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Rosiglitazone protects human neuroblastoma SH-SY5Y cells against acetaldehyde-induced cytotoxicity.
Biochem Biophys Res Commun. 2006 Feb 03; 340(1):221-7.BB

Abstract

Acetaldehyde, an inhibitor of mitochondrial function, has been widely used as a neurotoxin because it elicits a severe Parkinson's disease-like syndrome with elevation of the intracellular reactive oxygen species level and apoptosis. Rosiglitazone, a peroxisome proliferator-activated receptor-gamma agonist, has been known to show various non-hypoglycemic effects, including anti-inflammatory, anti-atherogenic, and anti-apoptotic. In this study, we investigated the protective effects of rosiglitazone on acetaldehyde-induced apoptosis in human neuroblastoma SH-SY5Y cells and attempted to examine its mechanism. Acetaldehyde-induced apoptosis was moderately reversed by rosiglitazone treatment. Our results suggest that the protective effects of rosiglitazone on acetaldehyde-induced apoptosis may be ascribed to ability to induce the expression of anti-oxidant enzymes and to regulate Bcl-2 and Bax expression. These data indicate that rosiglitazone may provide a useful therapeutic strategy for the prevention of progressive neurodegenerative disease such as Parkinson's disease.

Authors+Show Affiliations

The Brain Korea 21 Project for Medical Science, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16360119

Citation

Jung, Tae Woo, et al. "Rosiglitazone Protects Human Neuroblastoma SH-SY5Y Cells Against Acetaldehyde-induced Cytotoxicity." Biochemical and Biophysical Research Communications, vol. 340, no. 1, 2006, pp. 221-7.
Jung TW, Lee JY, Shim WS, et al. Rosiglitazone protects human neuroblastoma SH-SY5Y cells against acetaldehyde-induced cytotoxicity. Biochem Biophys Res Commun. 2006;340(1):221-7.
Jung, T. W., Lee, J. Y., Shim, W. S., Kang, E. S., Kim, S. K., Ahn, C. W., Lee, H. C., & Cha, B. S. (2006). Rosiglitazone protects human neuroblastoma SH-SY5Y cells against acetaldehyde-induced cytotoxicity. Biochemical and Biophysical Research Communications, 340(1), 221-7.
Jung TW, et al. Rosiglitazone Protects Human Neuroblastoma SH-SY5Y Cells Against Acetaldehyde-induced Cytotoxicity. Biochem Biophys Res Commun. 2006 Feb 3;340(1):221-7. PubMed PMID: 16360119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rosiglitazone protects human neuroblastoma SH-SY5Y cells against acetaldehyde-induced cytotoxicity. AU - Jung,Tae Woo, AU - Lee,Ji Young, AU - Shim,Wan Sub, AU - Kang,Eun Seok, AU - Kim,Soo Kyung, AU - Ahn,Chul Woo, AU - Lee,Hyun Chul, AU - Cha,Bong Soo, Y1 - 2005/12/09/ PY - 2005/11/21/received PY - 2005/11/22/accepted PY - 2005/12/20/pubmed PY - 2006/3/1/medline PY - 2005/12/20/entrez SP - 221 EP - 7 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 340 IS - 1 N2 - Acetaldehyde, an inhibitor of mitochondrial function, has been widely used as a neurotoxin because it elicits a severe Parkinson's disease-like syndrome with elevation of the intracellular reactive oxygen species level and apoptosis. Rosiglitazone, a peroxisome proliferator-activated receptor-gamma agonist, has been known to show various non-hypoglycemic effects, including anti-inflammatory, anti-atherogenic, and anti-apoptotic. In this study, we investigated the protective effects of rosiglitazone on acetaldehyde-induced apoptosis in human neuroblastoma SH-SY5Y cells and attempted to examine its mechanism. Acetaldehyde-induced apoptosis was moderately reversed by rosiglitazone treatment. Our results suggest that the protective effects of rosiglitazone on acetaldehyde-induced apoptosis may be ascribed to ability to induce the expression of anti-oxidant enzymes and to regulate Bcl-2 and Bax expression. These data indicate that rosiglitazone may provide a useful therapeutic strategy for the prevention of progressive neurodegenerative disease such as Parkinson's disease. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/16360119/Rosiglitazone_protects_human_neuroblastoma_SH_SY5Y_cells_against_acetaldehyde_induced_cytotoxicity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(05)02698-7 DB - PRIME DP - Unbound Medicine ER -