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Venous thromboembolism after spinal cord injury: incidence, time course, and associated risk factors in 16,240 adults and children.
Arch Phys Med Rehabil 2005; 86(12):2240-7AP

Abstract

OBJECTIVE

To analyze the incidence of venous thromboembolism (VTE) after spinal cord injury (SCI).

DESIGN

Retrospective cohort analysis of all SCI cases (16,240) in California from 1991 through 2001.

SETTING

All public hospitals in California.

PARTICIPANTS

Subjects (cases) coded as having complete or incomplete SCI.

INTERVENTIONS

Not applicable.

MAIN OUTCOME MEASURE

Diagnosis of VTE or death within 91 days of the day of hospital admission.

RESULTS

For all cases, the 91-day cumulative incidence of VTE was 5.4%. In a multivariate model, significant predictors of VTE included male sex (odds ratio [OR]=1.4; 95% confidence interval [CI], 1.2-1.7), African-American race (OR=1.6; 95% CI, 1.3-1.9), complete paraplegia versus tetraplegia (OR=1.8; 95% CI, 1.4-2.3), and presence of 3 or more comorbid conditions versus none (OR=1.6; 95% CI, 1.3-2.1). Age less than 14 years was predictive of not developing VTE (OR=0.2; 95% CI, 0.1-0.7). The incidence of VTE did not change significantly over the 11-year time period (P=.07), and VTE was not a significant predictor of death in the first 91 days after hospitalization.

CONCLUSIONS

The incidence of VTE in SCI patients in California did not change between 1991 and 2001. We identified specific risk factors for VTE. Further studies are needed to determine if prompt initiation of medical prophylaxis in high risk subjects reduces the incidence of symptomatic VTE.

Authors+Show Affiliations

Department of Physical Medicine and Rehabilitation, Center for Health Services Research in Primary Care, University of California, Davis, CA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16344018

Citation

Jones, Tracey, et al. "Venous Thromboembolism After Spinal Cord Injury: Incidence, Time Course, and Associated Risk Factors in 16,240 Adults and Children." Archives of Physical Medicine and Rehabilitation, vol. 86, no. 12, 2005, pp. 2240-7.
Jones T, Ugalde V, Franks P, et al. Venous thromboembolism after spinal cord injury: incidence, time course, and associated risk factors in 16,240 adults and children. Arch Phys Med Rehabil. 2005;86(12):2240-7.
Jones, T., Ugalde, V., Franks, P., Zhou, H., & White, R. H. (2005). Venous thromboembolism after spinal cord injury: incidence, time course, and associated risk factors in 16,240 adults and children. Archives of Physical Medicine and Rehabilitation, 86(12), pp. 2240-7.
Jones T, et al. Venous Thromboembolism After Spinal Cord Injury: Incidence, Time Course, and Associated Risk Factors in 16,240 Adults and Children. Arch Phys Med Rehabil. 2005;86(12):2240-7. PubMed PMID: 16344018.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Venous thromboembolism after spinal cord injury: incidence, time course, and associated risk factors in 16,240 adults and children. AU - Jones,Tracey, AU - Ugalde,Viviane, AU - Franks,Peter, AU - Zhou,Hong, AU - White,Richard H, PY - 2005/02/28/received PY - 2005/06/03/revised PY - 2005/07/05/accepted PY - 2005/12/14/pubmed PY - 2006/2/9/medline PY - 2005/12/14/entrez SP - 2240 EP - 7 JF - Archives of physical medicine and rehabilitation JO - Arch Phys Med Rehabil VL - 86 IS - 12 N2 - OBJECTIVE: To analyze the incidence of venous thromboembolism (VTE) after spinal cord injury (SCI). DESIGN: Retrospective cohort analysis of all SCI cases (16,240) in California from 1991 through 2001. SETTING: All public hospitals in California. PARTICIPANTS: Subjects (cases) coded as having complete or incomplete SCI. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURE: Diagnosis of VTE or death within 91 days of the day of hospital admission. RESULTS: For all cases, the 91-day cumulative incidence of VTE was 5.4%. In a multivariate model, significant predictors of VTE included male sex (odds ratio [OR]=1.4; 95% confidence interval [CI], 1.2-1.7), African-American race (OR=1.6; 95% CI, 1.3-1.9), complete paraplegia versus tetraplegia (OR=1.8; 95% CI, 1.4-2.3), and presence of 3 or more comorbid conditions versus none (OR=1.6; 95% CI, 1.3-2.1). Age less than 14 years was predictive of not developing VTE (OR=0.2; 95% CI, 0.1-0.7). The incidence of VTE did not change significantly over the 11-year time period (P=.07), and VTE was not a significant predictor of death in the first 91 days after hospitalization. CONCLUSIONS: The incidence of VTE in SCI patients in California did not change between 1991 and 2001. We identified specific risk factors for VTE. Further studies are needed to determine if prompt initiation of medical prophylaxis in high risk subjects reduces the incidence of symptomatic VTE. SN - 0003-9993 UR - https://www.unboundmedicine.com/medline/citation/16344018/Venous_thromboembolism_after_spinal_cord_injury:_incidence_time_course_and_associated_risk_factors_in_16240_adults_and_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-9993(05)00915-9 DB - PRIME DP - Unbound Medicine ER -