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Lacrimal gland orbital lobe cysts associated with MALT lymphoma and primary Sjögren's syndrome.
Orbit 2005; 24(4):257-63O

Abstract

PURPOSE

To describe, for the first time, the occurrence of a large cyst in the orbital lobe of the lacrimal gland in association with marginal zone B-cell MALT lymphoma in three female patients, two of whom also had primary Sjögren's syndrome.

METHODS

Retrospective case note review.

RESULTS

Three female patients, aged 35, 41 and 47 years, presented with progressive proptosis caused by an enlarging cyst within the orbital lobe of the lacrimal gland. Two of the patients had primary Sjögren's syndrome. Excision of the cyst and part of the lacrimal gland revealed marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type within the gland or wall of the cyst in all cases. The cysts were partially lined by ductular epithelium. One patient had systemic lymphoma, was treated with chemotherapy and remains in remission one year later; the other two had disease apparently confined to the lacrimal gland and are disease-free at 9 months and at three years after local irradiation, respectively.

CONCLUSION

To our knowledge, these are the first reported cases of cysts affecting the orbital lobe of the lacrimal gland in patients with B-cell MALT lymphoma of the gland. Although cystic changes have been described in other exocrine glands, lung and thymus in patients with Sjögren's syndrome, this association has also not been described in the lacrimal gland before.

Authors+Show Affiliations

Orbital, Plastic and Lacrimal Clinic, Royal Victorian Eye and Ear Hospital, Melbourne, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16354635

Citation

Cassidy, Dermot T., et al. "Lacrimal Gland Orbital Lobe Cysts Associated With MALT Lymphoma and Primary Sjögren's Syndrome." Orbit (Amsterdam, Netherlands), vol. 24, no. 4, 2005, pp. 257-63.
Cassidy DT, McKelvie P, Harris GJ, et al. Lacrimal gland orbital lobe cysts associated with MALT lymphoma and primary Sjögren's syndrome. Orbit. 2005;24(4):257-63.
Cassidy, D. T., McKelvie, P., Harris, G. J., Rose, G. E., & McNab, A. A. (2005). Lacrimal gland orbital lobe cysts associated with MALT lymphoma and primary Sjögren's syndrome. Orbit (Amsterdam, Netherlands), 24(4), pp. 257-63.
Cassidy DT, et al. Lacrimal Gland Orbital Lobe Cysts Associated With MALT Lymphoma and Primary Sjögren's Syndrome. Orbit. 2005;24(4):257-63. PubMed PMID: 16354635.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lacrimal gland orbital lobe cysts associated with MALT lymphoma and primary Sjögren's syndrome. AU - Cassidy,Dermot T, AU - McKelvie,Penny, AU - Harris,Gerald J, AU - Rose,Geoffrey E, AU - McNab,Alan A, PY - 2005/12/16/pubmed PY - 2006/3/24/medline PY - 2005/12/16/entrez SP - 257 EP - 63 JF - Orbit (Amsterdam, Netherlands) JO - Orbit VL - 24 IS - 4 N2 - PURPOSE: To describe, for the first time, the occurrence of a large cyst in the orbital lobe of the lacrimal gland in association with marginal zone B-cell MALT lymphoma in three female patients, two of whom also had primary Sjögren's syndrome. METHODS: Retrospective case note review. RESULTS: Three female patients, aged 35, 41 and 47 years, presented with progressive proptosis caused by an enlarging cyst within the orbital lobe of the lacrimal gland. Two of the patients had primary Sjögren's syndrome. Excision of the cyst and part of the lacrimal gland revealed marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type within the gland or wall of the cyst in all cases. The cysts were partially lined by ductular epithelium. One patient had systemic lymphoma, was treated with chemotherapy and remains in remission one year later; the other two had disease apparently confined to the lacrimal gland and are disease-free at 9 months and at three years after local irradiation, respectively. CONCLUSION: To our knowledge, these are the first reported cases of cysts affecting the orbital lobe of the lacrimal gland in patients with B-cell MALT lymphoma of the gland. Although cystic changes have been described in other exocrine glands, lung and thymus in patients with Sjögren's syndrome, this association has also not been described in the lacrimal gland before. SN - 0167-6830 UR - https://www.unboundmedicine.com/medline/citation/16354635/Lacrimal_gland_orbital_lobe_cysts_associated_with_MALT_lymphoma_and_primary_Sjögren's_syndrome_ L2 - http://www.tandfonline.com/doi/full/10.1080/01676830590922084 DB - PRIME DP - Unbound Medicine ER -