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Idiopathic juxtafoveal retinal telangiectasis: new findings by ultrahigh-resolution optical coherence tomography.
Ophthalmology 2006; 113(1):48-57O

Abstract

OBJECTIVE

To investigate the capabilities of ultrahigh-resolution optical coherence tomography (UHR OCT); to compare with the commercially available OCT standard-resolution system, StratusOCT, for imaging of idiopathic juxtafoveal retinal telangiectasis (IJT); and to demonstrate that UHR OCT provides additional information on disease morphology, pathogenesis, and management.

DESIGN

Retrospective, observational, interventional case series.

PARTICIPANTS

Nineteen eyes of 10 patients diagnosed with IJT in at least one eye.

METHOD

All patients were imaged with UHR OCT and StratusOCT at the same visit. A subset of patients was also imaged before and after treatment of IJT.

MAIN OUTCOME MEASURES

Ultrahigh- and standard-resolution cross-sectional tomograms of IJT pathology.

RESULTS

Using both standard- and ultrahigh-resolution OCT, we identified the following features of IJT: (1) a lack of correlation between retinal thickening on OCT and leakage on fluorescein angiography, (2) loss and disruption of the photoreceptor layer, (3) cystlike structures in the foveola and within internal retinal layers such as the inner nuclear or ganglion cell layers, (4) a unique internal limiting membrane draping across the foveola related to an underlying loss of tissue, (5) intraretinal neovascularization near the fovea, and (6) central intraretinal deposits and plaques. In 63% of cases, the presence of abnormal vessels and a discontinuity of the photoreceptor layer correlated with visual acuity.

CONCLUSIONS

Ultrahigh-resolution OCT improves visualization of the retinal pathology associated with IJT and allows identification of new features associated with it. Some of these features, such as discontinuity of the photoreceptor layer, are revealed only by UHR OCT.

Authors+Show Affiliations

New England Eye Center, Tufts-New England Medical Center, Tufts University, Boston, Massachusetts 02111, USA. jduker@tufts-nemc.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16343625

Citation

Paunescu, Lelia A., et al. "Idiopathic Juxtafoveal Retinal Telangiectasis: New Findings By Ultrahigh-resolution Optical Coherence Tomography." Ophthalmology, vol. 113, no. 1, 2006, pp. 48-57.
Paunescu LA, Ko TH, Duker JS, et al. Idiopathic juxtafoveal retinal telangiectasis: new findings by ultrahigh-resolution optical coherence tomography. Ophthalmology. 2006;113(1):48-57.
Paunescu, L. A., Ko, T. H., Duker, J. S., Chan, A., Drexler, W., Schuman, J. S., & Fujimoto, J. G. (2006). Idiopathic juxtafoveal retinal telangiectasis: new findings by ultrahigh-resolution optical coherence tomography. Ophthalmology, 113(1), pp. 48-57.
Paunescu LA, et al. Idiopathic Juxtafoveal Retinal Telangiectasis: New Findings By Ultrahigh-resolution Optical Coherence Tomography. Ophthalmology. 2006;113(1):48-57. PubMed PMID: 16343625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Idiopathic juxtafoveal retinal telangiectasis: new findings by ultrahigh-resolution optical coherence tomography. AU - Paunescu,Lelia A, AU - Ko,Tony H, AU - Duker,Jay S, AU - Chan,Annie, AU - Drexler,Wolfgang, AU - Schuman,Joel S, AU - Fujimoto,James G, Y1 - 2005/12/15/ PY - 2005/04/26/received PY - 2005/07/17/revised PY - 2005/08/19/accepted PY - 2005/12/14/pubmed PY - 2006/1/13/medline PY - 2005/12/14/entrez SP - 48 EP - 57 JF - Ophthalmology JO - Ophthalmology VL - 113 IS - 1 N2 - OBJECTIVE: To investigate the capabilities of ultrahigh-resolution optical coherence tomography (UHR OCT); to compare with the commercially available OCT standard-resolution system, StratusOCT, for imaging of idiopathic juxtafoveal retinal telangiectasis (IJT); and to demonstrate that UHR OCT provides additional information on disease morphology, pathogenesis, and management. DESIGN: Retrospective, observational, interventional case series. PARTICIPANTS: Nineteen eyes of 10 patients diagnosed with IJT in at least one eye. METHOD: All patients were imaged with UHR OCT and StratusOCT at the same visit. A subset of patients was also imaged before and after treatment of IJT. MAIN OUTCOME MEASURES: Ultrahigh- and standard-resolution cross-sectional tomograms of IJT pathology. RESULTS: Using both standard- and ultrahigh-resolution OCT, we identified the following features of IJT: (1) a lack of correlation between retinal thickening on OCT and leakage on fluorescein angiography, (2) loss and disruption of the photoreceptor layer, (3) cystlike structures in the foveola and within internal retinal layers such as the inner nuclear or ganglion cell layers, (4) a unique internal limiting membrane draping across the foveola related to an underlying loss of tissue, (5) intraretinal neovascularization near the fovea, and (6) central intraretinal deposits and plaques. In 63% of cases, the presence of abnormal vessels and a discontinuity of the photoreceptor layer correlated with visual acuity. CONCLUSIONS: Ultrahigh-resolution OCT improves visualization of the retinal pathology associated with IJT and allows identification of new features associated with it. Some of these features, such as discontinuity of the photoreceptor layer, are revealed only by UHR OCT. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/16343625/Idiopathic_juxtafoveal_retinal_telangiectasis:_new_findings_by_ultrahigh_resolution_optical_coherence_tomography_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(05)01173-5 DB - PRIME DP - Unbound Medicine ER -