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Energy cost of activity and exercise in children and adolescents with cystic fibrosis.
J Cyst Fibros 2006; 5(1):53-8JC

Abstract

In cystic fibrosis (CF), perturbations of total daily energy expenditure (TDEE) may be a major determinant of altered nutrition and growth. Measurement of TDEE is problematic, though the flex-heart rate method (FHRM) provides a close estimation of TDEE, as compared to the cost-prohibitive, gold standard, the double-labeled water method, and permits estimates of the energy cost of daily activities (ECA) above resting energy expenditure (REE). We hypothesize that alterations in ECA affects TDEE in CF.

PURPOSE

To measure components of TDEE in adolescents with CF and normal lung function compared with controls, and to determine whether ECA can be improved by diet and exercise.

METHODS

Clinically stable CF subjects (aged 9-13, n=12) and age- and gender-matched controls (n=13) had repeated measurements of TDEE by FHRM, REE, and maximal cardiopulmonary exercise testing (CPET) during a 6-week exercise and diet program.

RESULTS

While the mean REE was similar in both groups, ECA was significantly lower in CF adolescents as compared to controls (p=0.02). During CPET, maximal exercise in CF was characterized by hyperventilation, which was unrelated to ventilation-perfusion mismatching. There were no changes in REE after dietary intervention.

CONCLUSION

ECA in CF adolescents with normal lung function is lower when compared to healthy controls. These findings support the hypothesis that clinically stable patients with CF have inefficient energy metabolism or alternatively conserve energy during activities of daily living.

Authors+Show Affiliations

Department of Pediatrics, Washington University School of Medicine. St. Louis, MO 63011, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16360343

Citation

Johnson, Mark R., et al. "Energy Cost of Activity and Exercise in Children and Adolescents With Cystic Fibrosis." Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society, vol. 5, no. 1, 2006, pp. 53-8.
Johnson MR, Ferkol TW, Shepherd RW. Energy cost of activity and exercise in children and adolescents with cystic fibrosis. J Cyst Fibros. 2006;5(1):53-8.
Johnson, M. R., Ferkol, T. W., & Shepherd, R. W. (2006). Energy cost of activity and exercise in children and adolescents with cystic fibrosis. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society, 5(1), pp. 53-8.
Johnson MR, Ferkol TW, Shepherd RW. Energy Cost of Activity and Exercise in Children and Adolescents With Cystic Fibrosis. J Cyst Fibros. 2006;5(1):53-8. PubMed PMID: 16360343.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Energy cost of activity and exercise in children and adolescents with cystic fibrosis. AU - Johnson,Mark R, AU - Ferkol,Thomas W, AU - Shepherd,Ross W, Y1 - 2005/12/15/ PY - 2005/03/29/received PY - 2005/10/08/revised PY - 2005/10/12/accepted PY - 2005/12/20/pubmed PY - 2006/6/7/medline PY - 2005/12/20/entrez SP - 53 EP - 8 JF - Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society JO - J. Cyst. Fibros. VL - 5 IS - 1 N2 - UNLABELLED: In cystic fibrosis (CF), perturbations of total daily energy expenditure (TDEE) may be a major determinant of altered nutrition and growth. Measurement of TDEE is problematic, though the flex-heart rate method (FHRM) provides a close estimation of TDEE, as compared to the cost-prohibitive, gold standard, the double-labeled water method, and permits estimates of the energy cost of daily activities (ECA) above resting energy expenditure (REE). We hypothesize that alterations in ECA affects TDEE in CF. PURPOSE: To measure components of TDEE in adolescents with CF and normal lung function compared with controls, and to determine whether ECA can be improved by diet and exercise. METHODS: Clinically stable CF subjects (aged 9-13, n=12) and age- and gender-matched controls (n=13) had repeated measurements of TDEE by FHRM, REE, and maximal cardiopulmonary exercise testing (CPET) during a 6-week exercise and diet program. RESULTS: While the mean REE was similar in both groups, ECA was significantly lower in CF adolescents as compared to controls (p=0.02). During CPET, maximal exercise in CF was characterized by hyperventilation, which was unrelated to ventilation-perfusion mismatching. There were no changes in REE after dietary intervention. CONCLUSION: ECA in CF adolescents with normal lung function is lower when compared to healthy controls. These findings support the hypothesis that clinically stable patients with CF have inefficient energy metabolism or alternatively conserve energy during activities of daily living. SN - 1569-1993 UR - https://www.unboundmedicine.com/medline/citation/16360343/Energy_cost_of_activity_and_exercise_in_children_and_adolescents_with_cystic_fibrosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1569-1993(05)00130-X DB - PRIME DP - Unbound Medicine ER -