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In vitro and in vivo evaluation of guar gum matrix tablets for oral controlled release of water-soluble diltiazem hydrochloride.
AAPS PharmSciTech. 2005 Jul 14; 6(1):E14-21.AP

Abstract

The objective of the study was to develop guar gum matrix tablets for oral controlled release of water-soluble diltiazem hydrochloride. Matrix tablets of diltiazem hydrochloride, using various viscosity grades of guar gum in 2 proportions, were prepared by wet granulation method and subjected to in vitro drug release studies. Diltiazem hydrochloride matrix tablets containing either 30% wt/wt low-viscosity (LM1), 40% wt/wt medium-viscosity (MM2), or 50% wt/wt high-viscosity (HM2) guar gum showed controlled release. The drug release from all guar gum matrix tablets followed first-order kinetics via Fickian-diffusion. Further, the results of in vitro drug release studies in simulated gastrointestinal and colonic fluids showed that HM2 tablets provided controlled release comparable with marketed sustained release diltiazem hydrochloride tablets (D-SR tablets). Guar gum matrix tablets HM2 showed no change in physical appearance, drug content, or in dissolution pattern after storage at 40 degrees C/relative humidity 75% for 6 months. When subjected to in vivo pharmacokinetic evaluation in healthy volunteers, the HM2 tablets provided a slow and prolonged drug release when compared with D-SR tablets. Based on the results of in vitro and in vivo studies it was concluded that that guar gum matrix tablets provided oral controlled release of water-soluble diltiazem hydrochloride.

Authors+Show Affiliations

Department of Pharmaceutics, Faculty of Pharmacy, Health Science Center, Kuwait University, Kuwait.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16353958

Citation

Al-Saidan, Saleh M., et al. "In Vitro and in Vivo Evaluation of Guar Gum Matrix Tablets for Oral Controlled Release of Water-soluble Diltiazem Hydrochloride." AAPS PharmSciTech, vol. 6, no. 1, 2005, pp. E14-21.
Al-Saidan SM, Krishnaiah YS, Patro SS, et al. In vitro and in vivo evaluation of guar gum matrix tablets for oral controlled release of water-soluble diltiazem hydrochloride. AAPS PharmSciTech. 2005;6(1):E14-21.
Al-Saidan, S. M., Krishnaiah, Y. S., Patro, S. S., & Satyanaryana, V. (2005). In vitro and in vivo evaluation of guar gum matrix tablets for oral controlled release of water-soluble diltiazem hydrochloride. AAPS PharmSciTech, 6(1), E14-21.
Al-Saidan SM, et al. In Vitro and in Vivo Evaluation of Guar Gum Matrix Tablets for Oral Controlled Release of Water-soluble Diltiazem Hydrochloride. AAPS PharmSciTech. 2005 Jul 14;6(1):E14-21. PubMed PMID: 16353958.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro and in vivo evaluation of guar gum matrix tablets for oral controlled release of water-soluble diltiazem hydrochloride. AU - Al-Saidan,Saleh M, AU - Krishnaiah,Yellela S R, AU - Patro,Srinivas S, AU - Satyanaryana,Vemulapalli, Y1 - 2005/07/14/ PY - 2005/12/16/pubmed PY - 2006/1/19/medline PY - 2005/12/16/entrez SP - E14 EP - 21 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 6 IS - 1 N2 - The objective of the study was to develop guar gum matrix tablets for oral controlled release of water-soluble diltiazem hydrochloride. Matrix tablets of diltiazem hydrochloride, using various viscosity grades of guar gum in 2 proportions, were prepared by wet granulation method and subjected to in vitro drug release studies. Diltiazem hydrochloride matrix tablets containing either 30% wt/wt low-viscosity (LM1), 40% wt/wt medium-viscosity (MM2), or 50% wt/wt high-viscosity (HM2) guar gum showed controlled release. The drug release from all guar gum matrix tablets followed first-order kinetics via Fickian-diffusion. Further, the results of in vitro drug release studies in simulated gastrointestinal and colonic fluids showed that HM2 tablets provided controlled release comparable with marketed sustained release diltiazem hydrochloride tablets (D-SR tablets). Guar gum matrix tablets HM2 showed no change in physical appearance, drug content, or in dissolution pattern after storage at 40 degrees C/relative humidity 75% for 6 months. When subjected to in vivo pharmacokinetic evaluation in healthy volunteers, the HM2 tablets provided a slow and prolonged drug release when compared with D-SR tablets. Based on the results of in vitro and in vivo studies it was concluded that that guar gum matrix tablets provided oral controlled release of water-soluble diltiazem hydrochloride. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/16353958/In_vitro_and_in_vivo_evaluation_of_guar_gum_matrix_tablets_for_oral_controlled_release_of_water_soluble_diltiazem_hydrochloride_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/16353958/ DB - PRIME DP - Unbound Medicine ER -