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Flaxseed oil increases the plasma concentrations of cardioprotective (n-3) fatty acids in humans.
J Nutr 2006; 136(1):83-7JN

Abstract

Alpha-linolenic acid (ALA) is a major dietary (n-3) fatty acid. ALA is converted to longer-chain (n-3) PUFA, such as eicosapentaenoic acid (EPA) and possibly docosahexaenoic acid (DHA). EPA and DHA are fish-based (n-3) fatty acids that have proven cardioprotective properties. We studied the effect of daily supplementation with 3 g of ALA on the plasma concentration of long-chain (n-3) fatty acids in a predominantly African-American population with chronic illness. In a randomized, double-blind trial, 56 participants were given 3 g ALA/d from flaxseed oil capsules (n = 31) or olive oil placebo capsules (n = 25). Plasma EPA levels at 12 wk in the flaxseed oil group increased by 60%, from 24.09 +/- 16.71 to 38.56 +/- 28.92 micromol/L (P = 0.004), whereas no change occurred in the olive oil group. Plasma docosapentaenoic acid (DPA) levels in the flaxseed oil group increased by 25% from 19.94 +/- 9.22 to 27.03 +/- 17.17 micromol/L (P = 0.03) with no change in the olive oil group. Plasma DHA levels did not change in either group. This study demonstrates the efficacy of the conversion of ALA to EPA and DPA in a minority population with chronic disease. ALA may be an alternative to fish oil; however, additional clinical trials with ALA are warranted.

Authors+Show Affiliations

Department of Medicine, Office of Health Promotion and Disease Prevention, Emory University, Atlanta, GA, USA. charper@emory.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16365063

Citation

Harper, Charles R., et al. "Flaxseed Oil Increases the Plasma Concentrations of Cardioprotective (n-3) Fatty Acids in Humans." The Journal of Nutrition, vol. 136, no. 1, 2006, pp. 83-7.
Harper CR, Edwards MJ, DeFilippis AP, et al. Flaxseed oil increases the plasma concentrations of cardioprotective (n-3) fatty acids in humans. J Nutr. 2006;136(1):83-7.
Harper, C. R., Edwards, M. J., DeFilippis, A. P., DeFilipis, A. P., & Jacobson, T. A. (2006). Flaxseed oil increases the plasma concentrations of cardioprotective (n-3) fatty acids in humans. The Journal of Nutrition, 136(1), pp. 83-7.
Harper CR, et al. Flaxseed Oil Increases the Plasma Concentrations of Cardioprotective (n-3) Fatty Acids in Humans. J Nutr. 2006;136(1):83-7. PubMed PMID: 16365063.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flaxseed oil increases the plasma concentrations of cardioprotective (n-3) fatty acids in humans. AU - Harper,Charles R, AU - Edwards,Megan J, AU - DeFilippis,Andrew P, AU - DeFilipis,Andrew P, AU - Jacobson,Terry A, PY - 2005/12/21/pubmed PY - 2006/2/24/medline PY - 2005/12/21/entrez SP - 83 EP - 7 JF - The Journal of nutrition JO - J. Nutr. VL - 136 IS - 1 N2 - Alpha-linolenic acid (ALA) is a major dietary (n-3) fatty acid. ALA is converted to longer-chain (n-3) PUFA, such as eicosapentaenoic acid (EPA) and possibly docosahexaenoic acid (DHA). EPA and DHA are fish-based (n-3) fatty acids that have proven cardioprotective properties. We studied the effect of daily supplementation with 3 g of ALA on the plasma concentration of long-chain (n-3) fatty acids in a predominantly African-American population with chronic illness. In a randomized, double-blind trial, 56 participants were given 3 g ALA/d from flaxseed oil capsules (n = 31) or olive oil placebo capsules (n = 25). Plasma EPA levels at 12 wk in the flaxseed oil group increased by 60%, from 24.09 +/- 16.71 to 38.56 +/- 28.92 micromol/L (P = 0.004), whereas no change occurred in the olive oil group. Plasma docosapentaenoic acid (DPA) levels in the flaxseed oil group increased by 25% from 19.94 +/- 9.22 to 27.03 +/- 17.17 micromol/L (P = 0.03) with no change in the olive oil group. Plasma DHA levels did not change in either group. This study demonstrates the efficacy of the conversion of ALA to EPA and DPA in a minority population with chronic disease. ALA may be an alternative to fish oil; however, additional clinical trials with ALA are warranted. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/16365063/Flaxseed_oil_increases_the_plasma_concentrations_of_cardioprotective__n_3__fatty_acids_in_humans_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/136.1.83 DB - PRIME DP - Unbound Medicine ER -