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n-6 and n-3 Long-chain polyunsaturated fatty acids in the erythrocyte membrane of Brazilian preterm and term neonates and their mothers at delivery.

Abstract

Placental transfer of the long-chain polyunsaturated fatty acids (LCPUFA) arachidonic (AA) and docosahexaenoic (DHA) acids is selectively high to maintain accretion to fetal tissues, especially the brain. The objectives of the present study were to investigate the essential fatty acid (EFA) and LCPUFA status at birth of preterm and term Brazilian infants and their mothers, from a population of characteristically low intake of n-3 LCPUFA, and to evaluate the association between fetal and maternal status, by the determination of the fatty acid composition of the erythrocyte membrane. Blood samples from umbilical cord of preterm (26-36 weeks of gestation; n = 30) and term (37-42 weeks of gestation; n = 30) infants and the corresponding maternal venous blood were collected at delivery. The LCPUFA composition of the erythrocyte membrane and DHA status were similar for mothers of preterm and term infants. Neonatal AA was higher (P < 0.01) whereas its precursor 18:2n-6 was lower (P < 0.01) than maternal levels, as expected. There was no difference in LCPUFA erythrocyte composition between preterm and term infants, except for DHA. Term infants presented a worse DHA status than preterm infants (P < 0.01) and than their mothers (P < 0.01) at delivery. There was a negative correlation of neonatal DHA with maternal AA and a positive correlation between neonatal AA and maternal AA and 18:2n-6 only at term. These results suggest that the persistent low DHA maternal status, together with the comparatively better AA and 18:2n-6 status, might have affected maternal-fetal transfer of DHA when gestation was completed up to term, and possibly contributed to the worse DHA status of term neonates compared with the preterm neonates.

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  • Authors+Show Affiliations

    ,

    Laboratório de Bioquímica Nutricional e de Alimentos, Instituto de Química, Universidade Federal do Rio de Janeiro, Cidade Universitária, CT bl. A, 21949-900 Rio de Janeiro, RJ, Brazil.

    , , ,

    Source

    MeSH

    Brazil
    Cell Membrane
    Diet
    Erythrocytes
    Fatty Acids, Essential
    Fatty Acids, Omega-3
    Fatty Acids, Omega-6
    Female
    Gestational Age
    Humans
    Infant, Newborn
    Infant, Premature
    Mothers
    Pregnancy

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16364619

    Citation

    Pontes, P V., et al. "N-6 and N-3 Long-chain Polyunsaturated Fatty Acids in the Erythrocyte Membrane of Brazilian Preterm and Term Neonates and Their Mothers at Delivery." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 74, no. 2, 2006, pp. 117-23.
    Pontes PV, Torres AG, Trugo NM, et al. N-6 and n-3 Long-chain polyunsaturated fatty acids in the erythrocyte membrane of Brazilian preterm and term neonates and their mothers at delivery. Prostaglandins Leukot Essent Fatty Acids. 2006;74(2):117-23.
    Pontes, P. V., Torres, A. G., Trugo, N. M., Fonseca, V. M., & Sichieri, R. (2006). N-6 and n-3 Long-chain polyunsaturated fatty acids in the erythrocyte membrane of Brazilian preterm and term neonates and their mothers at delivery. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 74(2), pp. 117-23.
    Pontes PV, et al. N-6 and N-3 Long-chain Polyunsaturated Fatty Acids in the Erythrocyte Membrane of Brazilian Preterm and Term Neonates and Their Mothers at Delivery. Prostaglandins Leukot Essent Fatty Acids. 2006;74(2):117-23. PubMed PMID: 16364619.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - n-6 and n-3 Long-chain polyunsaturated fatty acids in the erythrocyte membrane of Brazilian preterm and term neonates and their mothers at delivery. AU - Pontes,P V, AU - Torres,A G, AU - Trugo,N M F, AU - Fonseca,V M, AU - Sichieri,R, Y1 - 2005/12/20/ PY - 2005/08/18/received PY - 2005/10/18/revised PY - 2005/11/05/accepted PY - 2005/12/21/pubmed PY - 2006/4/7/medline PY - 2005/12/21/entrez SP - 117 EP - 23 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 74 IS - 2 N2 - Placental transfer of the long-chain polyunsaturated fatty acids (LCPUFA) arachidonic (AA) and docosahexaenoic (DHA) acids is selectively high to maintain accretion to fetal tissues, especially the brain. The objectives of the present study were to investigate the essential fatty acid (EFA) and LCPUFA status at birth of preterm and term Brazilian infants and their mothers, from a population of characteristically low intake of n-3 LCPUFA, and to evaluate the association between fetal and maternal status, by the determination of the fatty acid composition of the erythrocyte membrane. Blood samples from umbilical cord of preterm (26-36 weeks of gestation; n = 30) and term (37-42 weeks of gestation; n = 30) infants and the corresponding maternal venous blood were collected at delivery. The LCPUFA composition of the erythrocyte membrane and DHA status were similar for mothers of preterm and term infants. Neonatal AA was higher (P < 0.01) whereas its precursor 18:2n-6 was lower (P < 0.01) than maternal levels, as expected. There was no difference in LCPUFA erythrocyte composition between preterm and term infants, except for DHA. Term infants presented a worse DHA status than preterm infants (P < 0.01) and than their mothers (P < 0.01) at delivery. There was a negative correlation of neonatal DHA with maternal AA and a positive correlation between neonatal AA and maternal AA and 18:2n-6 only at term. These results suggest that the persistent low DHA maternal status, together with the comparatively better AA and 18:2n-6 status, might have affected maternal-fetal transfer of DHA when gestation was completed up to term, and possibly contributed to the worse DHA status of term neonates compared with the preterm neonates. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/16364619/n_6_and_n_3_Long_chain_polyunsaturated_fatty_acids_in_the_erythrocyte_membrane_of_Brazilian_preterm_and_term_neonates_and_their_mothers_at_delivery_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(05)00179-1 DB - PRIME DP - Unbound Medicine ER -