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Alterations in serum levels of trace elements in tuberculosis and HIV infections.

Abstract

OBJECTIVE

To evaluate serum concentrations of trace elements in tuberculosis (TB) patients with or with out human immunodeficiency virus (HIV) coinfection before and after anti-TB chemotherapy.

SUBJECTS

A total of 155 TB patients, 74 of which were coinfected with HIV, and 31 healthy controls from Gondar, Ethiopia.

METHODS

Serum levels of copper, zinc, selenium and iron were determined using an inductively coupled plasma mass spectrometer from all subjects at baseline and from 44 TB patients (22 with HIV coinfection) at the end of an intensive phase of anti-TB chemotherapy.

RESULTS

Compared with the control group, the concentrations of iron, zinc and selenium were significantly lower (P<0.05) while that of copper and copper/zinc ratio was significantly higher (P<0.05) in the serum of TB patients. TB patients with HIV coinfection had significantly lower serum zinc and selenium concentrations and significantly higher copper/zinc ratio compared to that in TB patients without HIV coinfection (P<0.05). The serum concentration of zinc had significantly increased at the end of intensive phase of anti-TB chemotherapy in patients without HIV coinfection (P<0.05). An increase in serum selenium level was observed in TB patients with or without HIV coinfection after therapy. On the contrary, serum copper concentration and copper/zinc ratio declined significantly after anti-TB chemotherapy irrespective of HIV serostatus (P<0.05).

CONCLUSIONS

The results indicate that TB patients have altered profile of trace elements in their sera. This warrants the need for further investigations so that strategies for trace elements supplementation can be planned in addition to their potential as diagnostic parameters in monitoring responses to anti-TB chemotherapy.

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  • Authors+Show Affiliations

    ,

    Department of Preventive Environment and Nutrition, Systems of Nutritional Sciences, Graduate School of Health Biosciences Research, The University of Tokushima, Tokushima, Japan.

    , , , , , , , , , ,

    Source

    MeSH

    Adult
    Antitubercular Agents
    Copper
    Ethiopia
    Female
    HIV Infections
    Humans
    Iron
    Male
    Mass Spectrometry
    Nutritional Status
    Selenium
    Trace Elements
    Tuberculosis
    Zinc

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16340948

    Citation

    Kassu, A, et al. "Alterations in Serum Levels of Trace Elements in Tuberculosis and HIV Infections." European Journal of Clinical Nutrition, vol. 60, no. 5, 2006, pp. 580-6.
    Kassu A, Yabutani T, Mahmud ZH, et al. Alterations in serum levels of trace elements in tuberculosis and HIV infections. Eur J Clin Nutr. 2006;60(5):580-6.
    Kassu, A., Yabutani, T., Mahmud, Z. H., Mohammad, A., Nguyen, N., Huong, B. T., ... Ota, F. (2006). Alterations in serum levels of trace elements in tuberculosis and HIV infections. European Journal of Clinical Nutrition, 60(5), pp. 580-6.
    Kassu A, et al. Alterations in Serum Levels of Trace Elements in Tuberculosis and HIV Infections. Eur J Clin Nutr. 2006;60(5):580-6. PubMed PMID: 16340948.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alterations in serum levels of trace elements in tuberculosis and HIV infections. AU - Kassu,A, AU - Yabutani,T, AU - Mahmud,Z H, AU - Mohammad,A, AU - Nguyen,N, AU - Huong,B T M, AU - Hailemariam,G, AU - Diro,E, AU - Ayele,B, AU - Wondmikun,Y, AU - Motonaka,J, AU - Ota,F, PY - 2005/12/13/pubmed PY - 2006/6/9/medline PY - 2005/12/13/entrez SP - 580 EP - 6 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 60 IS - 5 N2 - OBJECTIVE: To evaluate serum concentrations of trace elements in tuberculosis (TB) patients with or with out human immunodeficiency virus (HIV) coinfection before and after anti-TB chemotherapy. SUBJECTS: A total of 155 TB patients, 74 of which were coinfected with HIV, and 31 healthy controls from Gondar, Ethiopia. METHODS: Serum levels of copper, zinc, selenium and iron were determined using an inductively coupled plasma mass spectrometer from all subjects at baseline and from 44 TB patients (22 with HIV coinfection) at the end of an intensive phase of anti-TB chemotherapy. RESULTS: Compared with the control group, the concentrations of iron, zinc and selenium were significantly lower (P<0.05) while that of copper and copper/zinc ratio was significantly higher (P<0.05) in the serum of TB patients. TB patients with HIV coinfection had significantly lower serum zinc and selenium concentrations and significantly higher copper/zinc ratio compared to that in TB patients without HIV coinfection (P<0.05). The serum concentration of zinc had significantly increased at the end of intensive phase of anti-TB chemotherapy in patients without HIV coinfection (P<0.05). An increase in serum selenium level was observed in TB patients with or without HIV coinfection after therapy. On the contrary, serum copper concentration and copper/zinc ratio declined significantly after anti-TB chemotherapy irrespective of HIV serostatus (P<0.05). CONCLUSIONS: The results indicate that TB patients have altered profile of trace elements in their sera. This warrants the need for further investigations so that strategies for trace elements supplementation can be planned in addition to their potential as diagnostic parameters in monitoring responses to anti-TB chemotherapy. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16340948/Alterations_in_serum_levels_of_trace_elements_in_tuberculosis_and_HIV_infections_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602352 DB - PRIME DP - Unbound Medicine ER -