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Comparison of efficacy of oral valacyclovir and topical acyclovir in the treatment of herpes simplex keratitis: a randomized clinical trial.
Chemotherapy. 2006; 52(1):29-31.C

Abstract

Thirty eyes of 28 patients with herpetic disease were included in the study. Group 1 patients (15 eyes of 15 subjects) received topical acyclovir (ACV) ointment. Oral valacyclovir (VACV) was prescribed to group 2 (15 eyes of 13 patients). The anterior segment of each eye was carefully examined by slit lamp and scored. Each patient was also instructed to grade his/her subjective symptoms. The corneal lesion healed significantly faster in the group 2 eyes compared to the group 1 eyes. Photophobia score on day 3 and slit-lamp score on day 10 were at significantly lower levels in group 2 compared to group 1. In herpetic keratitis, oral VACV can be a good alternative to ACV ointment therapy.

Authors+Show Affiliations

Department of Ophthalmology, Karadeniz Technical University, School of Medicine, Trabzon, Turkey.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16340195

Citation

Sozen, Engin, et al. "Comparison of Efficacy of Oral Valacyclovir and Topical Acyclovir in the Treatment of Herpes Simplex Keratitis: a Randomized Clinical Trial." Chemotherapy, vol. 52, no. 1, 2006, pp. 29-31.
Sozen E, Avunduk AM, Akyol N. Comparison of efficacy of oral valacyclovir and topical acyclovir in the treatment of herpes simplex keratitis: a randomized clinical trial. Chemotherapy. 2006;52(1):29-31.
Sozen, E., Avunduk, A. M., & Akyol, N. (2006). Comparison of efficacy of oral valacyclovir and topical acyclovir in the treatment of herpes simplex keratitis: a randomized clinical trial. Chemotherapy, 52(1), 29-31.
Sozen E, Avunduk AM, Akyol N. Comparison of Efficacy of Oral Valacyclovir and Topical Acyclovir in the Treatment of Herpes Simplex Keratitis: a Randomized Clinical Trial. Chemotherapy. 2006;52(1):29-31. PubMed PMID: 16340195.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of efficacy of oral valacyclovir and topical acyclovir in the treatment of herpes simplex keratitis: a randomized clinical trial. AU - Sozen,Engin, AU - Avunduk,Avni Murat, AU - Akyol,Nurettin, Y1 - 2005/12/09/ PY - 2004/12/28/received PY - 2005/06/20/accepted PY - 2005/12/13/pubmed PY - 2006/3/8/medline PY - 2005/12/13/entrez SP - 29 EP - 31 JF - Chemotherapy JO - Chemotherapy VL - 52 IS - 1 N2 - Thirty eyes of 28 patients with herpetic disease were included in the study. Group 1 patients (15 eyes of 15 subjects) received topical acyclovir (ACV) ointment. Oral valacyclovir (VACV) was prescribed to group 2 (15 eyes of 13 patients). The anterior segment of each eye was carefully examined by slit lamp and scored. Each patient was also instructed to grade his/her subjective symptoms. The corneal lesion healed significantly faster in the group 2 eyes compared to the group 1 eyes. Photophobia score on day 3 and slit-lamp score on day 10 were at significantly lower levels in group 2 compared to group 1. In herpetic keratitis, oral VACV can be a good alternative to ACV ointment therapy. SN - 0009-3157 UR - https://www.unboundmedicine.com/medline/citation/16340195/Comparison_of_efficacy_of_oral_valacyclovir_and_topical_acyclovir_in_the_treatment_of_herpes_simplex_keratitis:_a_randomized_clinical_trial_ L2 - https://www.karger.com?DOI=10.1159/000090239 DB - PRIME DP - Unbound Medicine ER -