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Cytokines and heart rate variability in patients with chronic heart failure.
Kardiol Pol. 2005 Nov; 63(5):478-85; discussion 486-7.KP

Abstract

INTRODUCTION

Heart rate variability (HRV) analysis is a non-invasive method of assessment of the autonomic nervous system's effects on heart function. In chronic heart failure (CHF), decreased HRV correlates with the progression of the disease. It is also known that in CHF increased levels of proinflammatory cytokines are present. Because these molecules are believed to influence the nervous system at both the central and peripheral levels, their potential role in HRV reduction in the course of CHF has been proposed.

AIM

The study was designed to verify potential relations between cytokines and HRV parameters in CHF patients. The concept of the study was driven by the recognition of controversies in this field and the paucity of published reports.

METHODS

Forty-four patients with CHF and stable NYHA class I-IV symptoms and 15 healthy controls were enrolled in the study. Time-domain HRV analysis was performed based on of 24-hour Holter ECG monitoring. Plasma concentrations of soluble TNFalpha receptors sTNF-RI and sTNF-RII and interleukin 6 (IL-6) were measured using commercially available ELISA kits (Quantikine, RD Systems).

RESULTS

In patients with CHF, HRV indices included in the analysis were significantly decreased, and the levels of cytokines increased in comparison with the control group. In the whole study population, both in the CHF patients and the control group, significant negative correlations were observed between sTNF-RI level and long-term HRV indices such as SDNN (r=-0.44; p=0.0006), SDANN (r=-0.44; p=0.0005) and short-time index SDNNI (r=-0.37; p=0.004). Similar negative correlations were found between sTNF-RII level and SDNN (r=-0.35; p=0.007), SDANN (r=-0.34; p=0.01), and SDNNI (r=-0.31; p=0.02), as well as between IL-6 level and SDNN (r=-0.41; p=0.001), SDANN (r=-0.44; p=0.0005) and SDNNI (r=-0.34; p=0.009).

CONCLUSIONS

Significant negative correlations between TNF-alpha soluble receptors sTNF-RI, sTNF-RII and IL-6 levels and time-domain HRV parameters were observed in the study. Because the results of investigations conducted so far do not elucidate the cause-effect relationship, further studies are needed to clarify the mechanisms of HRV depression in CHF and the role of cytokines in this severe clinical condition.

Authors+Show Affiliations

I Klinika Kardiologii, Katedra Kardiologii Akademii Medycznej, ul. Długa 1/2, 61-848 Poznań. ewa.migaj-straburzynska@sk1.am.poznan.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

16362851

Citation

Straburzyńska-Migaj, Ewa, et al. "Cytokines and Heart Rate Variability in Patients With Chronic Heart Failure." Kardiologia Polska, vol. 63, no. 5, 2005, pp. 478-85; discussion 486-7.
Straburzyńska-Migaj E, Ochotny R, Wachowiak-Baszyńska A, et al. Cytokines and heart rate variability in patients with chronic heart failure. Kardiol Pol. 2005;63(5):478-85; discussion 486-7.
Straburzyńska-Migaj, E., Ochotny, R., Wachowiak-Baszyńska, A., Straburzyńska-Lupa, A., Leśniewska, K., Wiktorowicz, K., & Cieśliński, A. (2005). Cytokines and heart rate variability in patients with chronic heart failure. Kardiologia Polska, 63(5), 478-85; discussion 486-7.
Straburzyńska-Migaj E, et al. Cytokines and Heart Rate Variability in Patients With Chronic Heart Failure. Kardiol Pol. 2005;63(5):478-85; discussion 486-7. PubMed PMID: 16362851.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytokines and heart rate variability in patients with chronic heart failure. AU - Straburzyńska-Migaj,Ewa, AU - Ochotny,Romuald, AU - Wachowiak-Baszyńska,Anna, AU - Straburzyńska-Lupa,Anna, AU - Leśniewska,Kinga, AU - Wiktorowicz,Krzysztof, AU - Cieśliński,Andrzej, PY - 2005/12/20/pubmed PY - 2006/6/29/medline PY - 2005/12/20/entrez SP - 478-85; discussion 486-7 JF - Kardiologia polska JO - Kardiol Pol VL - 63 IS - 5 N2 - INTRODUCTION: Heart rate variability (HRV) analysis is a non-invasive method of assessment of the autonomic nervous system's effects on heart function. In chronic heart failure (CHF), decreased HRV correlates with the progression of the disease. It is also known that in CHF increased levels of proinflammatory cytokines are present. Because these molecules are believed to influence the nervous system at both the central and peripheral levels, their potential role in HRV reduction in the course of CHF has been proposed. AIM: The study was designed to verify potential relations between cytokines and HRV parameters in CHF patients. The concept of the study was driven by the recognition of controversies in this field and the paucity of published reports. METHODS: Forty-four patients with CHF and stable NYHA class I-IV symptoms and 15 healthy controls were enrolled in the study. Time-domain HRV analysis was performed based on of 24-hour Holter ECG monitoring. Plasma concentrations of soluble TNFalpha receptors sTNF-RI and sTNF-RII and interleukin 6 (IL-6) were measured using commercially available ELISA kits (Quantikine, RD Systems). RESULTS: In patients with CHF, HRV indices included in the analysis were significantly decreased, and the levels of cytokines increased in comparison with the control group. In the whole study population, both in the CHF patients and the control group, significant negative correlations were observed between sTNF-RI level and long-term HRV indices such as SDNN (r=-0.44; p=0.0006), SDANN (r=-0.44; p=0.0005) and short-time index SDNNI (r=-0.37; p=0.004). Similar negative correlations were found between sTNF-RII level and SDNN (r=-0.35; p=0.007), SDANN (r=-0.34; p=0.01), and SDNNI (r=-0.31; p=0.02), as well as between IL-6 level and SDNN (r=-0.41; p=0.001), SDANN (r=-0.44; p=0.0005) and SDNNI (r=-0.34; p=0.009). CONCLUSIONS: Significant negative correlations between TNF-alpha soluble receptors sTNF-RI, sTNF-RII and IL-6 levels and time-domain HRV parameters were observed in the study. Because the results of investigations conducted so far do not elucidate the cause-effect relationship, further studies are needed to clarify the mechanisms of HRV depression in CHF and the role of cytokines in this severe clinical condition. SN - 0022-9032 UR - https://www.unboundmedicine.com/medline/citation/16362851/Cytokines_and_heart_rate_variability_in_patients_with_chronic_heart_failure_ L2 - https://medlineplus.gov/heartfailure.html DB - PRIME DP - Unbound Medicine ER -