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Regular analgesic use and risk of endometrial cancer.
Cancer Epidemiol Biomarkers Prev 2005; 14(12):2923-8CE

Abstract

BACKGROUND

Analgesic use has been implicated in the chemoprevention of a number of solid tumors, but thus far, no previous research has focused on the role of aspirin in endometrial cancer etiology.

METHODS

We conducted a hospital-based case-control study of 427 women with primary, incident endometrial cancer, and 427 age- and residence-matched controls without benign or malignant neoplasms. All participants received medical services at Roswell Park Cancer Institute in Buffalo, NY, and completed a comprehensive epidemiologic questionnaire. Women who reported analgesic use at least once a week for at least 6 months were classified as regular users and served as the reference group throughout the analyses. We used unconditional logistic regression analyses to compute crude and adjusted odds ratios (OR) with corresponding 95% confidence intervals (CI).

RESULTS

Compared with nonusers, regular aspirin users were not at reduced risk of endometrial cancer (adjusted OR, 0.91; 95% CI, 0.66-1.26), nor were women with the highest frequency, duration, or cumulative lifetime aspirin use. When the sample was divided by body mass index status, regular aspirin use was not associated with risk among women classified as normal weight or overweight, but a significant risk reduction was seen for obese women (adjusted OR, 0.50; 95% CI, 0.27-0.92). Significant decreases in risk were also observed for obese women with the greatest frequency, duration, and cumulative aspirin use. No significant associations in the overall sample or among obese women were noted for acetaminophen use.

CONCLUSION

We observed no evidence of an overall chemoprotective effect of aspirin on endometrial cancer risk, but the significant risk reductions among obese women warrant further investigation.

Authors+Show Affiliations

Department of Epidemiology, Division of Gynecologic Oncology, Roswell Park Cancer Institute, A-316 Carlton House, Elm and Carlton Streets, Buffalo, NY 14263. kirsten.moysich@roswellpark.orgNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16365011

Citation

Moysich, Kirsten B., et al. "Regular Analgesic Use and Risk of Endometrial Cancer." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 14, no. 12, 2005, pp. 2923-8.
Moysich KB, Baker JA, Rodabaugh KJ, et al. Regular analgesic use and risk of endometrial cancer. Cancer Epidemiol Biomarkers Prev. 2005;14(12):2923-8.
Moysich, K. B., Baker, J. A., Rodabaugh, K. J., & Villella, J. A. (2005). Regular analgesic use and risk of endometrial cancer. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 14(12), pp. 2923-8.
Moysich KB, et al. Regular Analgesic Use and Risk of Endometrial Cancer. Cancer Epidemiol Biomarkers Prev. 2005;14(12):2923-8. PubMed PMID: 16365011.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regular analgesic use and risk of endometrial cancer. AU - Moysich,Kirsten B, AU - Baker,Julie A, AU - Rodabaugh,Kerry J, AU - Villella,Jeannine A, PY - 2005/12/21/pubmed PY - 2006/3/1/medline PY - 2005/12/21/entrez SP - 2923 EP - 8 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 14 IS - 12 N2 - BACKGROUND: Analgesic use has been implicated in the chemoprevention of a number of solid tumors, but thus far, no previous research has focused on the role of aspirin in endometrial cancer etiology. METHODS: We conducted a hospital-based case-control study of 427 women with primary, incident endometrial cancer, and 427 age- and residence-matched controls without benign or malignant neoplasms. All participants received medical services at Roswell Park Cancer Institute in Buffalo, NY, and completed a comprehensive epidemiologic questionnaire. Women who reported analgesic use at least once a week for at least 6 months were classified as regular users and served as the reference group throughout the analyses. We used unconditional logistic regression analyses to compute crude and adjusted odds ratios (OR) with corresponding 95% confidence intervals (CI). RESULTS: Compared with nonusers, regular aspirin users were not at reduced risk of endometrial cancer (adjusted OR, 0.91; 95% CI, 0.66-1.26), nor were women with the highest frequency, duration, or cumulative lifetime aspirin use. When the sample was divided by body mass index status, regular aspirin use was not associated with risk among women classified as normal weight or overweight, but a significant risk reduction was seen for obese women (adjusted OR, 0.50; 95% CI, 0.27-0.92). Significant decreases in risk were also observed for obese women with the greatest frequency, duration, and cumulative aspirin use. No significant associations in the overall sample or among obese women were noted for acetaminophen use. CONCLUSION: We observed no evidence of an overall chemoprotective effect of aspirin on endometrial cancer risk, but the significant risk reductions among obese women warrant further investigation. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/16365011/Regular_analgesic_use_and_risk_of_endometrial_cancer_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=16365011 DB - PRIME DP - Unbound Medicine ER -