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Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer.
Nano Lett. 2005 Dec; 5(12):2426-31.NL

Abstract

Photodynamic therapy (PDT) for exudative age-related macular degeneration (AMD) was evaluated using a supramolecular nanomedical device, that is, a novel dendritic photosensitizer (DP) encapsulated by a polymeric micelle formulation. The characteristic dendritic structure of the DP prevents aggregation of its core sensitizer, thereby inducing a highly effective photochemical reaction. With its highly selective accumulation on choroidal neovascularization (CNV) lesions, this treatment resulted in a remarkably efficacious CNV occlusion with minimal unfavorable phototoxicity.

Authors+Show Affiliations

Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16351191

Citation

Ideta, Ryuichi, et al. "Nanotechnology-based Photodynamic Therapy for Neovascular Disease Using a Supramolecular Nanocarrier Loaded With a Dendritic Photosensitizer." Nano Letters, vol. 5, no. 12, 2005, pp. 2426-31.
Ideta R, Tasaka F, Jang WD, et al. Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer. Nano Lett. 2005;5(12):2426-31.
Ideta, R., Tasaka, F., Jang, W. D., Nishiyama, N., Zhang, G. D., Harada, A., Yanagi, Y., Tamaki, Y., Aida, T., & Kataoka, K. (2005). Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer. Nano Letters, 5(12), 2426-31.
Ideta R, et al. Nanotechnology-based Photodynamic Therapy for Neovascular Disease Using a Supramolecular Nanocarrier Loaded With a Dendritic Photosensitizer. Nano Lett. 2005;5(12):2426-31. PubMed PMID: 16351191.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer. AU - Ideta,Ryuichi, AU - Tasaka,Fumitaka, AU - Jang,Woo-Dong, AU - Nishiyama,Nobuhiro, AU - Zhang,Guo-Dong, AU - Harada,Atsushi, AU - Yanagi,Yasuo, AU - Tamaki,Yasuhiro, AU - Aida,Takuzo, AU - Kataoka,Kazunori, PY - 2005/12/15/pubmed PY - 2006/1/24/medline PY - 2005/12/15/entrez SP - 2426 EP - 31 JF - Nano letters JO - Nano Lett VL - 5 IS - 12 N2 - Photodynamic therapy (PDT) for exudative age-related macular degeneration (AMD) was evaluated using a supramolecular nanomedical device, that is, a novel dendritic photosensitizer (DP) encapsulated by a polymeric micelle formulation. The characteristic dendritic structure of the DP prevents aggregation of its core sensitizer, thereby inducing a highly effective photochemical reaction. With its highly selective accumulation on choroidal neovascularization (CNV) lesions, this treatment resulted in a remarkably efficacious CNV occlusion with minimal unfavorable phototoxicity. SN - 1530-6984 UR - https://www.unboundmedicine.com/medline/citation/16351191/Nanotechnology_based_photodynamic_therapy_for_neovascular_disease_using_a_supramolecular_nanocarrier_loaded_with_a_dendritic_photosensitizer_ L2 - https://doi.org/10.1021/nl051679d DB - PRIME DP - Unbound Medicine ER -