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Role of carotid intima-media thickness in assessment of atherosclerosis: an autopsy study.
Indian Heart J. 2005 Jul-Aug; 57(4):319-23.IH

Abstract

BACKGROUND

The non-invasive technique of measuring carotid artery intima-media thickness has generated considerable interest as a marker of atherosclerosis, particularly in predicting clinical coronary events and coronary artery disease. In the present study, a postmortem comparative analysis of intima-media thickness of carotid artery with coronary artery atherosclerosis has been carried out. To date no such morphological tissue studies are available from our country.

METHODS AND RESULTS

Right and left common carotid arteries with their branches were removed at postmortem in 40 cases with history of diabetes, hypertension or both. Intima-media thickness was measured and compared with coronary artery atherosclerosis. There were 10 control postmortem cases without history of diabetes or hypertension. Common carotid artery and internal carotid artery intima-media thickness were found to be good predictors of coronary events. There was also significant correlation (by Pearson's correlation formula) between the carotid artery intima-media thickness and the percentage of block in the coronary arteries.

CONCLUSIONS

Internal carotid artery along with common carotid artery intima-media thickness measurement is a good predictor of coronary artery disease. However, carotid artery intima-media thickness has no bearing on the status of collateral circulation of the coronary arteries.

Authors+Show Affiliations

Department of Pathology, TN Medical College and BYL Nair Ch Hospital, Mumbai. kusumjash@hotmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16350677

Citation

Jashnani, Kusum D., et al. "Role of Carotid Intima-media Thickness in Assessment of Atherosclerosis: an Autopsy Study." Indian Heart Journal, vol. 57, no. 4, 2005, pp. 319-23.
Jashnani KD, Kulkarni RR, Deshpande JR. Role of carotid intima-media thickness in assessment of atherosclerosis: an autopsy study. Indian Heart J. 2005;57(4):319-23.
Jashnani, K. D., Kulkarni, R. R., & Deshpande, J. R. (2005). Role of carotid intima-media thickness in assessment of atherosclerosis: an autopsy study. Indian Heart Journal, 57(4), 319-23.
Jashnani KD, Kulkarni RR, Deshpande JR. Role of Carotid Intima-media Thickness in Assessment of Atherosclerosis: an Autopsy Study. Indian Heart J. 2005 Jul-Aug;57(4):319-23. PubMed PMID: 16350677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of carotid intima-media thickness in assessment of atherosclerosis: an autopsy study. AU - Jashnani,Kusum D, AU - Kulkarni,Rohit R, AU - Deshpande,Jaya R, PY - 2005/12/15/pubmed PY - 2006/1/4/medline PY - 2005/12/15/entrez SP - 319 EP - 23 JF - Indian heart journal JO - Indian Heart J VL - 57 IS - 4 N2 - BACKGROUND: The non-invasive technique of measuring carotid artery intima-media thickness has generated considerable interest as a marker of atherosclerosis, particularly in predicting clinical coronary events and coronary artery disease. In the present study, a postmortem comparative analysis of intima-media thickness of carotid artery with coronary artery atherosclerosis has been carried out. To date no such morphological tissue studies are available from our country. METHODS AND RESULTS: Right and left common carotid arteries with their branches were removed at postmortem in 40 cases with history of diabetes, hypertension or both. Intima-media thickness was measured and compared with coronary artery atherosclerosis. There were 10 control postmortem cases without history of diabetes or hypertension. Common carotid artery and internal carotid artery intima-media thickness were found to be good predictors of coronary events. There was also significant correlation (by Pearson's correlation formula) between the carotid artery intima-media thickness and the percentage of block in the coronary arteries. CONCLUSIONS: Internal carotid artery along with common carotid artery intima-media thickness measurement is a good predictor of coronary artery disease. However, carotid artery intima-media thickness has no bearing on the status of collateral circulation of the coronary arteries. SN - 0019-4832 UR - https://www.unboundmedicine.com/medline/citation/16350677/Role_of_carotid_intima_media_thickness_in_assessment_of_atherosclerosis:_an_autopsy_study_ L2 - https://medlineplus.gov/coronaryarterydisease.html DB - PRIME DP - Unbound Medicine ER -