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Few predictors of massive deep vein thrombosis.
Thromb Haemost 2005; 94(5):986-90TH

Abstract

Factors that predispose to thrombus propagation from the femoropopliteal veins to the pelvic veins are poorly understood. Our goal was to determine whether there are characteristics that identify patients with massive deep vein thrombosis (DVT). We compared the 122 (2.5%) patients presenting with massive DVT (pelvic plus lower-extremity DVT) to the 4,674 (97.5%) patients with isolated lower-extremity DVT from a prospective United States multicenter DVT registry. Patients with massive DVT were younger (59.4+/-18.9 years vs. 64.3+/-16.8 years; p<0.01), less likely to have hypertension (40% vs. 51%; p=0.02), and more likely to smoke (21% vs. 13%; p=0.02) and have ongoing radiation therapy (7% vs. 3%; p=0.02). The massive DVT group more commonly presented with extremity edema (80% vs. 69%; p<0.01) and erythema (21% vs. 12%; p<0.01) than the isolated lower-extremity DVT group. However, after multivariable logistic regression analysis, extremity erythema (adjusted odds ratio 1.86; 95% CI 1.13-3.04) was the only independent sequela of massive DVT and younger age (adjusted odds ratio 1.17 per decreasing decade of age; 95% confidence interval: 1.02-1.34) was the only independent predictor of massive DVT. Thrombus propagation from the femoropopliteal system cannot be reliably predicted using demographic or clinical characteristics.

Authors+Show Affiliations

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16363241

Citation

Joffe, Hylton V., et al. "Few Predictors of Massive Deep Vein Thrombosis." Thrombosis and Haemostasis, vol. 94, no. 5, 2005, pp. 986-90.
Joffe HV, Kucher N, Tapson VF, et al. Few predictors of massive deep vein thrombosis. Thromb Haemost. 2005;94(5):986-90.
Joffe, H. V., Kucher, N., Tapson, V. F., & Goldhaber, S. Z. (2005). Few predictors of massive deep vein thrombosis. Thrombosis and Haemostasis, 94(5), pp. 986-90.
Joffe HV, et al. Few Predictors of Massive Deep Vein Thrombosis. Thromb Haemost. 2005;94(5):986-90. PubMed PMID: 16363241.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Few predictors of massive deep vein thrombosis. AU - Joffe,Hylton V, AU - Kucher,Nils, AU - Tapson,Victor F, AU - Goldhaber,Samuel Z, PY - 2005/12/21/pubmed PY - 2006/1/25/medline PY - 2005/12/21/entrez SP - 986 EP - 90 JF - Thrombosis and haemostasis JO - Thromb. Haemost. VL - 94 IS - 5 N2 - Factors that predispose to thrombus propagation from the femoropopliteal veins to the pelvic veins are poorly understood. Our goal was to determine whether there are characteristics that identify patients with massive deep vein thrombosis (DVT). We compared the 122 (2.5%) patients presenting with massive DVT (pelvic plus lower-extremity DVT) to the 4,674 (97.5%) patients with isolated lower-extremity DVT from a prospective United States multicenter DVT registry. Patients with massive DVT were younger (59.4+/-18.9 years vs. 64.3+/-16.8 years; p<0.01), less likely to have hypertension (40% vs. 51%; p=0.02), and more likely to smoke (21% vs. 13%; p=0.02) and have ongoing radiation therapy (7% vs. 3%; p=0.02). The massive DVT group more commonly presented with extremity edema (80% vs. 69%; p<0.01) and erythema (21% vs. 12%; p<0.01) than the isolated lower-extremity DVT group. However, after multivariable logistic regression analysis, extremity erythema (adjusted odds ratio 1.86; 95% CI 1.13-3.04) was the only independent sequela of massive DVT and younger age (adjusted odds ratio 1.17 per decreasing decade of age; 95% confidence interval: 1.02-1.34) was the only independent predictor of massive DVT. Thrombus propagation from the femoropopliteal system cannot be reliably predicted using demographic or clinical characteristics. SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/16363241/Few_predictors_of_massive_deep_vein_thrombosis_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1160/TH05-05-0314 DB - PRIME DP - Unbound Medicine ER -