Tags

Type your tag names separated by a space and hit enter

Folate, vitamin B6, vitamin B12, and vitamin B2 intake, genetic polymorphisms of related enzymes, and risk of colorectal cancer in a hospital-based case-control study in Japan.
Nutr Cancer 2005; 53(1):42-50NC

Abstract

We conducted a case-control study to investigate the association of nutrient intake involved in the one-carbon pathway of folate for DNA methylation and DNA synthesis and the related enzyme genetic polymorphisms with colorectal cancer. Cases were 107 patients newly diagnosed with colorectal cancer. Controls were 224 subjects matched with cases by sex, age, and residential area. Nutrient intake was assessed by a self-administered, semiquantitative food-frequency questionnaire. Four genetic polymorphisms-MTHFR C677T and A1298C, MTRR A66G, and ALDH2 Glu487Lys-were determined using blood samples. Odds ratios were calculated using conditional logistic regression analysis adjusted for smoking, alcohol consumption, body mass index, and dietary fiber intake. Although folate intake was inversely associated with colorectal cancer, this association was attenuated after further controlling for dietary fiber intake. Neither vitamin B6, vitamin B12, nor vitamin B2, nor any genetic polymorphism was significantly associated with colorectal cancer. MTRR polymorphism interacted with the association of folate (P for interaction = 0.04) or vitamin (P for interaction = 0.02) with colorectal cancer, although the other polymorphisms did not interact with any nutrient intake. In conclusion, the study did not support the existing hypothesis of gene-nutrient interaction in colorectal carcinogenesis.

Authors+Show Affiliations

Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tsukjii, Tokyo, Japan.teotani@gan2.res.ncc.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16351505

Citation

Otani, Tetsuya, et al. "Folate, Vitamin B6, Vitamin B12, and Vitamin B2 Intake, Genetic Polymorphisms of Related Enzymes, and Risk of Colorectal Cancer in a Hospital-based Case-control Study in Japan." Nutrition and Cancer, vol. 53, no. 1, 2005, pp. 42-50.
Otani T, Iwasaki M, Hanaoka T, et al. Folate, vitamin B6, vitamin B12, and vitamin B2 intake, genetic polymorphisms of related enzymes, and risk of colorectal cancer in a hospital-based case-control study in Japan. Nutr Cancer. 2005;53(1):42-50.
Otani, T., Iwasaki, M., Hanaoka, T., Kobayashi, M., Ishihara, J., Natsukawa, S., ... Tsugane, S. (2005). Folate, vitamin B6, vitamin B12, and vitamin B2 intake, genetic polymorphisms of related enzymes, and risk of colorectal cancer in a hospital-based case-control study in Japan. Nutrition and Cancer, 53(1), pp. 42-50.
Otani T, et al. Folate, Vitamin B6, Vitamin B12, and Vitamin B2 Intake, Genetic Polymorphisms of Related Enzymes, and Risk of Colorectal Cancer in a Hospital-based Case-control Study in Japan. Nutr Cancer. 2005;53(1):42-50. PubMed PMID: 16351505.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folate, vitamin B6, vitamin B12, and vitamin B2 intake, genetic polymorphisms of related enzymes, and risk of colorectal cancer in a hospital-based case-control study in Japan. AU - Otani,Tetsuya, AU - Iwasaki,Motoki, AU - Hanaoka,Tomoyuki, AU - Kobayashi,Minatsu, AU - Ishihara,Junko, AU - Natsukawa,Syusuke, AU - Shaura,Kozo, AU - Koizumi,Yoichi, AU - Kasuga,Yoshio, AU - Yoshimura,Kimio, AU - Yoshida,Teruhiko, AU - Tsugane,Shoichiro, PY - 2005/12/15/pubmed PY - 2006/6/16/medline PY - 2005/12/15/entrez SP - 42 EP - 50 JF - Nutrition and cancer JO - Nutr Cancer VL - 53 IS - 1 N2 - We conducted a case-control study to investigate the association of nutrient intake involved in the one-carbon pathway of folate for DNA methylation and DNA synthesis and the related enzyme genetic polymorphisms with colorectal cancer. Cases were 107 patients newly diagnosed with colorectal cancer. Controls were 224 subjects matched with cases by sex, age, and residential area. Nutrient intake was assessed by a self-administered, semiquantitative food-frequency questionnaire. Four genetic polymorphisms-MTHFR C677T and A1298C, MTRR A66G, and ALDH2 Glu487Lys-were determined using blood samples. Odds ratios were calculated using conditional logistic regression analysis adjusted for smoking, alcohol consumption, body mass index, and dietary fiber intake. Although folate intake was inversely associated with colorectal cancer, this association was attenuated after further controlling for dietary fiber intake. Neither vitamin B6, vitamin B12, nor vitamin B2, nor any genetic polymorphism was significantly associated with colorectal cancer. MTRR polymorphism interacted with the association of folate (P for interaction = 0.04) or vitamin (P for interaction = 0.02) with colorectal cancer, although the other polymorphisms did not interact with any nutrient intake. In conclusion, the study did not support the existing hypothesis of gene-nutrient interaction in colorectal carcinogenesis. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/16351505/Folate_vitamin_B6_vitamin_B12_and_vitamin_B2_intake_genetic_polymorphisms_of_related_enzymes_and_risk_of_colorectal_cancer_in_a_hospital_based_case_control_study_in_Japan_ L2 - http://www.tandfonline.com/doi/full/10.1207/s15327914nc5301_5 DB - PRIME DP - Unbound Medicine ER -