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Targeted UV-B phototherapy for plaque-type psoriasis.
Arch Dermatol 2005; 141(12):1542-6AD

Abstract

OBJECTIVE

To determine whether targeted UV-B phototherapy is efficacious and safe in the treatment of localized psoriasis and whether there is a dose-response relationship.

DESIGN

Randomized, evaluator-blind, controlled study.

SETTING

Dermatology clinic in a large university-based hospital in Bangkok, Thailand.

PATIENTS

Fourteen patients with stable, localized, plaque-type psoriasis.

INTERVENTIONS

Patients were randomized to receive different fluences of targeted UV-B phototherapy 3 times weekly based on predetermined minimal erythema doses (MEDs). Treatment fluences were constant throughout the study period of 4 weeks. Follow-up was carried out until lesions returned to original state.

MAIN OUTCOME MEASURES

Modified psoriasis area and severity index.

RESULTS

All fluences of UV-B produced some clinical improvement and were very well tolerated. Fluences ranging from 1 to 6 multiples of MEDs resulted in clearance of lesions in some patients with 6 MEDs producing clearance in 77% of patients. The number of treatments required to clear psoriatic lesions when 2 to 6 MEDs were used was 5.0 to 6.1 treatments. The only adverse events observed were erythema, which was asymptomatic in most subjects, and hyperpigmentation.

CONCLUSIONS

Incoherent, targeted UV-B phototherapy is a safe and efficacious treatment modality for localized psoriasis. Its value in other UV-B responsive conditions should be further investigated.

Authors+Show Affiliations

Division of Dermatology, Department of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Rama 4 Road, Bangkok 10330, Thailand. pravit@adsl.loxinfo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16365255

Citation

Asawanonda, Pravit, et al. "Targeted UV-B Phototherapy for Plaque-type Psoriasis." Archives of Dermatology, vol. 141, no. 12, 2005, pp. 1542-6.
Asawanonda P, Chingchai A, Torranin P. Targeted UV-B phototherapy for plaque-type psoriasis. Arch Dermatol. 2005;141(12):1542-6.
Asawanonda, P., Chingchai, A., & Torranin, P. (2005). Targeted UV-B phototherapy for plaque-type psoriasis. Archives of Dermatology, 141(12), pp. 1542-6.
Asawanonda P, Chingchai A, Torranin P. Targeted UV-B Phototherapy for Plaque-type Psoriasis. Arch Dermatol. 2005;141(12):1542-6. PubMed PMID: 16365255.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Targeted UV-B phototherapy for plaque-type psoriasis. AU - Asawanonda,Pravit, AU - Chingchai,Akkrawat, AU - Torranin,Pawinee, PY - 2005/12/21/pubmed PY - 2006/2/24/medline PY - 2005/12/21/entrez SP - 1542 EP - 6 JF - Archives of dermatology JO - Arch Dermatol VL - 141 IS - 12 N2 - OBJECTIVE: To determine whether targeted UV-B phototherapy is efficacious and safe in the treatment of localized psoriasis and whether there is a dose-response relationship. DESIGN: Randomized, evaluator-blind, controlled study. SETTING: Dermatology clinic in a large university-based hospital in Bangkok, Thailand. PATIENTS: Fourteen patients with stable, localized, plaque-type psoriasis. INTERVENTIONS: Patients were randomized to receive different fluences of targeted UV-B phototherapy 3 times weekly based on predetermined minimal erythema doses (MEDs). Treatment fluences were constant throughout the study period of 4 weeks. Follow-up was carried out until lesions returned to original state. MAIN OUTCOME MEASURES: Modified psoriasis area and severity index. RESULTS: All fluences of UV-B produced some clinical improvement and were very well tolerated. Fluences ranging from 1 to 6 multiples of MEDs resulted in clearance of lesions in some patients with 6 MEDs producing clearance in 77% of patients. The number of treatments required to clear psoriatic lesions when 2 to 6 MEDs were used was 5.0 to 6.1 treatments. The only adverse events observed were erythema, which was asymptomatic in most subjects, and hyperpigmentation. CONCLUSIONS: Incoherent, targeted UV-B phototherapy is a safe and efficacious treatment modality for localized psoriasis. Its value in other UV-B responsive conditions should be further investigated. SN - 0003-987X UR - https://www.unboundmedicine.com/medline/citation/16365255/Targeted_UV_B_phototherapy_for_plaque_type_psoriasis_ L2 - https://jamanetwork.com/journals/jamadermatology/fullarticle/10.1001/archderm.141.12.1542 DB - PRIME DP - Unbound Medicine ER -