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Apolipoprotein E and alpha brain rhythms in mild cognitive impairment: a multicentric electroencephalogram study.
Ann Neurol. 2006 Feb; 59(2):323-34.AN

Abstract

OBJECTIVE

Relationships between the apolipoprotein E epsilon4 allele and electroencephalographic (EEG) rhythmicity have been demonstrated in Alzheimer's disease (AD) patients but not in the preclinical stage prodromic to it, namely, mild cognitive impairment (MCI). The present multicentric EEG study tested the hypothesis that presence of epsilon4 affects sources of resting EEG rhythms in both MCI and AD subjects.

METHODS

We enrolled 89 MCI subjects (34.8% with epsilon4) and 103 AD patients (50.4% with epsilon4). Resting eyes-closed EEG data were recorded for all subjects. EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13Hz), beta 1 (13-20 Hz), and beta 2 (20-30 Hz). EEG cortical sources were estimated by low-resolution brain electromagnetic tomography.

RESULTS

Results showed that amplitude of alpha 1 and 2 sources in occipital, temporal, and limbic areas was lower in subjects carrying the epsilon4 allele than in those not carrying the epsilon4 allele (p < 0.01). This was true for both MCI and AD. For the first time to our knowledge, a relationship was shown between ApoE genotype and global neurophysiological phenotype (ie, cortical alpha rhythmicity) in a preclinical AD condition, MCI, in addition to clinically manifest AD.

INTERPRETATION

Such a demonstration motivates future genotype-EEG phenotype studies for the early prediction of AD conversion in individual MCI subjects.

Authors+Show Affiliations

Dipartimento di Fisiologia Umana e Farmacologia, Universitá La Sapienza, Rome, Italy. claudio.babiloni@uniroma1.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study

Language

eng

PubMed ID

16358334

Citation

Babiloni, Claudio, et al. "Apolipoprotein E and Alpha Brain Rhythms in Mild Cognitive Impairment: a Multicentric Electroencephalogram Study." Annals of Neurology, vol. 59, no. 2, 2006, pp. 323-34.
Babiloni C, Benussi L, Binetti G, et al. Apolipoprotein E and alpha brain rhythms in mild cognitive impairment: a multicentric electroencephalogram study. Ann Neurol. 2006;59(2):323-34.
Babiloni, C., Benussi, L., Binetti, G., Cassetta, E., Dal Forno, G., Del Percio, C., Ferreri, F., Ferri, R., Frisoni, G., Ghidoni, R., Miniussi, C., Rodriguez, G., Romani, G. L., Squitti, R., Ventriglia, M. C., & Rossini, P. M. (2006). Apolipoprotein E and alpha brain rhythms in mild cognitive impairment: a multicentric electroencephalogram study. Annals of Neurology, 59(2), 323-34.
Babiloni C, et al. Apolipoprotein E and Alpha Brain Rhythms in Mild Cognitive Impairment: a Multicentric Electroencephalogram Study. Ann Neurol. 2006;59(2):323-34. PubMed PMID: 16358334.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E and alpha brain rhythms in mild cognitive impairment: a multicentric electroencephalogram study. AU - Babiloni,Claudio, AU - Benussi,Luisa, AU - Binetti,Giuliano, AU - Cassetta,Emanuele, AU - Dal Forno,Gloria, AU - Del Percio,Claudio, AU - Ferreri,Florinda, AU - Ferri,Raffaele, AU - Frisoni,Giovanni, AU - Ghidoni,Roberta, AU - Miniussi,Carlo, AU - Rodriguez,Guido, AU - Romani,Gian Luca, AU - Squitti,Rosanna, AU - Ventriglia,Maria Carla, AU - Rossini,Paolo M, PY - 2005/12/17/pubmed PY - 2006/4/28/medline PY - 2005/12/17/entrez SP - 323 EP - 34 JF - Annals of neurology JO - Ann Neurol VL - 59 IS - 2 N2 - OBJECTIVE: Relationships between the apolipoprotein E epsilon4 allele and electroencephalographic (EEG) rhythmicity have been demonstrated in Alzheimer's disease (AD) patients but not in the preclinical stage prodromic to it, namely, mild cognitive impairment (MCI). The present multicentric EEG study tested the hypothesis that presence of epsilon4 affects sources of resting EEG rhythms in both MCI and AD subjects. METHODS: We enrolled 89 MCI subjects (34.8% with epsilon4) and 103 AD patients (50.4% with epsilon4). Resting eyes-closed EEG data were recorded for all subjects. EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13Hz), beta 1 (13-20 Hz), and beta 2 (20-30 Hz). EEG cortical sources were estimated by low-resolution brain electromagnetic tomography. RESULTS: Results showed that amplitude of alpha 1 and 2 sources in occipital, temporal, and limbic areas was lower in subjects carrying the epsilon4 allele than in those not carrying the epsilon4 allele (p < 0.01). This was true for both MCI and AD. For the first time to our knowledge, a relationship was shown between ApoE genotype and global neurophysiological phenotype (ie, cortical alpha rhythmicity) in a preclinical AD condition, MCI, in addition to clinically manifest AD. INTERPRETATION: Such a demonstration motivates future genotype-EEG phenotype studies for the early prediction of AD conversion in individual MCI subjects. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/16358334/Apolipoprotein_E_and_alpha_brain_rhythms_in_mild_cognitive_impairment:_a_multicentric_electroencephalogram_study_ L2 - https://doi.org/10.1002/ana.20724 DB - PRIME DP - Unbound Medicine ER -