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Examination of seven candidate regions for multiple sclerosis: strong evidence of linkage to chromosome 1q44.
Genes Immun. 2006 Jan; 7(1):73-6.GI

Abstract

Multiple sclerosis (MS) is a debilitating neuroimmunological and neurodegenerative disease with a strong genetic component. Numerous studies have failed to consistently identify genes that confer disease susceptibility except for association with HLA-DR. Seven non-HLA regions (1q, 2q, 9q, 13q, 16q, 18p and 19q) identified in a recent genomic screen were investigated by genotyping approximately 20 single-nucleotide polymorphisms (SNPs) at approximately 1 Mb intervals. Non-parametric multipoint analyses identified a peak LOD* score of 2.99 for the 1q44 region and substantially narrowed the linkage peak to approximately 7 Mb. Ordered subset analyses (OSA) identified significant LOD score increases for 2q35 and 18p11 when ranking families by HLA-DR status and identified a significant LOD score increase in region 2q35 when ranking families by linkage to chromosome 1q44. 1q44 is particularly interesting because of linkage evidence for this region in studies of both rheumatoid arthritis and systemic lupus erythematosus.

Authors+Show Affiliations

Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232-0700, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16341055

Citation

Kenealy, S J., et al. "Examination of Seven Candidate Regions for Multiple Sclerosis: Strong Evidence of Linkage to Chromosome 1q44." Genes and Immunity, vol. 7, no. 1, 2006, pp. 73-6.
Kenealy SJ, Herrel LA, Bradford Y, et al. Examination of seven candidate regions for multiple sclerosis: strong evidence of linkage to chromosome 1q44. Genes Immun. 2006;7(1):73-6.
Kenealy, S. J., Herrel, L. A., Bradford, Y., Schnetz-Boutaud, N., Oksenberg, J. R., Hauser, S. L., Barcellos, L. F., Schmidt, S., Gregory, S. G., Pericak-Vance, M. A., & Haines, J. L. (2006). Examination of seven candidate regions for multiple sclerosis: strong evidence of linkage to chromosome 1q44. Genes and Immunity, 7(1), 73-6.
Kenealy SJ, et al. Examination of Seven Candidate Regions for Multiple Sclerosis: Strong Evidence of Linkage to Chromosome 1q44. Genes Immun. 2006;7(1):73-6. PubMed PMID: 16341055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Examination of seven candidate regions for multiple sclerosis: strong evidence of linkage to chromosome 1q44. AU - Kenealy,S J, AU - Herrel,L A, AU - Bradford,Y, AU - Schnetz-Boutaud,N, AU - Oksenberg,J R, AU - Hauser,S L, AU - Barcellos,L F, AU - Schmidt,S, AU - Gregory,S G, AU - Pericak-Vance,M A, AU - Haines,J L, PY - 2005/12/13/pubmed PY - 2009/2/24/medline PY - 2005/12/13/entrez SP - 73 EP - 6 JF - Genes and immunity JO - Genes Immun. VL - 7 IS - 1 N2 - Multiple sclerosis (MS) is a debilitating neuroimmunological and neurodegenerative disease with a strong genetic component. Numerous studies have failed to consistently identify genes that confer disease susceptibility except for association with HLA-DR. Seven non-HLA regions (1q, 2q, 9q, 13q, 16q, 18p and 19q) identified in a recent genomic screen were investigated by genotyping approximately 20 single-nucleotide polymorphisms (SNPs) at approximately 1 Mb intervals. Non-parametric multipoint analyses identified a peak LOD* score of 2.99 for the 1q44 region and substantially narrowed the linkage peak to approximately 7 Mb. Ordered subset analyses (OSA) identified significant LOD score increases for 2q35 and 18p11 when ranking families by HLA-DR status and identified a significant LOD score increase in region 2q35 when ranking families by linkage to chromosome 1q44. 1q44 is particularly interesting because of linkage evidence for this region in studies of both rheumatoid arthritis and systemic lupus erythematosus. SN - 1466-4879 UR - https://www.unboundmedicine.com/medline/citation/16341055/Examination_of_seven_candidate_regions_for_multiple_sclerosis:_strong_evidence_of_linkage_to_chromosome_1q44_ L2 - http://dx.doi.org/10.1038/sj.gene.6364275 DB - PRIME DP - Unbound Medicine ER -