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Repeated administration of lead decreases brain 5-HT metabolism and produces memory deficits in rats.
Cell Mol Biol Lett 2005; 10(4):669-76CM

Abstract

Long-term exposure to low levels of lead (Pb2+) has been shown to produce learning and memory deficits in rodents and humans. These deficits are thought to be associated with altered brain monoamine neurotransmission. Increased brain 5-HT (5-hydroxytryptamine; serotonin) activity is thought to be a prerequisite for maintaining control over the cognitive information process, and is said to have a role in learning and memory. This study was designed to investigate the effects of Pb2+ administration on brain 5-HT metabolism and memory function in rats. Rats were injected daily for three weeks with Pb2+-acetate at a dose of 100 mg/kg body weight. The assessment of memory was done using the Radial arm maze (RAM) and Passive avoidance tests. The results showed spatial working memory (SWM) deficits as well as decreased brain 5-HT metabolism. Increased serotonin activity is considered to be an indication of improved cognitive performance. The results are discussed in the context of lead-induced decreases in 5-HT metabolism playing a role in the impairment of memory.

Authors+Show Affiliations

Department of Biochemistry, Neurochemistry and Biochemical Neuropharmacology Research Unit, University of Karachi, Pakistan. aapa1@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16341275

Citation

Haider, Saida, et al. "Repeated Administration of Lead Decreases Brain 5-HT Metabolism and Produces Memory Deficits in Rats." Cellular & Molecular Biology Letters, vol. 10, no. 4, 2005, pp. 669-76.
Haider S, Shameem S, Ahmed SP, et al. Repeated administration of lead decreases brain 5-HT metabolism and produces memory deficits in rats. Cell Mol Biol Lett. 2005;10(4):669-76.
Haider, S., Shameem, S., Ahmed, S. P., Perveen, T., & Haleem, D. J. (2005). Repeated administration of lead decreases brain 5-HT metabolism and produces memory deficits in rats. Cellular & Molecular Biology Letters, 10(4), pp. 669-76.
Haider S, et al. Repeated Administration of Lead Decreases Brain 5-HT Metabolism and Produces Memory Deficits in Rats. Cell Mol Biol Lett. 2005;10(4):669-76. PubMed PMID: 16341275.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Repeated administration of lead decreases brain 5-HT metabolism and produces memory deficits in rats. AU - Haider,Saida, AU - Shameem,Saima, AU - Ahmed,Shahida P, AU - Perveen,Tahira, AU - Haleem,Darakhshan J, PY - 2005/12/13/pubmed PY - 2006/6/29/medline PY - 2005/12/13/entrez SP - 669 EP - 76 JF - Cellular & molecular biology letters JO - Cell. Mol. Biol. Lett. VL - 10 IS - 4 N2 - Long-term exposure to low levels of lead (Pb2+) has been shown to produce learning and memory deficits in rodents and humans. These deficits are thought to be associated with altered brain monoamine neurotransmission. Increased brain 5-HT (5-hydroxytryptamine; serotonin) activity is thought to be a prerequisite for maintaining control over the cognitive information process, and is said to have a role in learning and memory. This study was designed to investigate the effects of Pb2+ administration on brain 5-HT metabolism and memory function in rats. Rats were injected daily for three weeks with Pb2+-acetate at a dose of 100 mg/kg body weight. The assessment of memory was done using the Radial arm maze (RAM) and Passive avoidance tests. The results showed spatial working memory (SWM) deficits as well as decreased brain 5-HT metabolism. Increased serotonin activity is considered to be an indication of improved cognitive performance. The results are discussed in the context of lead-induced decreases in 5-HT metabolism playing a role in the impairment of memory. SN - 1425-8153 UR - https://www.unboundmedicine.com/medline/citation/16341275/Repeated_administration_of_lead_decreases_brain_5_HT_metabolism_and_produces_memory_deficits_in_rats_ L2 - http://www.cmbl.org.pl/pdf/Vol10_p669.pdf DB - PRIME DP - Unbound Medicine ER -