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Oligofructose promotes satiety in healthy human: a pilot study.
Eur J Clin Nutr. 2006 May; 60(5):567-72.EJ

Abstract

OBJECTIVE

The administration of a fermentable dietary fibre (oligofructose) in rats increases satietogenic gut peptides and lowered spontaneous energy intake. The aim of the study was to assess the relevance of those effects of oligofructose on satiety and energy intake in humans.

DESIGN

Single-blinded, crossover, placebo-controlled design, pilot study.

SUBJECTS

Volunteers included five men and five women aged 21-39 years, BMI ranging from 18.5 to 27.4 kg/m(2), were randomly assigned as described below.

INTERVENTIONS

Subjects were included in two 2-week experimental phases during which they received either fibre (oligofructose (OFS)) or placebo (dextrine maltose (DM)); a 2-week washout period was included between crossover phases. In total, 8 g OFS or 8 g DM were ingested twice daily (16 g/day in total). Energy intake, hunger, satiety, fullness and prospective food consumption were assessed with analogue scales at the end of each experimental phase.

RESULTS

During breakfast, OFS significantly increases the satiety (P=0.04) without any difference on other sensations as compared to DM treatment periods. After lunch, no significant differences are observed between treatment period. At dinner, OFS significantly increases satiety (P=0.04), reduces hunger (P=0.04) and prospective food consumption (P=0.05). The energy intake at breakfast and lunch are significantly lower (P=0.01, 0.03, respectively) after OFS treatment than after DM treatment. Total energy intake per day is 5% lower during OFS than in DM period.

CONCLUSION

Oligofructose treatment increases satiety following breakfast and dinner, reduces hunger and prospective food consumption following dinner. This pilot study presents a rationale to propose oligofructose supplements in the management of food intake in overweight and obese patients.

Authors+Show Affiliations

Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Department of Pharmaceutical Sciences, Université catholique de Louvain, Brussels, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16340949

Citation

Cani, P D., et al. "Oligofructose Promotes Satiety in Healthy Human: a Pilot Study." European Journal of Clinical Nutrition, vol. 60, no. 5, 2006, pp. 567-72.
Cani PD, Joly E, Horsmans Y, et al. Oligofructose promotes satiety in healthy human: a pilot study. Eur J Clin Nutr. 2006;60(5):567-72.
Cani, P. D., Joly, E., Horsmans, Y., & Delzenne, N. M. (2006). Oligofructose promotes satiety in healthy human: a pilot study. European Journal of Clinical Nutrition, 60(5), 567-72.
Cani PD, et al. Oligofructose Promotes Satiety in Healthy Human: a Pilot Study. Eur J Clin Nutr. 2006;60(5):567-72. PubMed PMID: 16340949.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oligofructose promotes satiety in healthy human: a pilot study. AU - Cani,P D, AU - Joly,E, AU - Horsmans,Y, AU - Delzenne,N M, PY - 2005/12/13/pubmed PY - 2006/6/9/medline PY - 2005/12/13/entrez SP - 567 EP - 72 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 60 IS - 5 N2 - OBJECTIVE: The administration of a fermentable dietary fibre (oligofructose) in rats increases satietogenic gut peptides and lowered spontaneous energy intake. The aim of the study was to assess the relevance of those effects of oligofructose on satiety and energy intake in humans. DESIGN: Single-blinded, crossover, placebo-controlled design, pilot study. SUBJECTS: Volunteers included five men and five women aged 21-39 years, BMI ranging from 18.5 to 27.4 kg/m(2), were randomly assigned as described below. INTERVENTIONS: Subjects were included in two 2-week experimental phases during which they received either fibre (oligofructose (OFS)) or placebo (dextrine maltose (DM)); a 2-week washout period was included between crossover phases. In total, 8 g OFS or 8 g DM were ingested twice daily (16 g/day in total). Energy intake, hunger, satiety, fullness and prospective food consumption were assessed with analogue scales at the end of each experimental phase. RESULTS: During breakfast, OFS significantly increases the satiety (P=0.04) without any difference on other sensations as compared to DM treatment periods. After lunch, no significant differences are observed between treatment period. At dinner, OFS significantly increases satiety (P=0.04), reduces hunger (P=0.04) and prospective food consumption (P=0.05). The energy intake at breakfast and lunch are significantly lower (P=0.01, 0.03, respectively) after OFS treatment than after DM treatment. Total energy intake per day is 5% lower during OFS than in DM period. CONCLUSION: Oligofructose treatment increases satiety following breakfast and dinner, reduces hunger and prospective food consumption following dinner. This pilot study presents a rationale to propose oligofructose supplements in the management of food intake in overweight and obese patients. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16340949/Oligofructose_promotes_satiety_in_healthy_human:_a_pilot_study_ DB - PRIME DP - Unbound Medicine ER -