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Nitric oxide and its modulators in chronic constriction injury-induced neuropathic pain in rats.
Eur J Pharmacol. 2006 Jan 13; 530(1-2):59-69.EJ

Abstract

This study was conducted to examine the role of nitric oxide (NO) in peripheral neuropathy induced by chronic constriction injury of sciatic nerve of rats by using NO precursor, NO donors and nitric oxide synthase (NOS) inhibitors. Chronic constriction injury of sciatic nerve of rats resulted in peripheral neuropathy as confirmed by nociceptive behavioural tests using mechanical, thermal and cold allodynia. NO precursor, L-arginine and NO donors sodium nitroprusside, S-nitroso-N-acetylpenicillamine potentiated the hyperalgesia and allodynia significantly suggesting proalgesic effect in neuropathic rats. Intracerebroventricular (i.c.v.) administration of rats with NOS inhibitors such as L-N(G)-nitroarginine methyl ester, N-iminoethyl lysine and 7-nitroindazole did not show any effect but i.p. administration of NOS inhibitors aminoguanidine, L-N(G)-nitroarginine methyl ester and 7-nitroindazole caused alleviation of pain. The study confirms the involvement of endogenously synthesized and exogenously administered NO in chronic constriction injury-induced neuropathy in rats. Significant increase in the levels of nitrate and nitrite in ligated sciatic nerve suggest that local up regulation of NO in the production and maintenance of neuropathic pain. In conclusion, initial attempt to manipulate L-arginine: NO pathway is indicative of therapeutic potential of these interventions in the management of neuropathic pain.

Authors+Show Affiliations

Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16364289

Citation

Naik, Ajit K., et al. "Nitric Oxide and Its Modulators in Chronic Constriction Injury-induced Neuropathic Pain in Rats." European Journal of Pharmacology, vol. 530, no. 1-2, 2006, pp. 59-69.
Naik AK, Tandan SK, Kumar D, et al. Nitric oxide and its modulators in chronic constriction injury-induced neuropathic pain in rats. Eur J Pharmacol. 2006;530(1-2):59-69.
Naik, A. K., Tandan, S. K., Kumar, D., & Dudhgaonkar, S. P. (2006). Nitric oxide and its modulators in chronic constriction injury-induced neuropathic pain in rats. European Journal of Pharmacology, 530(1-2), 59-69.
Naik AK, et al. Nitric Oxide and Its Modulators in Chronic Constriction Injury-induced Neuropathic Pain in Rats. Eur J Pharmacol. 2006 Jan 13;530(1-2):59-69. PubMed PMID: 16364289.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nitric oxide and its modulators in chronic constriction injury-induced neuropathic pain in rats. AU - Naik,Ajit K, AU - Tandan,Surendra K, AU - Kumar,Dinesh, AU - Dudhgaonkar,Shailesh P, Y1 - 2005/12/20/ PY - 2005/11/10/received PY - 2005/11/14/accepted PY - 2005/12/21/pubmed PY - 2006/3/22/medline PY - 2005/12/21/entrez SP - 59 EP - 69 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 530 IS - 1-2 N2 - This study was conducted to examine the role of nitric oxide (NO) in peripheral neuropathy induced by chronic constriction injury of sciatic nerve of rats by using NO precursor, NO donors and nitric oxide synthase (NOS) inhibitors. Chronic constriction injury of sciatic nerve of rats resulted in peripheral neuropathy as confirmed by nociceptive behavioural tests using mechanical, thermal and cold allodynia. NO precursor, L-arginine and NO donors sodium nitroprusside, S-nitroso-N-acetylpenicillamine potentiated the hyperalgesia and allodynia significantly suggesting proalgesic effect in neuropathic rats. Intracerebroventricular (i.c.v.) administration of rats with NOS inhibitors such as L-N(G)-nitroarginine methyl ester, N-iminoethyl lysine and 7-nitroindazole did not show any effect but i.p. administration of NOS inhibitors aminoguanidine, L-N(G)-nitroarginine methyl ester and 7-nitroindazole caused alleviation of pain. The study confirms the involvement of endogenously synthesized and exogenously administered NO in chronic constriction injury-induced neuropathy in rats. Significant increase in the levels of nitrate and nitrite in ligated sciatic nerve suggest that local up regulation of NO in the production and maintenance of neuropathic pain. In conclusion, initial attempt to manipulate L-arginine: NO pathway is indicative of therapeutic potential of these interventions in the management of neuropathic pain. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/16364289/Nitric_oxide_and_its_modulators_in_chronic_constriction_injury_induced_neuropathic_pain_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(05)01216-1 DB - PRIME DP - Unbound Medicine ER -