Tags

Type your tag names separated by a space and hit enter

The association between polycystic ovaries and endometrial cancer.
Hum Reprod 2006; 21(4):924-9HR

Abstract

BACKGROUND

Women with polycystic ovary syndrome (PCOS) are assumed to be at increased risk of endometrial cancer (EC), albeit of a more differentiated type with better prognosis than in normal women. This study was designed to test these assumptions, as evidence for them is lacking.

METHODS

The prevalence of polycystic ovaries (PCO), as a marker of PCOS, was investigated in ovarian sections from 128 women with EC and 83 with benign gynaecological conditions. The expression of the prognostic markers p53, Ki67, Bcl2 and cyclin D1 was also investigated by immunohistochemistry in endometrial tumours from 11 women with PCO and 16 with normal ovaries.

RESULTS

Overall, PCO were similarly prevalent in women with EC (8.6%) and benign controls (8.4%); however, in women aged <50 years, PCO were more prevalent in women with EC (62.5 versus 27.3%, P = 0.033). Cyclin D1-expressing endometrial tumours tended to be more prevalent in women with PCO compared to normal ovaries (36.4 versus 6.25%, respectively, P = 0.071). Bcl2-, p53- and Ki67-expressing tumours were similarly prevalent.

CONCLUSIONS

The association between PCOS and EC appears confined to premenopausal women. The tendency for cyclin D1-expressing endometrial tumours to be more prevalent in women with PCO challenges the assumption that EC prognosis is improved in women with PCOS.

Authors+Show Affiliations

University Department of Obstetrics and Gynaecology, Royal Free and University College Medical School, University College London, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16361289

Citation

Pillay, O C., et al. "The Association Between Polycystic Ovaries and Endometrial Cancer." Human Reproduction (Oxford, England), vol. 21, no. 4, 2006, pp. 924-9.
Pillay OC, Te Fong LF, Crow JC, et al. The association between polycystic ovaries and endometrial cancer. Hum Reprod. 2006;21(4):924-9.
Pillay, O. C., Te Fong, L. F., Crow, J. C., Benjamin, E., Mould, T., Atiomo, W., ... Hardiman, P. (2006). The association between polycystic ovaries and endometrial cancer. Human Reproduction (Oxford, England), 21(4), pp. 924-9.
Pillay OC, et al. The Association Between Polycystic Ovaries and Endometrial Cancer. Hum Reprod. 2006;21(4):924-9. PubMed PMID: 16361289.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between polycystic ovaries and endometrial cancer. AU - Pillay,O C, AU - Te Fong,L F Wong, AU - Crow,J C, AU - Benjamin,E, AU - Mould,T, AU - Atiomo,W, AU - Menon,P A, AU - Leonard,A J, AU - Hardiman,P, Y1 - 2005/12/16/ PY - 2005/12/20/pubmed PY - 2006/6/6/medline PY - 2005/12/20/entrez SP - 924 EP - 9 JF - Human reproduction (Oxford, England) JO - Hum. Reprod. VL - 21 IS - 4 N2 - BACKGROUND: Women with polycystic ovary syndrome (PCOS) are assumed to be at increased risk of endometrial cancer (EC), albeit of a more differentiated type with better prognosis than in normal women. This study was designed to test these assumptions, as evidence for them is lacking. METHODS: The prevalence of polycystic ovaries (PCO), as a marker of PCOS, was investigated in ovarian sections from 128 women with EC and 83 with benign gynaecological conditions. The expression of the prognostic markers p53, Ki67, Bcl2 and cyclin D1 was also investigated by immunohistochemistry in endometrial tumours from 11 women with PCO and 16 with normal ovaries. RESULTS: Overall, PCO were similarly prevalent in women with EC (8.6%) and benign controls (8.4%); however, in women aged <50 years, PCO were more prevalent in women with EC (62.5 versus 27.3%, P = 0.033). Cyclin D1-expressing endometrial tumours tended to be more prevalent in women with PCO compared to normal ovaries (36.4 versus 6.25%, respectively, P = 0.071). Bcl2-, p53- and Ki67-expressing tumours were similarly prevalent. CONCLUSIONS: The association between PCOS and EC appears confined to premenopausal women. The tendency for cyclin D1-expressing endometrial tumours to be more prevalent in women with PCO challenges the assumption that EC prognosis is improved in women with PCOS. SN - 0268-1161 UR - https://www.unboundmedicine.com/medline/citation/16361289/The_association_between_polycystic_ovaries_and_endometrial_cancer_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/dei420 DB - PRIME DP - Unbound Medicine ER -