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Serosal invasion in TNM staging of mass-forming intrahepatic cholangiocarcinoma.
J Hepatobiliary Pancreat Surg. 2005; 12(6):479-83.JH

Abstract

BACKGROUND/PURPOSE

The Liver Cancer Study Group of Japan established a tumor-nodule-metastasis (TNM) staging system for mass-forming intrahepatic cholangiocarcinoma, with T determined by tumor number and size and vascular or serosal invasion. Serosal invasion is not considered in the designation established by the International Union Against Cancer.

METHODS

Sixty-three patients who underwent hepatic resection for mass-forming intrahepatic cholangiocarcinoma were investigated retrospectively, with the investigation including univariate and multivariate analyses of potential prognostic factors.

RESULTS

By log-rank test, tumor size more than 3.0 cm, vascular invasion, lymph node metastasis, intrahepatic metastasis, and involved resection margin, but not serosal invasion, were associated significantly with poor prognosis. Even in patients with serosal invasion, the postoperative outcome was much better in those without than in those with vascular invasion. Multivariate analysis identified vascular invasion, lymph node metastasis, and an involved resection margin as independent prognostic factors. When serosal invasion was excluded from tumor staging, the 5-year survival rates became more clearly stratified: 100% in those with stage I disease, 62% in those with stage II, 25% in those with stage III, and 7% for patients with stage IV.

CONCLUSIONS

Serosal invasion showed no survival impact after hepatic resection for mass-forming intrahepatic cholangiocarcinoma. When serosal invasion was omitted from the TNM staging proposed by the Liver Cancer Study Group of Japan, stratification of postoperative survival between stages was more effective.

Authors+Show Affiliations

Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16365823

Citation

Uenishi, Takahiro, et al. "Serosal Invasion in TNM Staging of Mass-forming Intrahepatic Cholangiocarcinoma." Journal of Hepato-biliary-pancreatic Surgery, vol. 12, no. 6, 2005, pp. 479-83.
Uenishi T, Yamazaki O, Yamamoto T, et al. Serosal invasion in TNM staging of mass-forming intrahepatic cholangiocarcinoma. J Hepatobiliary Pancreat Surg. 2005;12(6):479-83.
Uenishi, T., Yamazaki, O., Yamamoto, T., Hirohashi, K., Tanaka, H., Tanaka, S., Hai, S., & Kubo, S. (2005). Serosal invasion in TNM staging of mass-forming intrahepatic cholangiocarcinoma. Journal of Hepato-biliary-pancreatic Surgery, 12(6), 479-83.
Uenishi T, et al. Serosal Invasion in TNM Staging of Mass-forming Intrahepatic Cholangiocarcinoma. J Hepatobiliary Pancreat Surg. 2005;12(6):479-83. PubMed PMID: 16365823.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serosal invasion in TNM staging of mass-forming intrahepatic cholangiocarcinoma. AU - Uenishi,Takahiro, AU - Yamazaki,Osamu, AU - Yamamoto,Takatsugu, AU - Hirohashi,Kazuhiro, AU - Tanaka,Hiromu, AU - Tanaka,Shogo, AU - Hai,Seikan, AU - Kubo,Shoji, PY - 2005/06/02/received PY - 2005/07/14/accepted PY - 2005/12/21/pubmed PY - 2006/7/11/medline PY - 2005/12/21/entrez SP - 479 EP - 83 JF - Journal of hepato-biliary-pancreatic surgery JO - J Hepatobiliary Pancreat Surg VL - 12 IS - 6 N2 - BACKGROUND/PURPOSE: The Liver Cancer Study Group of Japan established a tumor-nodule-metastasis (TNM) staging system for mass-forming intrahepatic cholangiocarcinoma, with T determined by tumor number and size and vascular or serosal invasion. Serosal invasion is not considered in the designation established by the International Union Against Cancer. METHODS: Sixty-three patients who underwent hepatic resection for mass-forming intrahepatic cholangiocarcinoma were investigated retrospectively, with the investigation including univariate and multivariate analyses of potential prognostic factors. RESULTS: By log-rank test, tumor size more than 3.0 cm, vascular invasion, lymph node metastasis, intrahepatic metastasis, and involved resection margin, but not serosal invasion, were associated significantly with poor prognosis. Even in patients with serosal invasion, the postoperative outcome was much better in those without than in those with vascular invasion. Multivariate analysis identified vascular invasion, lymph node metastasis, and an involved resection margin as independent prognostic factors. When serosal invasion was excluded from tumor staging, the 5-year survival rates became more clearly stratified: 100% in those with stage I disease, 62% in those with stage II, 25% in those with stage III, and 7% for patients with stage IV. CONCLUSIONS: Serosal invasion showed no survival impact after hepatic resection for mass-forming intrahepatic cholangiocarcinoma. When serosal invasion was omitted from the TNM staging proposed by the Liver Cancer Study Group of Japan, stratification of postoperative survival between stages was more effective. SN - 0944-1166 UR - https://www.unboundmedicine.com/medline/citation/16365823/Serosal_invasion_in_TNM_staging_of_mass_forming_intrahepatic_cholangiocarcinoma_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0944-1166&date=2005&volume=12&issue=6&spage=479 DB - PRIME DP - Unbound Medicine ER -