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Efficacy of azathioprine on multiple sclerosis new brain lesions evaluated using magnetic resonance imaging.
Arch Neurol 2005; 62(12):1843-7AN

Abstract

BACKGROUND

Azathioprine is an immunosuppressive agent that reduces relapse rates in patients with multiple sclerosis (MS), but its efficacy in suppressing new brain lesions has never been evaluated.

OBJECTIVE

To evaluate the efficacy of azathioprine therapy on new brain lesion suppression in MS.

DESIGN

Open-label treatment vs baseline study.

SETTING

Outpatient MS clinical center at a university hospital.

PATIENTS

Fourteen patients with relapsing-remitting MS of short duration and at least 3 gadolinium-enhancing (Gd+) brain lesions observed within 6 months before treatment.

INTERVENTION

Azathioprine, up to 3 mg/kg daily, individually adjusted according to blood lymphocyte number and the occurrence of adverse events.

MAIN OUTCOME MEASURES

Brain Gd+ lesions evaluated by monthly magnetic resonance imaging for 6 months before and 6 months during treatment and new T2 lesions evaluated during the same periods and after an additional 6 months.

RESULTS

The treatment reduced to 0 the median Gd+ lesion number and volume per magnetic resonance image (P<.001 for both), resulting in a Gd+ lesion number reduction of 50% or more in 12 of 14 patients (P<.01). An equivalent reduction in the new T2 lesion number was observed (P<.02); this activity also persisted during the additional treatment period evaluated using this outcome measure (P<.01). The median azathioprine dose administered (2.6-2.8 mg/kg daily) reduced the mean blood lymphocyte count to 57% of the baseline value. Adverse events were transient or reversible with dose adjustment.

CONCLUSIONS

This study indicates for the first time that azathioprine, administered at lymphocyte-suppressing doses, is effective in reducing MS new brain inflammatory lesions and is well tolerated.

Authors+Show Affiliations

Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy. massacesi@unifi.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16344342

Citation

Massacesi, Luca, et al. "Efficacy of Azathioprine On Multiple Sclerosis New Brain Lesions Evaluated Using Magnetic Resonance Imaging." Archives of Neurology, vol. 62, no. 12, 2005, pp. 1843-7.
Massacesi L, Parigi A, Barilaro A, et al. Efficacy of azathioprine on multiple sclerosis new brain lesions evaluated using magnetic resonance imaging. Arch Neurol. 2005;62(12):1843-7.
Massacesi, L., Parigi, A., Barilaro, A., Repice, A. M., Pellicanò, G., Konze, A., ... Amaducci, L. (2005). Efficacy of azathioprine on multiple sclerosis new brain lesions evaluated using magnetic resonance imaging. Archives of Neurology, 62(12), pp. 1843-7.
Massacesi L, et al. Efficacy of Azathioprine On Multiple Sclerosis New Brain Lesions Evaluated Using Magnetic Resonance Imaging. Arch Neurol. 2005;62(12):1843-7. PubMed PMID: 16344342.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of azathioprine on multiple sclerosis new brain lesions evaluated using magnetic resonance imaging. AU - Massacesi,Luca, AU - Parigi,Alessandro, AU - Barilaro,Alessandro, AU - Repice,Anna Maria, AU - Pellicanò,Gianni, AU - Konze,Angela, AU - Siracusa,Gianfranco, AU - Taiuti,Rosanna, AU - Amaducci,Luigi, PY - 2005/12/14/pubmed PY - 2006/1/21/medline PY - 2005/12/14/entrez SP - 1843 EP - 7 JF - Archives of neurology JO - Arch. Neurol. VL - 62 IS - 12 N2 - BACKGROUND: Azathioprine is an immunosuppressive agent that reduces relapse rates in patients with multiple sclerosis (MS), but its efficacy in suppressing new brain lesions has never been evaluated. OBJECTIVE: To evaluate the efficacy of azathioprine therapy on new brain lesion suppression in MS. DESIGN: Open-label treatment vs baseline study. SETTING: Outpatient MS clinical center at a university hospital. PATIENTS: Fourteen patients with relapsing-remitting MS of short duration and at least 3 gadolinium-enhancing (Gd+) brain lesions observed within 6 months before treatment. INTERVENTION: Azathioprine, up to 3 mg/kg daily, individually adjusted according to blood lymphocyte number and the occurrence of adverse events. MAIN OUTCOME MEASURES: Brain Gd+ lesions evaluated by monthly magnetic resonance imaging for 6 months before and 6 months during treatment and new T2 lesions evaluated during the same periods and after an additional 6 months. RESULTS: The treatment reduced to 0 the median Gd+ lesion number and volume per magnetic resonance image (P<.001 for both), resulting in a Gd+ lesion number reduction of 50% or more in 12 of 14 patients (P<.01). An equivalent reduction in the new T2 lesion number was observed (P<.02); this activity also persisted during the additional treatment period evaluated using this outcome measure (P<.01). The median azathioprine dose administered (2.6-2.8 mg/kg daily) reduced the mean blood lymphocyte count to 57% of the baseline value. Adverse events were transient or reversible with dose adjustment. CONCLUSIONS: This study indicates for the first time that azathioprine, administered at lymphocyte-suppressing doses, is effective in reducing MS new brain inflammatory lesions and is well tolerated. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/16344342/Efficacy_of_azathioprine_on_multiple_sclerosis_new_brain_lesions_evaluated_using_magnetic_resonance_imaging_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneur.62.12.1843 DB - PRIME DP - Unbound Medicine ER -