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Age related macular degeneration and sun exposure, iris colour, and skin sensitivity to sunlight.
Br J Ophthalmol. 2006 Jan; 90(1):29-32.BJ

Abstract

BACKGROUND/AIM

It has been suggested that sun exposure may be a risk factor for age related macular degeneration (AMD) and that skin sensitivity to sunlight and iris colour could be confounding factors. The aim was to investigate this further in the white population.

METHODS

446 cases with end stage AMD were compared with 283 spouse controls. Data on sun exposure, places of residence, iris colour, subjective assessment of change in iris colour, hair colour at age 20, and skin sensitivity were obtained using a questionnaire. Iris colour was graded clinically by comparison with standard photographs. AMD was graded using stereoscopic colour fundus photographs as well as clinical examination and was defined as the presence of geographic atrophy or choroidal neovascularisation. All variables were included in a multiple logistic regression model including age, sex, and smoking.

RESULTS

There was no association between AMD and sun exposure or related factors except for the suggestion of an association between sunburn prone skin type and geographic atrophy which reached borderline significance.

CONCLUSIONS

No significant association between AMD and sun exposure, iris colour, change in iris colour, or hair colour was demonstrated.

Authors+Show Affiliations

Department of Medical Genetics, University of Cambridge, Cambridge CB2 2QQ, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16361662

Citation

Khan, J C., et al. "Age Related Macular Degeneration and Sun Exposure, Iris Colour, and Skin Sensitivity to Sunlight." The British Journal of Ophthalmology, vol. 90, no. 1, 2006, pp. 29-32.
Khan JC, Shahid H, Thurlby DA, et al. Age related macular degeneration and sun exposure, iris colour, and skin sensitivity to sunlight. Br J Ophthalmol. 2006;90(1):29-32.
Khan, J. C., Shahid, H., Thurlby, D. A., Bradley, M., Clayton, D. G., Moore, A. T., Bird, A. C., & Yates, J. R. (2006). Age related macular degeneration and sun exposure, iris colour, and skin sensitivity to sunlight. The British Journal of Ophthalmology, 90(1), 29-32.
Khan JC, et al. Age Related Macular Degeneration and Sun Exposure, Iris Colour, and Skin Sensitivity to Sunlight. Br J Ophthalmol. 2006;90(1):29-32. PubMed PMID: 16361662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age related macular degeneration and sun exposure, iris colour, and skin sensitivity to sunlight. AU - Khan,J C, AU - Shahid,H, AU - Thurlby,D A, AU - Bradley,M, AU - Clayton,D G, AU - Moore,A T, AU - Bird,A C, AU - Yates,J R W, AU - ,, PY - 2005/12/20/pubmed PY - 2006/1/24/medline PY - 2005/12/20/entrez SP - 29 EP - 32 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 90 IS - 1 N2 - BACKGROUND/AIM: It has been suggested that sun exposure may be a risk factor for age related macular degeneration (AMD) and that skin sensitivity to sunlight and iris colour could be confounding factors. The aim was to investigate this further in the white population. METHODS: 446 cases with end stage AMD were compared with 283 spouse controls. Data on sun exposure, places of residence, iris colour, subjective assessment of change in iris colour, hair colour at age 20, and skin sensitivity were obtained using a questionnaire. Iris colour was graded clinically by comparison with standard photographs. AMD was graded using stereoscopic colour fundus photographs as well as clinical examination and was defined as the presence of geographic atrophy or choroidal neovascularisation. All variables were included in a multiple logistic regression model including age, sex, and smoking. RESULTS: There was no association between AMD and sun exposure or related factors except for the suggestion of an association between sunburn prone skin type and geographic atrophy which reached borderline significance. CONCLUSIONS: No significant association between AMD and sun exposure, iris colour, change in iris colour, or hair colour was demonstrated. SN - 0007-1161 UR - https://www.unboundmedicine.com/medline/citation/16361662/Age_related_macular_degeneration_and_sun_exposure_iris_colour_and_skin_sensitivity_to_sunlight_ L2 - https://bjo.bmj.com/lookup/pmidlookup?view=long&pmid=16361662 DB - PRIME DP - Unbound Medicine ER -