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Intakes of selected nutrients, foods, and phytochemicals and prostate cancer risk in western New York.

Abstract

A number of epidemiological studies have suggested that diet may affect the etiology of prostate cancer, but few have investigated the impact of phytochemical intakes on this cancer. We conducted a case-control study of diet and prostate cancer in western New York involving 433 men with primary, histologically confirmed prostate cancer and 538 population-based controls, frequency matched to cases on age and county of residence. Diet was assessed with a detailed food-frequency questionnaire. We calculated daily intakes of nutrients and the phytochemicals beta-sitosterol, campesterol, stigmasterol, total phytosterols, total lignan precursors, quercetin, and kaempferol based on published food composition data. Odds ratios (ORs) and 95% confidence intervals (CIs) describing the association of prostate cancer risk with selected nutrients, phytochemicals, and food groups were estimated with unconditional logistic regression. Compared with men in the lowest quartile of intake, reduced risks were observed for men in the highest quartile of intake of vitamin C (OR = 0.49; 95% CI = 0.33-0.74), beta-carotene (OR = 0.53; 95% CI = 0.36-0.79), alpha-carotene (OR = 0.67; 95% CI = 0.47-0.97), lutein (OR = 0.55; 95% CI = 0.37-0.81), lycopene (OR = 0.62; 95% CI = 0.42-0.92), total lignan precursors (OR = 0.66; 95% CI = 0.47-0.94), quercetin (OR = 0.64; 95% CI = 0.44-0.92), and total vegetables (OR = 0.53; 95% CI = 0.36-0.79), but weak increased risks were observed for snacks and sweets (OR = 1.46; 95% CI = 0.95-2.23). Estimates associated with nutrients and phytochemicals were attenuated after adjustment for total vegetable intake. Nevertheless, our results support the hypothesis that a phytochemical-rich, plant-based diet is of importance in reducing risks of hormone-related neoplasms.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. susan.mccann@roswellpark.org

    , , , , , ,

    Source

    Nutrition and cancer 53:1 2005 pg 33-41

    MeSH

    Aged
    Case-Control Studies
    Confidence Intervals
    Diet
    Diet Surveys
    Fruit
    Humans
    Logistic Models
    Male
    Middle Aged
    New York
    Odds Ratio
    Prostatic Neoplasms
    Risk Factors
    Surveys and Questionnaires
    Vegetables

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    16351504

    Citation

    McCann, Susan E., et al. "Intakes of Selected Nutrients, Foods, and Phytochemicals and Prostate Cancer Risk in Western New York." Nutrition and Cancer, vol. 53, no. 1, 2005, pp. 33-41.
    McCann SE, Ambrosone CB, Moysich KB, et al. Intakes of selected nutrients, foods, and phytochemicals and prostate cancer risk in western New York. Nutr Cancer. 2005;53(1):33-41.
    McCann, S. E., Ambrosone, C. B., Moysich, K. B., Brasure, J., Marshall, J. R., Freudenheim, J. L., ... Graham, S. (2005). Intakes of selected nutrients, foods, and phytochemicals and prostate cancer risk in western New York. Nutrition and Cancer, 53(1), pp. 33-41.
    McCann SE, et al. Intakes of Selected Nutrients, Foods, and Phytochemicals and Prostate Cancer Risk in Western New York. Nutr Cancer. 2005;53(1):33-41. PubMed PMID: 16351504.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Intakes of selected nutrients, foods, and phytochemicals and prostate cancer risk in western New York. AU - McCann,Susan E, AU - Ambrosone,Christine B, AU - Moysich,Kirsten B, AU - Brasure,John, AU - Marshall,James R, AU - Freudenheim,Jo L, AU - Wilkinson,Gregg S, AU - Graham,Saxon, PY - 2005/12/15/pubmed PY - 2006/6/16/medline PY - 2005/12/15/entrez SP - 33 EP - 41 JF - Nutrition and cancer JO - Nutr Cancer VL - 53 IS - 1 N2 - A number of epidemiological studies have suggested that diet may affect the etiology of prostate cancer, but few have investigated the impact of phytochemical intakes on this cancer. We conducted a case-control study of diet and prostate cancer in western New York involving 433 men with primary, histologically confirmed prostate cancer and 538 population-based controls, frequency matched to cases on age and county of residence. Diet was assessed with a detailed food-frequency questionnaire. We calculated daily intakes of nutrients and the phytochemicals beta-sitosterol, campesterol, stigmasterol, total phytosterols, total lignan precursors, quercetin, and kaempferol based on published food composition data. Odds ratios (ORs) and 95% confidence intervals (CIs) describing the association of prostate cancer risk with selected nutrients, phytochemicals, and food groups were estimated with unconditional logistic regression. Compared with men in the lowest quartile of intake, reduced risks were observed for men in the highest quartile of intake of vitamin C (OR = 0.49; 95% CI = 0.33-0.74), beta-carotene (OR = 0.53; 95% CI = 0.36-0.79), alpha-carotene (OR = 0.67; 95% CI = 0.47-0.97), lutein (OR = 0.55; 95% CI = 0.37-0.81), lycopene (OR = 0.62; 95% CI = 0.42-0.92), total lignan precursors (OR = 0.66; 95% CI = 0.47-0.94), quercetin (OR = 0.64; 95% CI = 0.44-0.92), and total vegetables (OR = 0.53; 95% CI = 0.36-0.79), but weak increased risks were observed for snacks and sweets (OR = 1.46; 95% CI = 0.95-2.23). Estimates associated with nutrients and phytochemicals were attenuated after adjustment for total vegetable intake. Nevertheless, our results support the hypothesis that a phytochemical-rich, plant-based diet is of importance in reducing risks of hormone-related neoplasms. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/16351504/Intakes_of_selected_nutrients_foods_and_phytochemicals_and_prostate_cancer_risk_in_western_New_York_ L2 - http://www.tandfonline.com/doi/full/10.1207/s15327914nc5301_4 DB - PRIME DP - Unbound Medicine ER -