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Exposures to silica mixed dust and cohort mortality study in tin mines: exposure-response analysis and risk assessment of lung cancer.
Am J Ind Med 2006; 49(2):67-76AJ

Abstract

BACKGROUND

Mineral dusts that contain crystalline silica have been associated directly or indirectly with the development of pneumoconiosis or silicosis, non-malignant respiratory diseases, lung cancer, and other diseases. The health impacts on workers with silica mixed dust exposure in tin mines and dose-response relationships between cumulative dust exposure and the mortality from lung cancer are investigated.

METHODS

A cohort of 7,837 workers registered in the employment records in 4 Chinese tin mines between 1972 and 1974 was identified for this study and the mortality follow-up was traced through 1994. Of the cohort, the cause of death was ascertained for 1,061 (97%) of the 1,094 deceased workers. Standardized mortality ratios (SMRs) were calculated for all workers, non-exposed workers, and dust-exposed workers with different exposure levels, silicotics, and non-silicotics based on Chinese national rates.

RESULTS

The mortality from all causes in four tin mines was nearly the same as the national mortality. Malignant neoplasm, cerebrovascular disease, and cardiovascular disease accounted for 68.6% of all deaths. Mortality excess from lung cancer, liver cancer, all malignant diseases, and non-malignant respiratory diseases was observed among dust-exposed workers; a 50-fold excess of pneumoconiosis was observed. There was an upward trend for SMRs of lung cancer was noted from no exposure to low, medium, and high exposure levels (SMRs=1.29, 2.65, 2.66, 3.33). The shape of the exposure-response curve for risk of lung cancer at high exposure levels was inconsistent in these four mines.

CONCLUSIONS

The findings indicated a positive dose-response relation between exposure to cumulative dust and the mortality of lung cancer. High arsenic content in dust particles, together with crystalline silica, may play an important role in causing increased mortality from lung cancer.

Authors+Show Affiliations

Department of Occupational and Environmental Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. wchen@mails.tjmu.edu.cnNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16362950

Citation

Chen, Weihong, et al. "Exposures to Silica Mixed Dust and Cohort Mortality Study in Tin Mines: Exposure-response Analysis and Risk Assessment of Lung Cancer." American Journal of Industrial Medicine, vol. 49, no. 2, 2006, pp. 67-76.
Chen W, Yang J, Chen J, et al. Exposures to silica mixed dust and cohort mortality study in tin mines: exposure-response analysis and risk assessment of lung cancer. Am J Ind Med. 2006;49(2):67-76.
Chen, W., Yang, J., Chen, J., & Bruch, J. (2006). Exposures to silica mixed dust and cohort mortality study in tin mines: exposure-response analysis and risk assessment of lung cancer. American Journal of Industrial Medicine, 49(2), pp. 67-76.
Chen W, et al. Exposures to Silica Mixed Dust and Cohort Mortality Study in Tin Mines: Exposure-response Analysis and Risk Assessment of Lung Cancer. Am J Ind Med. 2006;49(2):67-76. PubMed PMID: 16362950.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exposures to silica mixed dust and cohort mortality study in tin mines: exposure-response analysis and risk assessment of lung cancer. AU - Chen,Weihong, AU - Yang,Jian, AU - Chen,Jingqiong, AU - Bruch,Joachim, PY - 2005/12/20/pubmed PY - 2006/5/18/medline PY - 2005/12/20/entrez SP - 67 EP - 76 JF - American journal of industrial medicine JO - Am. J. Ind. Med. VL - 49 IS - 2 N2 - BACKGROUND: Mineral dusts that contain crystalline silica have been associated directly or indirectly with the development of pneumoconiosis or silicosis, non-malignant respiratory diseases, lung cancer, and other diseases. The health impacts on workers with silica mixed dust exposure in tin mines and dose-response relationships between cumulative dust exposure and the mortality from lung cancer are investigated. METHODS: A cohort of 7,837 workers registered in the employment records in 4 Chinese tin mines between 1972 and 1974 was identified for this study and the mortality follow-up was traced through 1994. Of the cohort, the cause of death was ascertained for 1,061 (97%) of the 1,094 deceased workers. Standardized mortality ratios (SMRs) were calculated for all workers, non-exposed workers, and dust-exposed workers with different exposure levels, silicotics, and non-silicotics based on Chinese national rates. RESULTS: The mortality from all causes in four tin mines was nearly the same as the national mortality. Malignant neoplasm, cerebrovascular disease, and cardiovascular disease accounted for 68.6% of all deaths. Mortality excess from lung cancer, liver cancer, all malignant diseases, and non-malignant respiratory diseases was observed among dust-exposed workers; a 50-fold excess of pneumoconiosis was observed. There was an upward trend for SMRs of lung cancer was noted from no exposure to low, medium, and high exposure levels (SMRs=1.29, 2.65, 2.66, 3.33). The shape of the exposure-response curve for risk of lung cancer at high exposure levels was inconsistent in these four mines. CONCLUSIONS: The findings indicated a positive dose-response relation between exposure to cumulative dust and the mortality of lung cancer. High arsenic content in dust particles, together with crystalline silica, may play an important role in causing increased mortality from lung cancer. SN - 0271-3586 UR - https://www.unboundmedicine.com/medline/citation/16362950/Exposures_to_silica_mixed_dust_and_cohort_mortality_study_in_tin_mines:_exposure_response_analysis_and_risk_assessment_of_lung_cancer_ L2 - https://doi.org/10.1002/ajim.20248 DB - PRIME DP - Unbound Medicine ER -