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Hendra and Nipah viruses: different and dangerous.
Nat Rev Microbiol. 2006 Jan; 4(1):23-35.NR

Abstract

Hendra virus and Nipah virus are highly pathogenic paramyxoviruses that have recently emerged from flying foxes to cause serious disease outbreaks in humans and livestock in Australia, Malaysia, Singapore and Bangladesh. Their unique genetic constitution, high virulence and wide host range set them apart from other paramyxoviruses. These features led to their classification into the new genus Henipavirus within the family Paramyxoviridae and to their designation as Biosafety Level 4 pathogens. This review provides an overview of henipaviruses and the types of infection they cause, and describes how studies on the structure and function of henipavirus proteins expressed from cloned genes have provided insights into the unique biological properties of these emerging human pathogens.

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Authors+Show Affiliations

Eaton BT
Australian Animal Health Laboratory, Commonwealth Scientific and Industrial Research Organization, 5 Portarlington Road, Geelong, Victoria 3220, Australia. Bryan.Eaton@csiro.au
Broder CC
No affiliation info available
Middleton D
No affiliation info available
Wang LF
No affiliation info available

MeSH

AnimalsGenome, ViralHendra VirusHenipavirus InfectionsHumansMicroscopy, ElectronNipah VirusSignal TransductionViral ProteinsVirulence

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

16357858

Citation

Eaton, Bryan T., et al. "Hendra and Nipah Viruses: Different and Dangerous." Nature Reviews. Microbiology, vol. 4, no. 1, 2006, pp. 23-35.
Eaton BT, Broder CC, Middleton D, et al. Hendra and Nipah viruses: different and dangerous. Nat Rev Microbiol. 2006;4(1):23-35.
Eaton, B. T., Broder, C. C., Middleton, D., & Wang, L. F. (2006). Hendra and Nipah viruses: different and dangerous. Nature Reviews. Microbiology, 4(1), 23-35.
Eaton BT, et al. Hendra and Nipah Viruses: Different and Dangerous. Nat Rev Microbiol. 2006;4(1):23-35. PubMed PMID: 16357858.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hendra and Nipah viruses: different and dangerous. AU - Eaton,Bryan T, AU - Broder,Christopher C, AU - Middleton,Deborah, AU - Wang,Lin-Fa, PY - 2005/12/17/pubmed PY - 2006/1/26/medline PY - 2005/12/17/entrez SP - 23 EP - 35 JF - Nature reviews. Microbiology JO - Nat Rev Microbiol VL - 4 IS - 1 N2 - Hendra virus and Nipah virus are highly pathogenic paramyxoviruses that have recently emerged from flying foxes to cause serious disease outbreaks in humans and livestock in Australia, Malaysia, Singapore and Bangladesh. Their unique genetic constitution, high virulence and wide host range set them apart from other paramyxoviruses. These features led to their classification into the new genus Henipavirus within the family Paramyxoviridae and to their designation as Biosafety Level 4 pathogens. This review provides an overview of henipaviruses and the types of infection they cause, and describes how studies on the structure and function of henipavirus proteins expressed from cloned genes have provided insights into the unique biological properties of these emerging human pathogens. SN - 1740-1526 UR - https://www.unboundmedicine.com/medline/citation/16357858/Hendra_and_Nipah_viruses:_different_and_dangerous_ DB - PRIME DP - Unbound Medicine ER -