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Preparation and characterization of etoricoxib solid dispersions using lipid carriers by spray drying technique.
AAPS PharmSciTech. 2005 Oct 19; 6(3):E405-12.AP

Abstract

The basic objectives of this study were to prepare and characterize solid dispersions of poorly water-soluble drug etoricoxib using lipid carriers by spray drying technique. The properties of solid dispersions were studied by diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), differential scanning calorimetry (DSC), hot-stage microscopy (HSM), radiograph powder diffraction (XRPD), and dissolution studies. The absence of etoricoxib peaks in XRPD profiles of solid dispersions suggests the transformation of crystalline etoricoxib into an amorphous form. In the HSM examination of solid dispersions, the dissolution of drug in the lipid carriers was observed, which was also confirmed by the absence of etoricoxib peak in DSC curves of solid dispersions. The DRIFTS spectra revealed the presence of hydrogen bonding in solid dispersions. The in vitro dissolution test showed a significant increase in the dissolution rate of solid dispersions as compared with pure etoricoxib, spray-dried etoricoxib, and physical mixtures of drug with lipid carriers. Therefore, the dissolution rate of poorly water-soluble drug etoricoxib can be significantly enhanced by the preparation of solid dispersions using lipid carriers by spray drying technique.

Authors+Show Affiliations

Department of Pharmaceutics, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Erandwane, Pune-411038, Maharashtra, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16353998

Citation

Chauhan, Bhaskar, et al. "Preparation and Characterization of Etoricoxib Solid Dispersions Using Lipid Carriers By Spray Drying Technique." AAPS PharmSciTech, vol. 6, no. 3, 2005, pp. E405-12.
Chauhan B, Shimpi S, Paradkar A. Preparation and characterization of etoricoxib solid dispersions using lipid carriers by spray drying technique. AAPS PharmSciTech. 2005;6(3):E405-12.
Chauhan, B., Shimpi, S., & Paradkar, A. (2005). Preparation and characterization of etoricoxib solid dispersions using lipid carriers by spray drying technique. AAPS PharmSciTech, 6(3), E405-12.
Chauhan B, Shimpi S, Paradkar A. Preparation and Characterization of Etoricoxib Solid Dispersions Using Lipid Carriers By Spray Drying Technique. AAPS PharmSciTech. 2005 Oct 19;6(3):E405-12. PubMed PMID: 16353998.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and characterization of etoricoxib solid dispersions using lipid carriers by spray drying technique. AU - Chauhan,Bhaskar, AU - Shimpi,Shyam, AU - Paradkar,Anant, Y1 - 2005/10/19/ PY - 2005/12/16/pubmed PY - 2006/4/7/medline PY - 2005/12/16/entrez SP - E405 EP - 12 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 6 IS - 3 N2 - The basic objectives of this study were to prepare and characterize solid dispersions of poorly water-soluble drug etoricoxib using lipid carriers by spray drying technique. The properties of solid dispersions were studied by diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), differential scanning calorimetry (DSC), hot-stage microscopy (HSM), radiograph powder diffraction (XRPD), and dissolution studies. The absence of etoricoxib peaks in XRPD profiles of solid dispersions suggests the transformation of crystalline etoricoxib into an amorphous form. In the HSM examination of solid dispersions, the dissolution of drug in the lipid carriers was observed, which was also confirmed by the absence of etoricoxib peak in DSC curves of solid dispersions. The DRIFTS spectra revealed the presence of hydrogen bonding in solid dispersions. The in vitro dissolution test showed a significant increase in the dissolution rate of solid dispersions as compared with pure etoricoxib, spray-dried etoricoxib, and physical mixtures of drug with lipid carriers. Therefore, the dissolution rate of poorly water-soluble drug etoricoxib can be significantly enhanced by the preparation of solid dispersions using lipid carriers by spray drying technique. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/16353998/Preparation_and_characterization_of_etoricoxib_solid_dispersions_using_lipid_carriers_by_spray_drying_technique_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/16353998/ DB - PRIME DP - Unbound Medicine ER -