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Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer.
Nano Lett. 2005 Dec; 5(12):2426-31.NL

Abstract

Photodynamic therapy (PDT) for exudative age-related macular degeneration (AMD) was evaluated using a supramolecular nanomedical device, that is, a novel dendritic photosensitizer (DP) encapsulated by a polymeric micelle formulation. The characteristic dendritic structure of the DP prevents aggregation of its core sensitizer, thereby inducing a highly effective photochemical reaction. With its highly selective accumulation on choroidal neovascularization (CNV) lesions, this treatment resulted in a remarkably efficacious CNV occlusion with minimal unfavorable phototoxicity.

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Authors+Show Affiliations

Ideta R
Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Tasaka F
No affiliation info available
Jang WD
No affiliation info available
Nishiyama N
No affiliation info available
Zhang GD
No affiliation info available
Harada A
No affiliation info available
Yanagi Y
No affiliation info available
Tamaki Y
No affiliation info available
Aida T
No affiliation info available
Kataoka K
No affiliation info available

MeSH

AnimalsDrug CarriersGlaucoma, NeovascularMacromolecular SubstancesMaleNanotechnologyPhotochemotherapyPhotosensitizing AgentsPorphyrinsRats

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16351191

Citation

Ideta, Ryuichi, et al. "Nanotechnology-based Photodynamic Therapy for Neovascular Disease Using a Supramolecular Nanocarrier Loaded With a Dendritic Photosensitizer." Nano Letters, vol. 5, no. 12, 2005, pp. 2426-31.
Ideta R, Tasaka F, Jang WD, et al. Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer. Nano Lett. 2005;5(12):2426-31.
Ideta, R., Tasaka, F., Jang, W. D., Nishiyama, N., Zhang, G. D., Harada, A., Yanagi, Y., Tamaki, Y., Aida, T., & Kataoka, K. (2005). Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer. Nano Letters, 5(12), 2426-31.
Ideta R, et al. Nanotechnology-based Photodynamic Therapy for Neovascular Disease Using a Supramolecular Nanocarrier Loaded With a Dendritic Photosensitizer. Nano Lett. 2005;5(12):2426-31. PubMed PMID: 16351191.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer. AU - Ideta,Ryuichi, AU - Tasaka,Fumitaka, AU - Jang,Woo-Dong, AU - Nishiyama,Nobuhiro, AU - Zhang,Guo-Dong, AU - Harada,Atsushi, AU - Yanagi,Yasuo, AU - Tamaki,Yasuhiro, AU - Aida,Takuzo, AU - Kataoka,Kazunori, PY - 2005/12/15/pubmed PY - 2006/1/24/medline PY - 2005/12/15/entrez SP - 2426 EP - 31 JF - Nano letters JO - Nano Lett VL - 5 IS - 12 N2 - Photodynamic therapy (PDT) for exudative age-related macular degeneration (AMD) was evaluated using a supramolecular nanomedical device, that is, a novel dendritic photosensitizer (DP) encapsulated by a polymeric micelle formulation. The characteristic dendritic structure of the DP prevents aggregation of its core sensitizer, thereby inducing a highly effective photochemical reaction. With its highly selective accumulation on choroidal neovascularization (CNV) lesions, this treatment resulted in a remarkably efficacious CNV occlusion with minimal unfavorable phototoxicity. SN - 1530-6984 UR - https://www.unboundmedicine.com/medline/citation/16351191/Nanotechnology_based_photodynamic_therapy_for_neovascular_disease_using_a_supramolecular_nanocarrier_loaded_with_a_dendritic_photosensitizer_ L2 - https://doi.org/10.1021/nl051679d DB - PRIME DP - Unbound Medicine ER -