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The association between polycystic ovaries and endometrial cancer.

Abstract

BACKGROUND

Women with polycystic ovary syndrome (PCOS) are assumed to be at increased risk of endometrial cancer (EC), albeit of a more differentiated type with better prognosis than in normal women. This study was designed to test these assumptions, as evidence for them is lacking.

METHODS

The prevalence of polycystic ovaries (PCO), as a marker of PCOS, was investigated in ovarian sections from 128 women with EC and 83 with benign gynaecological conditions. The expression of the prognostic markers p53, Ki67, Bcl2 and cyclin D1 was also investigated by immunohistochemistry in endometrial tumours from 11 women with PCO and 16 with normal ovaries.

RESULTS

Overall, PCO were similarly prevalent in women with EC (8.6%) and benign controls (8.4%); however, in women aged <50 years, PCO were more prevalent in women with EC (62.5 versus 27.3%, P = 0.033). Cyclin D1-expressing endometrial tumours tended to be more prevalent in women with PCO compared to normal ovaries (36.4 versus 6.25%, respectively, P = 0.071). Bcl2-, p53- and Ki67-expressing tumours were similarly prevalent.

CONCLUSIONS

The association between PCOS and EC appears confined to premenopausal women. The tendency for cyclin D1-expressing endometrial tumours to be more prevalent in women with PCO challenges the assumption that EC prognosis is improved in women with PCOS.

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  • Authors+Show Affiliations

    ,

    University Department of Obstetrics and Gynaecology, Royal Free and University College Medical School, University College London, London, UK.

    , , , , , , ,

    Source

    MeSH

    Adult
    Aged
    Biomarkers, Tumor
    Cyclin D1
    Endometrial Neoplasms
    Female
    Humans
    Immunohistochemistry
    Ki-67 Antigen
    Middle Aged
    Ovary
    Polycystic Ovary Syndrome
    Prognosis
    Proto-Oncogene Proteins
    Risk Factors
    Tumor Suppressor Protein p53

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16361289

    Citation

    Pillay, O C., et al. "The Association Between Polycystic Ovaries and Endometrial Cancer." Human Reproduction (Oxford, England), vol. 21, no. 4, 2006, pp. 924-9.
    Pillay OC, Te Fong LF, Crow JC, et al. The association between polycystic ovaries and endometrial cancer. Hum Reprod. 2006;21(4):924-9.
    Pillay, O. C., Te Fong, L. F., Crow, J. C., Benjamin, E., Mould, T., Atiomo, W., ... Hardiman, P. (2006). The association between polycystic ovaries and endometrial cancer. Human Reproduction (Oxford, England), 21(4), pp. 924-9.
    Pillay OC, et al. The Association Between Polycystic Ovaries and Endometrial Cancer. Hum Reprod. 2006;21(4):924-9. PubMed PMID: 16361289.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The association between polycystic ovaries and endometrial cancer. AU - Pillay,O C, AU - Te Fong,L F Wong, AU - Crow,J C, AU - Benjamin,E, AU - Mould,T, AU - Atiomo,W, AU - Menon,P A, AU - Leonard,A J, AU - Hardiman,P, Y1 - 2005/12/16/ PY - 2005/12/20/pubmed PY - 2006/6/6/medline PY - 2005/12/20/entrez SP - 924 EP - 9 JF - Human reproduction (Oxford, England) JO - Hum. Reprod. VL - 21 IS - 4 N2 - BACKGROUND: Women with polycystic ovary syndrome (PCOS) are assumed to be at increased risk of endometrial cancer (EC), albeit of a more differentiated type with better prognosis than in normal women. This study was designed to test these assumptions, as evidence for them is lacking. METHODS: The prevalence of polycystic ovaries (PCO), as a marker of PCOS, was investigated in ovarian sections from 128 women with EC and 83 with benign gynaecological conditions. The expression of the prognostic markers p53, Ki67, Bcl2 and cyclin D1 was also investigated by immunohistochemistry in endometrial tumours from 11 women with PCO and 16 with normal ovaries. RESULTS: Overall, PCO were similarly prevalent in women with EC (8.6%) and benign controls (8.4%); however, in women aged <50 years, PCO were more prevalent in women with EC (62.5 versus 27.3%, P = 0.033). Cyclin D1-expressing endometrial tumours tended to be more prevalent in women with PCO compared to normal ovaries (36.4 versus 6.25%, respectively, P = 0.071). Bcl2-, p53- and Ki67-expressing tumours were similarly prevalent. CONCLUSIONS: The association between PCOS and EC appears confined to premenopausal women. The tendency for cyclin D1-expressing endometrial tumours to be more prevalent in women with PCO challenges the assumption that EC prognosis is improved in women with PCOS. SN - 0268-1161 UR - https://www.unboundmedicine.com/medline/citation/16361289/The_association_between_polycystic_ovaries_and_endometrial_cancer_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/dei420 DB - PRIME DP - Unbound Medicine ER -