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Achieving lipid goals in real life: the Dutch DISCOVERY study.
Int J Clin Pract. 2005 Dec; 59(12):1387-94.IJ

Abstract

DISCOVERY Netherlands was an open-label, randomised, multicentre study (D3560/L00003) designed to compare the effects of rosuvastatin with those of atorvastatin, simvastatin or pravastatin on low-density lipoprotein cholesterol (LDL-C) goal achievement in a primary care setting. Patients (n = 1,215) with type IIa or type IIb hypercholesterolaemia and cardiovascular risk of >20% or a history of coronary heart or other atherosclerotic vascular disease were randomised to receive treatment with rosuvastatin 10 mg (n = 621), atorvastatin 10 mg (n = 189), simvastatin 20 mg (n = 194) or pravastatin 40 mg (n = 211) for 12 weeks. Significantly, more patients achieved 1998 and 2003 European LDL-C goals with rosuvastatin than with other statins after 12 weeks (p < 0.001). Rosuvastatin reduced LDL-C and total cholesterol levels significantly more than other statins, both in patients who were statin-naïve and in patients who had received previous statin treatment (p < 0.05). All treatments were similarly well tolerated. In conclusion, greater reductions in LDL-C were achieved with rosuvastatin compared with atorvastatin, simvastatin and pravastatin, enabling more patients to achieve European LDL-C goals.

Authors+Show Affiliations

Zuiderhoed General Practice, 's-Hertogenbosch, Amsterdam, the Netherlands. a.bots@zuiderhoed.nlNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16351669

Citation

Bots, A F E., et al. "Achieving Lipid Goals in Real Life: the Dutch DISCOVERY Study." International Journal of Clinical Practice, vol. 59, no. 12, 2005, pp. 1387-94.
Bots AF, Kastelein JJ, Discovery Netherlands Investigators. Achieving lipid goals in real life: the Dutch DISCOVERY study. Int J Clin Pract. 2005;59(12):1387-94.
Bots, A. F., & Kastelein, J. J. (2005). Achieving lipid goals in real life: the Dutch DISCOVERY study. International Journal of Clinical Practice, 59(12), 1387-94.
Bots AF, Kastelein JJ, Discovery Netherlands Investigators. Achieving Lipid Goals in Real Life: the Dutch DISCOVERY Study. Int J Clin Pract. 2005;59(12):1387-94. PubMed PMID: 16351669.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Achieving lipid goals in real life: the Dutch DISCOVERY study. AU - Bots,A F E, AU - Kastelein,J J P, AU - ,, PY - 2005/12/15/pubmed PY - 2006/5/26/medline PY - 2005/12/15/entrez SP - 1387 EP - 94 JF - International journal of clinical practice JO - Int J Clin Pract VL - 59 IS - 12 N2 - DISCOVERY Netherlands was an open-label, randomised, multicentre study (D3560/L00003) designed to compare the effects of rosuvastatin with those of atorvastatin, simvastatin or pravastatin on low-density lipoprotein cholesterol (LDL-C) goal achievement in a primary care setting. Patients (n = 1,215) with type IIa or type IIb hypercholesterolaemia and cardiovascular risk of >20% or a history of coronary heart or other atherosclerotic vascular disease were randomised to receive treatment with rosuvastatin 10 mg (n = 621), atorvastatin 10 mg (n = 189), simvastatin 20 mg (n = 194) or pravastatin 40 mg (n = 211) for 12 weeks. Significantly, more patients achieved 1998 and 2003 European LDL-C goals with rosuvastatin than with other statins after 12 weeks (p < 0.001). Rosuvastatin reduced LDL-C and total cholesterol levels significantly more than other statins, both in patients who were statin-naïve and in patients who had received previous statin treatment (p < 0.05). All treatments were similarly well tolerated. In conclusion, greater reductions in LDL-C were achieved with rosuvastatin compared with atorvastatin, simvastatin and pravastatin, enabling more patients to achieve European LDL-C goals. SN - 1368-5031 UR - https://www.unboundmedicine.com/medline/citation/16351669/Achieving_lipid_goals_in_real_life:_the_Dutch_DISCOVERY_study_ L2 - https://doi.org/10.1111/j.1368-5031.2005.00708.x DB - PRIME DP - Unbound Medicine ER -