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Crossvalidation of anthropometry against magnetic resonance imaging for the assessment of visceral and subcutaneous adipose tissue in children.
Int J Obes (Lond). 2006 Jan; 30(1):23-30.IJ

Abstract

BACKGROUND

The study of the relationship between anthropometry and visceral adipose tissue (VAT) is of great interest because VAT is associated with many risk factors for noncommunicable diseases and anthropometry is easy to perform in clinical practice. The studies hitherto available for children have, however, been performed on small sample sizes.

DESIGN

Pooling of the data of studies published from 1992 to 2004 as indexed on Medline.

AIMS

To assess the relationship between anthropometry and VAT and subcutaneous adipose tissue (SAT) as measured by magnetic resonance imaging (MRI) in children and to analyze the effect of age, gender, pubertal status and ethnicity.

SUBJECTS AND METHODS

Eligible subjects were 7-16 year-old, with availability of VAT and SAT, gender, ethnicity, body mass index (BMI) and waist circumference (WC). A total of 497 subjects were collected from seven different investigators and 407 of them (178 Caucasians and 229 Hispanics) were analyzed.

RESULTS

Despite ethnic differences in MRI data, BMI, WC and age, no difference in VAT was found between Caucasians and Hispanics after correction for SAT and BMI. Univariate regression analysis identified WC as the best single predictor of VAT (64.8% of variance) and BMI of SAT (88.9% of variance). The contribution of ethnicity and gender to the unexplained variance of the VAT-WC relationship was low (< or =3%) but significant (P < or =0.002). The different laboratories explained a low (< or =4.8%) but significant (P < 0.0001) portion of the unexplained variance of the VAT-WC and SAT-BMI relationships. Prediction equations for VAT (VAT (cm(2)) = 1.1 x WC (cm)-52.9) and SAT (SAT (cm(2)) = 23.2 x BMI (kg/m(2))-329) were developed on a randomly chosen half of the population and crossvalidated in the remaining half. The pure error of the estimate was 13 cm(2) for VAT and 57 cm(2) for SAT.

CONCLUSIONS

WC can be considered a good predictor of VAT as well as BMI of SAT. The importance of ethnicity and gender on VAT estimation is not negligible.

Authors+Show Affiliations

Department of Pediatrics, Scientific Institute H San Raffaele, Milan, Italy. paolo.brambilla3@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review
Validation Study

Language

eng

PubMed ID

16344845

Citation

Brambilla, P, et al. "Crossvalidation of Anthropometry Against Magnetic Resonance Imaging for the Assessment of Visceral and Subcutaneous Adipose Tissue in Children." International Journal of Obesity (2005), vol. 30, no. 1, 2006, pp. 23-30.
Brambilla P, Bedogni G, Moreno LA, et al. Crossvalidation of anthropometry against magnetic resonance imaging for the assessment of visceral and subcutaneous adipose tissue in children. Int J Obes (Lond). 2006;30(1):23-30.
Brambilla, P., Bedogni, G., Moreno, L. A., Goran, M. I., Gutin, B., Fox, K. R., Peters, D. M., Barbeau, P., De Simone, M., & Pietrobelli, A. (2006). Crossvalidation of anthropometry against magnetic resonance imaging for the assessment of visceral and subcutaneous adipose tissue in children. International Journal of Obesity (2005), 30(1), 23-30.
Brambilla P, et al. Crossvalidation of Anthropometry Against Magnetic Resonance Imaging for the Assessment of Visceral and Subcutaneous Adipose Tissue in Children. Int J Obes (Lond). 2006;30(1):23-30. PubMed PMID: 16344845.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Crossvalidation of anthropometry against magnetic resonance imaging for the assessment of visceral and subcutaneous adipose tissue in children. AU - Brambilla,P, AU - Bedogni,G, AU - Moreno,L A, AU - Goran,M I, AU - Gutin,B, AU - Fox,K R, AU - Peters,D M, AU - Barbeau,P, AU - De Simone,M, AU - Pietrobelli,A, PY - 2005/12/14/pubmed PY - 2006/7/21/medline PY - 2005/12/14/entrez SP - 23 EP - 30 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 30 IS - 1 N2 - BACKGROUND: The study of the relationship between anthropometry and visceral adipose tissue (VAT) is of great interest because VAT is associated with many risk factors for noncommunicable diseases and anthropometry is easy to perform in clinical practice. The studies hitherto available for children have, however, been performed on small sample sizes. DESIGN: Pooling of the data of studies published from 1992 to 2004 as indexed on Medline. AIMS: To assess the relationship between anthropometry and VAT and subcutaneous adipose tissue (SAT) as measured by magnetic resonance imaging (MRI) in children and to analyze the effect of age, gender, pubertal status and ethnicity. SUBJECTS AND METHODS: Eligible subjects were 7-16 year-old, with availability of VAT and SAT, gender, ethnicity, body mass index (BMI) and waist circumference (WC). A total of 497 subjects were collected from seven different investigators and 407 of them (178 Caucasians and 229 Hispanics) were analyzed. RESULTS: Despite ethnic differences in MRI data, BMI, WC and age, no difference in VAT was found between Caucasians and Hispanics after correction for SAT and BMI. Univariate regression analysis identified WC as the best single predictor of VAT (64.8% of variance) and BMI of SAT (88.9% of variance). The contribution of ethnicity and gender to the unexplained variance of the VAT-WC relationship was low (< or =3%) but significant (P < or =0.002). The different laboratories explained a low (< or =4.8%) but significant (P < 0.0001) portion of the unexplained variance of the VAT-WC and SAT-BMI relationships. Prediction equations for VAT (VAT (cm(2)) = 1.1 x WC (cm)-52.9) and SAT (SAT (cm(2)) = 23.2 x BMI (kg/m(2))-329) were developed on a randomly chosen half of the population and crossvalidated in the remaining half. The pure error of the estimate was 13 cm(2) for VAT and 57 cm(2) for SAT. CONCLUSIONS: WC can be considered a good predictor of VAT as well as BMI of SAT. The importance of ethnicity and gender on VAT estimation is not negligible. SN - 0307-0565 UR - https://www.unboundmedicine.com/medline/citation/16344845/Crossvalidation_of_anthropometry_against_magnetic_resonance_imaging_for_the_assessment_of_visceral_and_subcutaneous_adipose_tissue_in_children_ L2 - https://doi.org/10.1038/sj.ijo.0803163 DB - PRIME DP - Unbound Medicine ER -