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Effects of testosterone on cognition and mood in male patients with mild Alzheimer disease and healthy elderly men.
Arch Neurol. 2006 Feb; 63(2):177-85.AN

Abstract

CONTEXT

There is a compelling need for therapies that prevent, defer the onset, slow the progression, or improve the symptoms of Alzheimer disease (AD).

OBJECTIVE

To evaluate the effects of testosterone therapy on cognition, neuropsychiatric symptoms, and quality of life in male patients with mild AD and healthy elderly men.

DESIGN

Twenty-four-week, randomized, double-blind, placebo-controlled, parallel-group study.

SETTING

Memory disorders clinics as well as general neurology and medicine clinics from University of California medical centers at Los Angeles, San Francisco, and Irvine.

PATIENTS OR OTHER PARTICIPANTS

Sixteen male patients with AD and 22 healthy male control subjects. Healthy elderly control men were recruited from the community through advertisements as well as through the university-based clinics.

INTERVENTION

Testosterone and placebo, in the form of hydroalcoholic gel (75 mg), were applied daily to the skin of the participants.

MAIN OUTCOME MEASURES

Instruments assessing cognitive functioning (Alzheimer's Disease Assessment Scale-Cognitive Subscale, California Verbal Learning Test, Block Design Subtest, Judgment of Line Orientation, Developmental Test of Visual-Motor Integration), neuropsychiatric symptoms (Neuropsychiatric Inventory), global functioning (Clinician's Interview-Based Impression of Change), and quality of life (Quality of Life-Alzheimer Disease Scale).

RESULTS

For the patients with AD, the testosterone-treated group had significantly greater improvements in the scores on the caregiver version of the quality-of-life scale (P = .01). No significant treatment group differences were detected in the cognitive scores at end of study, although numerically greater improvement or less decline on measures of visuospatial functions was demonstrated with testosterone treatment compared with placebo. In the healthy control group, a nonsignificant trend toward greater improvement in self-rated quality of life was observed in the testosterone-treated group (P = .09) compared with placebo treatment. No difference between the treatment groups was detected in the remaining outcome measures. Testosterone treatment was well tolerated with few adverse effects relative to placebo.

CONCLUSIONS

Results suggest that testosterone replacement therapy improved overall quality of life in patients with AD. Testosterone had minimal effects on cognition.

Authors+Show Affiliations

Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, USA. plu@mednet.ucla.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16344336

Citation

Lu, Po H., et al. "Effects of Testosterone On Cognition and Mood in Male Patients With Mild Alzheimer Disease and Healthy Elderly Men." Archives of Neurology, vol. 63, no. 2, 2006, pp. 177-85.
Lu PH, Masterman DA, Mulnard R, et al. Effects of testosterone on cognition and mood in male patients with mild Alzheimer disease and healthy elderly men. Arch Neurol. 2006;63(2):177-85.
Lu, P. H., Masterman, D. A., Mulnard, R., Cotman, C., Miller, B., Yaffe, K., Reback, E., Porter, V., Swerdloff, R., & Cummings, J. L. (2006). Effects of testosterone on cognition and mood in male patients with mild Alzheimer disease and healthy elderly men. Archives of Neurology, 63(2), 177-85.
Lu PH, et al. Effects of Testosterone On Cognition and Mood in Male Patients With Mild Alzheimer Disease and Healthy Elderly Men. Arch Neurol. 2006;63(2):177-85. PubMed PMID: 16344336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of testosterone on cognition and mood in male patients with mild Alzheimer disease and healthy elderly men. AU - Lu,Po H, AU - Masterman,Donna A, AU - Mulnard,Ruth, AU - Cotman,Carl, AU - Miller,Bruce, AU - Yaffe,Kristine, AU - Reback,Erin, AU - Porter,Verna, AU - Swerdloff,Ronald, AU - Cummings,Jeffrey L, Y1 - 2005/12/12/ PY - 2005/12/14/pubmed PY - 2006/3/1/medline PY - 2005/12/14/entrez SP - 177 EP - 85 JF - Archives of neurology JO - Arch Neurol VL - 63 IS - 2 N2 - CONTEXT: There is a compelling need for therapies that prevent, defer the onset, slow the progression, or improve the symptoms of Alzheimer disease (AD). OBJECTIVE: To evaluate the effects of testosterone therapy on cognition, neuropsychiatric symptoms, and quality of life in male patients with mild AD and healthy elderly men. DESIGN: Twenty-four-week, randomized, double-blind, placebo-controlled, parallel-group study. SETTING: Memory disorders clinics as well as general neurology and medicine clinics from University of California medical centers at Los Angeles, San Francisco, and Irvine. PATIENTS OR OTHER PARTICIPANTS: Sixteen male patients with AD and 22 healthy male control subjects. Healthy elderly control men were recruited from the community through advertisements as well as through the university-based clinics. INTERVENTION: Testosterone and placebo, in the form of hydroalcoholic gel (75 mg), were applied daily to the skin of the participants. MAIN OUTCOME MEASURES: Instruments assessing cognitive functioning (Alzheimer's Disease Assessment Scale-Cognitive Subscale, California Verbal Learning Test, Block Design Subtest, Judgment of Line Orientation, Developmental Test of Visual-Motor Integration), neuropsychiatric symptoms (Neuropsychiatric Inventory), global functioning (Clinician's Interview-Based Impression of Change), and quality of life (Quality of Life-Alzheimer Disease Scale). RESULTS: For the patients with AD, the testosterone-treated group had significantly greater improvements in the scores on the caregiver version of the quality-of-life scale (P = .01). No significant treatment group differences were detected in the cognitive scores at end of study, although numerically greater improvement or less decline on measures of visuospatial functions was demonstrated with testosterone treatment compared with placebo. In the healthy control group, a nonsignificant trend toward greater improvement in self-rated quality of life was observed in the testosterone-treated group (P = .09) compared with placebo treatment. No difference between the treatment groups was detected in the remaining outcome measures. Testosterone treatment was well tolerated with few adverse effects relative to placebo. CONCLUSIONS: Results suggest that testosterone replacement therapy improved overall quality of life in patients with AD. Testosterone had minimal effects on cognition. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/16344336/Effects_of_testosterone_on_cognition_and_mood_in_male_patients_with_mild_Alzheimer_disease_and_healthy_elderly_men_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneur.63.2.nct50002 DB - PRIME DP - Unbound Medicine ER -