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Changing perspectives in yeast research nearly a decade after the genome sequence.
Genome Res. 2005 Dec; 15(12):1611-9.GR

Abstract

Research with budding yeast (Saccharomyces cerevisiae) has been transformed by the publication, nearly a decade ago, of the entire genome DNA sequence. The introduction of this first eukaryotic genomic sequence changed the yeast research environment significantly, not just because of dramatic progress in technical means but also because the sequence made accessible a new class of scientific questions. A central goal of yeast research remains the determination of the biological role of every sequence feature in the yeast genome. The most remarkable change has been the shift in perspective from focus on individual genes and functionalities to a more global view of how the cellular networks and systems interact and function together to produce the highly evolved organism we see today.

Authors+Show Affiliations

Dolinski K
Lewis-Sigler Institute for Integrative Genomics, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 USA.
Botstein D
No affiliation info available

MeSH

DNA, FungalGene Expression ProfilingGenome, FungalResearchResearch DesignSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSequence Analysis, DNA

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16339358

Citation

Dolinski, Kara, and David Botstein. "Changing Perspectives in Yeast Research Nearly a Decade After the Genome Sequence." Genome Research, vol. 15, no. 12, 2005, pp. 1611-9.
Dolinski K, Botstein D. Changing perspectives in yeast research nearly a decade after the genome sequence. Genome Res. 2005;15(12):1611-9.
Dolinski, K., & Botstein, D. (2005). Changing perspectives in yeast research nearly a decade after the genome sequence. Genome Research, 15(12), 1611-9.
Dolinski K, Botstein D. Changing Perspectives in Yeast Research Nearly a Decade After the Genome Sequence. Genome Res. 2005;15(12):1611-9. PubMed PMID: 16339358.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changing perspectives in yeast research nearly a decade after the genome sequence. AU - Dolinski,Kara, AU - Botstein,David, PY - 2005/12/13/pubmed PY - 2006/2/18/medline PY - 2005/12/13/entrez SP - 1611 EP - 9 JF - Genome research JO - Genome Res VL - 15 IS - 12 N2 - Research with budding yeast (Saccharomyces cerevisiae) has been transformed by the publication, nearly a decade ago, of the entire genome DNA sequence. The introduction of this first eukaryotic genomic sequence changed the yeast research environment significantly, not just because of dramatic progress in technical means but also because the sequence made accessible a new class of scientific questions. A central goal of yeast research remains the determination of the biological role of every sequence feature in the yeast genome. The most remarkable change has been the shift in perspective from focus on individual genes and functionalities to a more global view of how the cellular networks and systems interact and function together to produce the highly evolved organism we see today. SN - 1088-9051 UR - https://www.unboundmedicine.com/medline/citation/16339358/Changing_perspectives_in_yeast_research_nearly_a_decade_after_the_genome_sequence_ DB - PRIME DP - Unbound Medicine ER -