Tags

Type your tag names separated by a space and hit enter

Women with synchronous primary cancers of the endometrium and ovary: do they have Lynch syndrome?
J Clin Oncol 2005; 23(36):9344-50JC

Abstract

PURPOSE

Lynch syndrome (hereditary nonpolyposis colorectal cancer; HNPCC) is an autosomal-dominant cancer predisposition syndrome that increases risk for multiple cancers, including colon, endometrial, and ovarian cancer. Revised Bethesda Criteria recommend that patients with two HNPCC-associated cancers undergo molecular evaluation to determine whether they have a mismatch repair (MMR) defect associated with HNPCC. The purpose of our study was to determine the likelihood of MMR defects (MSH2, MSH6, MLH1) in women with synchronous endometrial and ovarian cancer.

PATIENTS AND METHODS

Between 1989 and 2004, 102 women with synchronous endometrial and ovarian cancers were identified; 59 patients had tumor blocks available for analysis. Patients were divided into risk groups based on family history: high (met Amsterdam criteria), medium (personal history or first-degree relative with an HNPCC-associated cancer), and low (all others). Protein expression for MSH2, MSH6, and MLH1 was evaluated by immunohistochemistry. Microsatellite instability and MLH1 promoter methylation analyses were performed on a subset of cases.

RESULTS

Median age was 50 years. Two patients met Amsterdam criteria for HNPCC. Five additional patients, all medium-risk, had molecular findings consistent with a germline mutation of either MSH2 or MLH1. None of the low-risk patients had molecular results consistent with a germline mutation.

CONCLUSION

Overall, 7% of women in our cohort met either clinical or molecular criteria for Lynch syndrome. All of these women had a prior history or a first-degree relative with an HNPCC-associated cancer. Limiting genetic evaluation to women with synchronous endometrial and ovarian cancer who have a family history suggestive of HNPCC may appropriately identify women with Lynch syndrome.

Authors+Show Affiliations

Department of Gynecologic Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16361634

Citation

Soliman, Pamela T., et al. "Women With Synchronous Primary Cancers of the Endometrium and Ovary: Do They Have Lynch Syndrome?" Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, vol. 23, no. 36, 2005, pp. 9344-50.
Soliman PT, Broaddus RR, Schmeler KM, et al. Women with synchronous primary cancers of the endometrium and ovary: do they have Lynch syndrome? J Clin Oncol. 2005;23(36):9344-50.
Soliman, P. T., Broaddus, R. R., Schmeler, K. M., Daniels, M. S., Gonzalez, D., Slomovitz, B. M., ... Lu, K. H. (2005). Women with synchronous primary cancers of the endometrium and ovary: do they have Lynch syndrome? Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 23(36), pp. 9344-50.
Soliman PT, et al. Women With Synchronous Primary Cancers of the Endometrium and Ovary: Do They Have Lynch Syndrome. J Clin Oncol. 2005 Dec 20;23(36):9344-50. PubMed PMID: 16361634.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Women with synchronous primary cancers of the endometrium and ovary: do they have Lynch syndrome? AU - Soliman,Pamela T, AU - Broaddus,Russell R, AU - Schmeler,Kathleen M, AU - Daniels,Molly S, AU - Gonzalez,Delia, AU - Slomovitz,Brian M, AU - Gershenson,David M, AU - Lu,Karen H, PY - 2005/12/20/pubmed PY - 2006/2/4/medline PY - 2005/12/20/entrez SP - 9344 EP - 50 JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology JO - J. Clin. Oncol. VL - 23 IS - 36 N2 - PURPOSE: Lynch syndrome (hereditary nonpolyposis colorectal cancer; HNPCC) is an autosomal-dominant cancer predisposition syndrome that increases risk for multiple cancers, including colon, endometrial, and ovarian cancer. Revised Bethesda Criteria recommend that patients with two HNPCC-associated cancers undergo molecular evaluation to determine whether they have a mismatch repair (MMR) defect associated with HNPCC. The purpose of our study was to determine the likelihood of MMR defects (MSH2, MSH6, MLH1) in women with synchronous endometrial and ovarian cancer. PATIENTS AND METHODS: Between 1989 and 2004, 102 women with synchronous endometrial and ovarian cancers were identified; 59 patients had tumor blocks available for analysis. Patients were divided into risk groups based on family history: high (met Amsterdam criteria), medium (personal history or first-degree relative with an HNPCC-associated cancer), and low (all others). Protein expression for MSH2, MSH6, and MLH1 was evaluated by immunohistochemistry. Microsatellite instability and MLH1 promoter methylation analyses were performed on a subset of cases. RESULTS: Median age was 50 years. Two patients met Amsterdam criteria for HNPCC. Five additional patients, all medium-risk, had molecular findings consistent with a germline mutation of either MSH2 or MLH1. None of the low-risk patients had molecular results consistent with a germline mutation. CONCLUSION: Overall, 7% of women in our cohort met either clinical or molecular criteria for Lynch syndrome. All of these women had a prior history or a first-degree relative with an HNPCC-associated cancer. Limiting genetic evaluation to women with synchronous endometrial and ovarian cancer who have a family history suggestive of HNPCC may appropriately identify women with Lynch syndrome. SN - 0732-183X UR - https://www.unboundmedicine.com/medline/citation/16361634/Women_with_synchronous_primary_cancers_of_the_endometrium_and_ovary:_do_they_have_Lynch_syndrome L2 - http://ascopubs.org/doi/full/10.1200/JCO.2005.03.5915?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -