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Insulin action in rats is influenced by amount and composition of dietary fat.

Abstract

The chronic influence of dietary fat composition on obesity and insulin action is not well understood. We examined the effect of amount (20% vs 60% of total calories) and type (saturated vs polyunsaturated) of fat on insulin action and body composition in mature male rats. Six months of feeding a high fat (HF) diet led to obesity and impaired insulin action (determined by a euglycemic-hyperinsulinemic clamp), neither of which were reversed by a subsequent 6 months of feeding a low fat (LF) diet. Within HF fed rats, type of fat did not affect body composition or insulin action. Six months of feeding a low fat diet led to only a slight decline in insulin action, with no difference due to type of dietary fat. From 6-9 months, insulin action became more impaired in LF rats fed the saturated diet than in LF rats fed the polyunsaturated diet. By 12 months, all groups were obese and had a similar impairment in insulin action. The amount and type of fat in the diet did not influence the overall degree of impairment in insulin action but did affect the time course. Both feeding a high fat diet and feeding a low fat saturated diet accelerated the impairment in insulin action relative to rats fed a low fat polyunsaturated fat diet.

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  • Authors+Show Affiliations

    ,

    Department of Pediatrics, Vanderbilt University, Nashville, TN, USA.

    , , ,

    Source

    Obesity research 1:6 1993 Nov pg 481-8

    MeSH

    Adipose Tissue
    Animals
    Blood Glucose
    Body Weight
    Diet, Fat-Restricted
    Dietary Fats
    Dietary Fats, Unsaturated
    Dietary Supplements
    Energy Intake
    Fatty Acids, Unsaturated
    Glucose
    Glucose Clamp Technique
    Glucose Tolerance Test
    Insulin
    Insulin Resistance
    Lipid Metabolism
    Male
    Obesity
    Rats
    Rats, Wistar
    Time Factors
    Vitamins
    Weight Gain

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    16353334

    Citation

    Yakubu, F, et al. "Insulin Action in Rats Is Influenced By Amount and Composition of Dietary Fat." Obesity Research, vol. 1, no. 6, 1993, pp. 481-8.
    Yakubu F, Lin D, Peters JC, et al. Insulin action in rats is influenced by amount and composition of dietary fat. Obes Res. 1993;1(6):481-8.
    Yakubu, F., Lin, D., Peters, J. C., Reed, G. W., & Hill, J. O. (1993). Insulin action in rats is influenced by amount and composition of dietary fat. Obesity Research, 1(6), pp. 481-8.
    Yakubu F, et al. Insulin Action in Rats Is Influenced By Amount and Composition of Dietary Fat. Obes Res. 1993;1(6):481-8. PubMed PMID: 16353334.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Insulin action in rats is influenced by amount and composition of dietary fat. AU - Yakubu,F, AU - Lin,D, AU - Peters,J C, AU - Reed,G W, AU - Hill,J O, PY - 1993/11/1/pubmed PY - 2006/2/7/medline PY - 1993/11/1/entrez SP - 481 EP - 8 JF - Obesity research JO - Obes. Res. VL - 1 IS - 6 N2 - The chronic influence of dietary fat composition on obesity and insulin action is not well understood. We examined the effect of amount (20% vs 60% of total calories) and type (saturated vs polyunsaturated) of fat on insulin action and body composition in mature male rats. Six months of feeding a high fat (HF) diet led to obesity and impaired insulin action (determined by a euglycemic-hyperinsulinemic clamp), neither of which were reversed by a subsequent 6 months of feeding a low fat (LF) diet. Within HF fed rats, type of fat did not affect body composition or insulin action. Six months of feeding a low fat diet led to only a slight decline in insulin action, with no difference due to type of dietary fat. From 6-9 months, insulin action became more impaired in LF rats fed the saturated diet than in LF rats fed the polyunsaturated diet. By 12 months, all groups were obese and had a similar impairment in insulin action. The amount and type of fat in the diet did not influence the overall degree of impairment in insulin action but did affect the time course. Both feeding a high fat diet and feeding a low fat saturated diet accelerated the impairment in insulin action relative to rats fed a low fat polyunsaturated fat diet. SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/16353334/Insulin_action_in_rats_is_influenced_by_amount_and_composition_of_dietary_fat_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1071-7323&date=1993&volume=1&issue=6&spage=481 DB - PRIME DP - Unbound Medicine ER -