (78 ng/L; 37/196 ng/L) (P < .01). Cardiac troponin I exceeded 0.04 microg/L in 74%; cTnT exceeded 0.01 microg/L in 47% of athletes after exercise. NT-proBNP was not related to exercise-induced increases in cTnI or cTnT, but correlated with exercise time (r = 0.55, P < .001).

CONCLUSIONS

Increases in NT-proBNP can be found in a major part of obviously healthy athletes after prolonged strenuous exercise. The release of BNP during and after exercise may not result from myocardial damage but may have cytoprotective and growth-regulating effects. The different nature of exercise-induced increases in BNP and cardiac troponins has to be elucidated in the future.

Authors+Show Affiliations

Institute of Sports and Preventive Medicine, University of Saarland, Saarbrücken/Homburg, Germany. j.scharhag@mx.uni-saarland.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16338248

Citation

Scharhag, Jürgen, et al. "Independent Elevations of N-terminal Pro-brain Natriuretic Peptide and Cardiac Troponins in Endurance Athletes After Prolonged Strenuous Exercise." American Heart Journal, vol. 150, no. 6, 2005, pp. 1128-34.
Scharhag J, Herrmann M, Urhausen A, et al. Independent elevations of N-terminal pro-brain natriuretic peptide and cardiac troponins in endurance athletes after prolonged strenuous exercise. Am Heart J. 2005;150(6):1128-34.
Scharhag, J., Herrmann, M., Urhausen, A., Haschke, M., Herrmann, W., & Kindermann, W. (2005). Independent elevations of N-terminal pro-brain natriuretic peptide and cardiac troponins in endurance athletes after prolonged strenuous exercise. American Heart Journal, 150(6), 1128-34.
Scharhag J, et al. Independent Elevations of N-terminal Pro-brain Natriuretic Peptide and Cardiac Troponins in Endurance Athletes After Prolonged Strenuous Exercise. Am Heart J. 2005;150(6):1128-34. PubMed PMID: 16338248.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Independent elevations of N-terminal pro-brain natriuretic peptide and cardiac troponins in endurance athletes after prolonged strenuous exercise. AU - Scharhag,Jürgen, AU - Herrmann,Markus, AU - Urhausen,Axel, AU - Haschke,Michaela, AU - Herrmann,Wolfgang, AU - Kindermann,Wilfried, PY - 2004/11/02/received PY - 2005/01/05/accepted PY - 2005/12/13/pubmed PY - 2006/2/16/medline PY - 2005/12/13/entrez SP - 1128 EP - 34 JF - American heart journal JO - Am Heart J VL - 150 IS - 6 N2 - BACKGROUND: Although elevated resting brain natriuretic peptide (BNP) concentrations reflect heart disease, the meaning of exercise-induced increases is poorly understood and has been examined in small groups only. Therefore, the present study aimed to examine the increase in N-terminal pro-brain natriuretic peptide (NT-proBNP) and relations to cardiac troponin I and T (cTnI, cTnT) elevations after prolonged strenuous exercise in a large cohort of athletes. METHODS: We examined exercise-induced changes in NT-proBNP, cTnI, and cTnT in 105 obviously healthy endurance athletes (40 +/- 8 years) before and after prolonged strenuous exercise. Blood samples were taken before, 15 minutes, and 3 hours after a marathon (n = 46), a 100-km run (n = 14), and a mountain bike marathon (n = 45). RESULTS: Eighty-one of 105 athletes exceeded the upper reference limit of NT-proBNP (males/females 88:153 ng/L) after exercise. NT-proBNP increased in all 3 events (P < .001) with the highest increase in the 100-km runners (median increase 200 ng/L; 25th/75th percentile 115/770 ng/L), which differed from the increase in the marathon (97 ng/L; 36/254 ng/L) or the mountain bike marathon (78 ng/L; 37/196 ng/L) (P < .01). Cardiac troponin I exceeded 0.04 microg/L in 74%; cTnT exceeded 0.01 microg/L in 47% of athletes after exercise. NT-proBNP was not related to exercise-induced increases in cTnI or cTnT, but correlated with exercise time (r = 0.55, P < .001). CONCLUSIONS: Increases in NT-proBNP can be found in a major part of obviously healthy athletes after prolonged strenuous exercise. The release of BNP during and after exercise may not result from myocardial damage but may have cytoprotective and growth-regulating effects. The different nature of exercise-induced increases in BNP and cardiac troponins has to be elucidated in the future. SN - 1097-6744 UR - https://www.unboundmedicine.com/medline/citation/16338248/Independent_elevations_of_N_terminal_pro_brain_natriuretic_peptide_and_cardiac_troponins_in_endurance_athletes_after_prolonged_strenuous_exercise_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-8703(05)00218-8 DB - PRIME DP - Unbound Medicine ER -