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Evaluation of a clinical screening tool for HIV-associated sensory neuropathies.
Neurology. 2005 Dec 13; 65(11):1778-81.Neur

Abstract

OBJECTIVE

To evaluate the performance characteristics of a brief clinical neuropathy screening tool for use in sensory neuropathies complicating HIV infection.

METHODS

The authors assessed 80 patients using the Brief Peripheral Neuropathy Screen (BPNS). Patients were defined as having neuropathy if they had both symptoms and signs consistent with this diagnosis. All subjects underwent sensory threshold testing and lower limb epidermal nerve fiber quantification using punch skin biopsy as objective measures.

RESULTS

Individuals defined as having neuropathy using the BPNS (n = 37) performed less well on sensory threshold testing than other HIV-infected individuals (p < 0.0001 for warming, cooling, and vibration) and also had lower distal calf epidermal nerve fiber densities (p < 0.0001). Individuals who had symptoms but no neuropathic signs (n = 13) did not perform differently on any objective testing compared with neuropathy-free individuals, supporting the decision to require signs as well as symptoms as an operational criterion for the diagnosis of neuropathy. Of the symptoms listed in the screening tool, the presence of numbness had the greatest diagnostic efficiency for identifying those with neuropathy.

CONCLUSION

The Brief Neuropathy Screening Tool (and the chosen definition of neuropathy) accurately detects those HIV-infected individuals with the greatest degree of peripheral nerve dysfunction and pathology. This is a valid neuropathy screening tool for use in the context of HIV infection, and is simple enough to be applicable in resource-limited settings.

Authors+Show Affiliations

Burnet Institute, Melbourne, Australia. kate.cherry@med.monash.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16344522

Citation

Cherry, Catherine L., et al. "Evaluation of a Clinical Screening Tool for HIV-associated Sensory Neuropathies." Neurology, vol. 65, no. 11, 2005, pp. 1778-81.
Cherry CL, Wesselingh SL, Lal L, et al. Evaluation of a clinical screening tool for HIV-associated sensory neuropathies. Neurology. 2005;65(11):1778-81.
Cherry, C. L., Wesselingh, S. L., Lal, L., & McArthur, J. C. (2005). Evaluation of a clinical screening tool for HIV-associated sensory neuropathies. Neurology, 65(11), 1778-81.
Cherry CL, et al. Evaluation of a Clinical Screening Tool for HIV-associated Sensory Neuropathies. Neurology. 2005 Dec 13;65(11):1778-81. PubMed PMID: 16344522.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of a clinical screening tool for HIV-associated sensory neuropathies. AU - Cherry,Catherine L, AU - Wesselingh,Steven L, AU - Lal,Luxshimi, AU - McArthur,Justin C, PY - 2005/12/14/pubmed PY - 2006/3/24/medline PY - 2005/12/14/entrez SP - 1778 EP - 81 JF - Neurology JO - Neurology VL - 65 IS - 11 N2 - OBJECTIVE: To evaluate the performance characteristics of a brief clinical neuropathy screening tool for use in sensory neuropathies complicating HIV infection. METHODS: The authors assessed 80 patients using the Brief Peripheral Neuropathy Screen (BPNS). Patients were defined as having neuropathy if they had both symptoms and signs consistent with this diagnosis. All subjects underwent sensory threshold testing and lower limb epidermal nerve fiber quantification using punch skin biopsy as objective measures. RESULTS: Individuals defined as having neuropathy using the BPNS (n = 37) performed less well on sensory threshold testing than other HIV-infected individuals (p < 0.0001 for warming, cooling, and vibration) and also had lower distal calf epidermal nerve fiber densities (p < 0.0001). Individuals who had symptoms but no neuropathic signs (n = 13) did not perform differently on any objective testing compared with neuropathy-free individuals, supporting the decision to require signs as well as symptoms as an operational criterion for the diagnosis of neuropathy. Of the symptoms listed in the screening tool, the presence of numbness had the greatest diagnostic efficiency for identifying those with neuropathy. CONCLUSION: The Brief Neuropathy Screening Tool (and the chosen definition of neuropathy) accurately detects those HIV-infected individuals with the greatest degree of peripheral nerve dysfunction and pathology. This is a valid neuropathy screening tool for use in the context of HIV infection, and is simple enough to be applicable in resource-limited settings. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/16344522/Evaluation_of_a_clinical_screening_tool_for_HIV_associated_sensory_neuropathies_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&amp;pmid=16344522 DB - PRIME DP - Unbound Medicine ER -