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Effects of administration of iron, iodine and simultaneous iron-plus-iodine on the thyroid hormone profile in iron-deficient adolescent Iranian girls.
Eur J Clin Nutr. 2006 Apr; 60(4):545-52.EJ

Abstract

OBJECTIVE

To investigate whether iron supplementation can improve thyroid hormone function in iron-deficient adolescent girls.

DESIGN

A double-blind randomized intervention study.

SETTING

The study was performed from 2002 through 2003 in the Islamic Republic of Iran.

SUBJECTS

103 iron-deficient non-anaemic girls who fulfilled all inclusion criteria were included, and 94 subjects successfully completed the study.

INTERVENTIONS

Patients were randomly assigned to one of four groups and treated with a single oral dose of 190 mg iodine plus 300 mg ferrous sulphate 5 times/week (n=24), 300 mg ferrous sulphate 5 times/week (n=23), a single oral dose of 190 mg iodine (n=25), or a placebo (n=22) for 12 weeks.

RESULTS

All groups were comparable at baseline. After the intervention, there was a significant increase in ferritin and transferrin saturation in the iron+iodine group (17.6 vs 8.7 microg/dl, and 18.8 vs 7.2%, respectively, P<0.001 for both) and in the iron group (P<0.001 for both). Urinary iodine doubled in the iron+iodine group and in the iodine group (P<0.001 for both). Thyroid indices tT4, tT3 and T3RU increased and reverse RT3 decreased in the iron+iodine group (10 vs 8.9 microg/dl, P< 0.001; 143 vs 138 microg/dl, P<0.05; 32.3 vs 28.4%, P<0.001 and 24.8 vs 44.2 ng/dl, P<0.001, respectively) and in the iron group. These two groups did not differ for any of the four indices, but both differed significantly from the iodine and placebo groups.

CONCLUSIONS

Our results indicate that improvement of iron status was accompanied by an improvement in some indices of thyroid hormones.

SPONSORSHIP

This study was supported by the Dean of Research Affairs of the Tehran University of Medical Sciences.

Authors+Show Affiliations

Department of Nutrition and Biochemistry, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Islamic Republic of Iran. h_eftekhari@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16340950

Citation

Eftekhari, M H., et al. "Effects of Administration of Iron, Iodine and Simultaneous Iron-plus-iodine On the Thyroid Hormone Profile in Iron-deficient Adolescent Iranian Girls." European Journal of Clinical Nutrition, vol. 60, no. 4, 2006, pp. 545-52.
Eftekhari MH, Simondon KB, Jalali M, et al. Effects of administration of iron, iodine and simultaneous iron-plus-iodine on the thyroid hormone profile in iron-deficient adolescent Iranian girls. Eur J Clin Nutr. 2006;60(4):545-52.
Eftekhari, M. H., Simondon, K. B., Jalali, M., Keshavarz, S. A., Elguero, E., Eshraghian, M. R., & Saadat, N. (2006). Effects of administration of iron, iodine and simultaneous iron-plus-iodine on the thyroid hormone profile in iron-deficient adolescent Iranian girls. European Journal of Clinical Nutrition, 60(4), 545-52.
Eftekhari MH, et al. Effects of Administration of Iron, Iodine and Simultaneous Iron-plus-iodine On the Thyroid Hormone Profile in Iron-deficient Adolescent Iranian Girls. Eur J Clin Nutr. 2006;60(4):545-52. PubMed PMID: 16340950.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of administration of iron, iodine and simultaneous iron-plus-iodine on the thyroid hormone profile in iron-deficient adolescent Iranian girls. AU - Eftekhari,M H, AU - Simondon,K B, AU - Jalali,M, AU - Keshavarz,S A, AU - Elguero,E, AU - Eshraghian,M R, AU - Saadat,N, PY - 2005/12/13/pubmed PY - 2006/6/9/medline PY - 2005/12/13/entrez SP - 545 EP - 52 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 60 IS - 4 N2 - OBJECTIVE: To investigate whether iron supplementation can improve thyroid hormone function in iron-deficient adolescent girls. DESIGN: A double-blind randomized intervention study. SETTING: The study was performed from 2002 through 2003 in the Islamic Republic of Iran. SUBJECTS: 103 iron-deficient non-anaemic girls who fulfilled all inclusion criteria were included, and 94 subjects successfully completed the study. INTERVENTIONS: Patients were randomly assigned to one of four groups and treated with a single oral dose of 190 mg iodine plus 300 mg ferrous sulphate 5 times/week (n=24), 300 mg ferrous sulphate 5 times/week (n=23), a single oral dose of 190 mg iodine (n=25), or a placebo (n=22) for 12 weeks. RESULTS: All groups were comparable at baseline. After the intervention, there was a significant increase in ferritin and transferrin saturation in the iron+iodine group (17.6 vs 8.7 microg/dl, and 18.8 vs 7.2%, respectively, P<0.001 for both) and in the iron group (P<0.001 for both). Urinary iodine doubled in the iron+iodine group and in the iodine group (P<0.001 for both). Thyroid indices tT4, tT3 and T3RU increased and reverse RT3 decreased in the iron+iodine group (10 vs 8.9 microg/dl, P< 0.001; 143 vs 138 microg/dl, P<0.05; 32.3 vs 28.4%, P<0.001 and 24.8 vs 44.2 ng/dl, P<0.001, respectively) and in the iron group. These two groups did not differ for any of the four indices, but both differed significantly from the iodine and placebo groups. CONCLUSIONS: Our results indicate that improvement of iron status was accompanied by an improvement in some indices of thyroid hormones. SPONSORSHIP: This study was supported by the Dean of Research Affairs of the Tehran University of Medical Sciences. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16340950/Effects_of_administration_of_iron_iodine_and_simultaneous_iron_plus_iodine_on_the_thyroid_hormone_profile_in_iron_deficient_adolescent_Iranian_girls_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602349 DB - PRIME DP - Unbound Medicine ER -