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Toxicology and carcinogenesis studies of sodium chlorate (Cas No. 7775-09-9) in F344/N rats and B6C3F1 mice (drinking water studies).

Abstract

BACKGROUND

Sodium chlorate occurs when drinking water is disinfected by chlorine dioxide. We studied the effects of sodium chlorate in rats and mice to identify potential toxic or carcinogenic hazards to humans.

METHODS

We gave groups of male and female rats drinking water containing 125, 1,000, or 2,000 milligrams (mg) of sodium chlorate per liter (L) of water for two years. Male and female mice received 500, 1,000, or 2,000 mg/L. Other groups of animals received plain tap water and served as the control groups. At the end of the study, tissues from more than 40 sites were examined for every animal.

RESULTS

Male and female rats receiving sodium chlorate had higher rates of follicular cell hypertrophy of the thyroid gland, and the groups receiving 2,000 mg/L had higher rates of thyroid gland cancer, compared with the control groups. Female mice exposed to sodium chlorate had a few pancreatic islet cell tumors.

CONCLUSIONS

We conclude that sodium chlorate caused some thyroid gland neoplasms in male and female rats. The pancreatic islet cell tumors in female mice may have been related to sodium chlorate exposure.

Authors

No affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16362061

Citation

National Toxicology Program. "Toxicology and Carcinogenesis Studies of Sodium Chlorate (Cas No. 7775-09-9) in F344/N Rats and B6C3F1 Mice (drinking Water Studies)." National Toxicology Program Technical Report Series, 2005, pp. 1-255.
National Toxicology Program. Toxicology and carcinogenesis studies of sodium chlorate (Cas No. 7775-09-9) in F344/N rats and B6C3F1 mice (drinking water studies). Natl Toxicol Program Tech Rep Ser. 2005.
National Toxicology Program. (2005). Toxicology and carcinogenesis studies of sodium chlorate (Cas No. 7775-09-9) in F344/N rats and B6C3F1 mice (drinking water studies). National Toxicology Program Technical Report Series, (517), 1-255.
National Toxicology Program. Toxicology and Carcinogenesis Studies of Sodium Chlorate (Cas No. 7775-09-9) in F344/N Rats and B6C3F1 Mice (drinking Water Studies). Natl Toxicol Program Tech Rep Ser. 2005;(517)1-255. PubMed PMID: 16362061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toxicology and carcinogenesis studies of sodium chlorate (Cas No. 7775-09-9) in F344/N rats and B6C3F1 mice (drinking water studies). A1 - ,, PY - 2005/12/20/pubmed PY - 2006/5/12/medline PY - 2005/12/20/entrez SP - 1 EP - 255 JF - National Toxicology Program technical report series JO - Natl Toxicol Program Tech Rep Ser IS - 517 N2 - BACKGROUND: Sodium chlorate occurs when drinking water is disinfected by chlorine dioxide. We studied the effects of sodium chlorate in rats and mice to identify potential toxic or carcinogenic hazards to humans. METHODS: We gave groups of male and female rats drinking water containing 125, 1,000, or 2,000 milligrams (mg) of sodium chlorate per liter (L) of water for two years. Male and female mice received 500, 1,000, or 2,000 mg/L. Other groups of animals received plain tap water and served as the control groups. At the end of the study, tissues from more than 40 sites were examined for every animal. RESULTS: Male and female rats receiving sodium chlorate had higher rates of follicular cell hypertrophy of the thyroid gland, and the groups receiving 2,000 mg/L had higher rates of thyroid gland cancer, compared with the control groups. Female mice exposed to sodium chlorate had a few pancreatic islet cell tumors. CONCLUSIONS: We conclude that sodium chlorate caused some thyroid gland neoplasms in male and female rats. The pancreatic islet cell tumors in female mice may have been related to sodium chlorate exposure. SN - 0888-8051 UR - https://www.unboundmedicine.com/medline/citation/16362061/Toxicology_and_carcinogenesis_studies_of_sodium_chlorate__Cas_No__7775_09_9__in_F344/N_rats_and_B6C3F1_mice__drinking_water_studies__ DB - PRIME DP - Unbound Medicine ER -