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Coffee and tea consumption are associated with a lower incidence of chronic liver disease in the United States.
Gastroenterology 2005; 129(6):1928-36G

Abstract

BACKGROUND & AIMS

Coffee drinking has been suggested to protect against liver injury, but it is uncertain whether this is of clinical significance. We examined the relationship of coffee and tea consumption with the incidence of hospitalization or death from chronic liver disease (CLD).

METHODS

Participants in the population-based, first National Health and Nutrition Examination Survey, 1971-1975, were asked about coffee and tea consumption, which was categorized as <1 cup (mean, 0.2 cups), 1 to 2 cups, and >2 cups per day (mean, 4.0 cups). A second analysis included persons who, in 1982-1984, were asked more detailed questions on coffee and tea drinking. Participants were followed through 1992-1993 for a hospital or death certificate diagnosis of CLD or cirrhosis (ICD-9-CM 571). Hazard rate ratios for CLD according to coffee and tea intake were calculated using Cox proportional hazards analysis.

RESULTS

Among 9849 persons followed for a median of 19.0 years (range, 0.02-22.1), the cumulative incidence of CLD was 1.4%. In multivariate analysis, participants who drank >2 cups per day had less than half the rate of CLD as those who drank <1 cup per day (hazard ratio, 0.43, 95% confidence interval: 0.24-0.78). Protection by coffee and tea was limited to persons at higher risk for liver diseases from heavier alcohol intake, overweight, diabetes, or high iron saturation. Among 9650 participants who provided detailed drink information in 1982-1984, intake of regular ground coffee and of caffeine was associated with lower incidence of CLD.

CONCLUSIONS

Coffee and tea drinking decreases the risk of clinically significant CLD.

Authors+Show Affiliations

Social and Scientific Systems, Inc, Silver Spring, Maryland 20910, USA. cruhl@s-3.comNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16344061

Citation

Ruhl, Constance E., and James E. Everhart. "Coffee and Tea Consumption Are Associated With a Lower Incidence of Chronic Liver Disease in the United States." Gastroenterology, vol. 129, no. 6, 2005, pp. 1928-36.
Ruhl CE, Everhart JE. Coffee and tea consumption are associated with a lower incidence of chronic liver disease in the United States. Gastroenterology. 2005;129(6):1928-36.
Ruhl, C. E., & Everhart, J. E. (2005). Coffee and tea consumption are associated with a lower incidence of chronic liver disease in the United States. Gastroenterology, 129(6), pp. 1928-36.
Ruhl CE, Everhart JE. Coffee and Tea Consumption Are Associated With a Lower Incidence of Chronic Liver Disease in the United States. Gastroenterology. 2005;129(6):1928-36. PubMed PMID: 16344061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coffee and tea consumption are associated with a lower incidence of chronic liver disease in the United States. AU - Ruhl,Constance E, AU - Everhart,James E, PY - 2005/06/23/received PY - 2005/08/17/accepted PY - 2005/12/14/pubmed PY - 2006/2/4/medline PY - 2005/12/14/entrez SP - 1928 EP - 36 JF - Gastroenterology JO - Gastroenterology VL - 129 IS - 6 N2 - BACKGROUND & AIMS: Coffee drinking has been suggested to protect against liver injury, but it is uncertain whether this is of clinical significance. We examined the relationship of coffee and tea consumption with the incidence of hospitalization or death from chronic liver disease (CLD). METHODS: Participants in the population-based, first National Health and Nutrition Examination Survey, 1971-1975, were asked about coffee and tea consumption, which was categorized as <1 cup (mean, 0.2 cups), 1 to 2 cups, and >2 cups per day (mean, 4.0 cups). A second analysis included persons who, in 1982-1984, were asked more detailed questions on coffee and tea drinking. Participants were followed through 1992-1993 for a hospital or death certificate diagnosis of CLD or cirrhosis (ICD-9-CM 571). Hazard rate ratios for CLD according to coffee and tea intake were calculated using Cox proportional hazards analysis. RESULTS: Among 9849 persons followed for a median of 19.0 years (range, 0.02-22.1), the cumulative incidence of CLD was 1.4%. In multivariate analysis, participants who drank >2 cups per day had less than half the rate of CLD as those who drank <1 cup per day (hazard ratio, 0.43, 95% confidence interval: 0.24-0.78). Protection by coffee and tea was limited to persons at higher risk for liver diseases from heavier alcohol intake, overweight, diabetes, or high iron saturation. Among 9650 participants who provided detailed drink information in 1982-1984, intake of regular ground coffee and of caffeine was associated with lower incidence of CLD. CONCLUSIONS: Coffee and tea drinking decreases the risk of clinically significant CLD. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/16344061/Coffee_and_tea_consumption_are_associated_with_a_lower_incidence_of_chronic_liver_disease_in_the_United_States_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5085(05)01774-9 DB - PRIME DP - Unbound Medicine ER -