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The role of type I allergy in secretory otitis media and mast cells in the middle ear mucosa.
Acta Otolaryngol Suppl. 1992; 493:155-63.AO

Abstract

To clarify the role of type I allergy in the etiology and pathogenesis of secretory otitis media (SOM), clinical and experimental studies were done. The distribution of mast cells in the tubotympanum of normal and developing guinea pigs was also investigated. Our clinical study revealed that the ratio of complications of nasal allergy (NA) in 222 SOM-young children is 42%, while that of SOM in 259 NA-young children is 35%. These ratios were significantly higher than those seen in control group which consists of 104-children randomly selected from a kindergarten and elementary school. Findings of our animal experiment showed that the eustachian tube is involved, both functionally and morphologically, in type I allergic reactions of the nose. The tubal dysfunction evoked by nasal allergic reactions was transient, not culminating in middle ear effusion (MEE). However, this dysfunction interferes with the clearance of MEE. Our studies suggest that type I allergic reactions of upper respiratory tracts are factors indicative of a chronic state of disease, rather than a cause of SOM. In adult guinea pigs, the density of mast cells was highest in the pharyngeal orifice of the eustachian tube. The density was higher in the adult than in developing guinea pigs. Mast cells in the middle ear mucosa appeared in areas covered by ciliated epithelia or areas richly vasculized. The results of our investigation suggest that mast cells distribute in the tubotympanum responding to continuous stimuli to the tubotympanic cavity.

Authors+Show Affiliations

Department of Otolaryngology, Medical College of Oita, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1636417

Citation

Mogi, G, et al. "The Role of Type I Allergy in Secretory Otitis Media and Mast Cells in the Middle Ear Mucosa." Acta Oto-laryngologica. Supplementum, vol. 493, 1992, pp. 155-63.
Mogi G, Tomonaga K, Watanabe T, et al. The role of type I allergy in secretory otitis media and mast cells in the middle ear mucosa. Acta Otolaryngol Suppl. 1992;493:155-63.
Mogi, G., Tomonaga, K., Watanabe, T., & Chaen, T. (1992). The role of type I allergy in secretory otitis media and mast cells in the middle ear mucosa. Acta Oto-laryngologica. Supplementum, 493, 155-63.
Mogi G, et al. The Role of Type I Allergy in Secretory Otitis Media and Mast Cells in the Middle Ear Mucosa. Acta Otolaryngol Suppl. 1992;493:155-63. PubMed PMID: 1636417.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of type I allergy in secretory otitis media and mast cells in the middle ear mucosa. AU - Mogi,G, AU - Tomonaga,K, AU - Watanabe,T, AU - Chaen,T, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 155 EP - 63 JF - Acta oto-laryngologica. Supplementum JO - Acta Otolaryngol Suppl VL - 493 N2 - To clarify the role of type I allergy in the etiology and pathogenesis of secretory otitis media (SOM), clinical and experimental studies were done. The distribution of mast cells in the tubotympanum of normal and developing guinea pigs was also investigated. Our clinical study revealed that the ratio of complications of nasal allergy (NA) in 222 SOM-young children is 42%, while that of SOM in 259 NA-young children is 35%. These ratios were significantly higher than those seen in control group which consists of 104-children randomly selected from a kindergarten and elementary school. Findings of our animal experiment showed that the eustachian tube is involved, both functionally and morphologically, in type I allergic reactions of the nose. The tubal dysfunction evoked by nasal allergic reactions was transient, not culminating in middle ear effusion (MEE). However, this dysfunction interferes with the clearance of MEE. Our studies suggest that type I allergic reactions of upper respiratory tracts are factors indicative of a chronic state of disease, rather than a cause of SOM. In adult guinea pigs, the density of mast cells was highest in the pharyngeal orifice of the eustachian tube. The density was higher in the adult than in developing guinea pigs. Mast cells in the middle ear mucosa appeared in areas covered by ciliated epithelia or areas richly vasculized. The results of our investigation suggest that mast cells distribute in the tubotympanum responding to continuous stimuli to the tubotympanic cavity. SN - 0365-5237 UR - https://www.unboundmedicine.com/medline/citation/1636417/The_role_of_type_I_allergy_in_secretory_otitis_media_and_mast_cells_in_the_middle_ear_mucosa_ L2 - https://medlineplus.gov/allergy.html DB - PRIME DP - Unbound Medicine ER -