Tags

Type your tag names separated by a space and hit enter

Effects of repeated-dose isradipine on the abuse liability of cocaine.
Exp Clin Psychopharmacol. 2005 Nov; 13(4):319-26.EC

Abstract

Despite preclinical studies suggesting that isradipine may antagonize the abuse liability of cocaine, pretreatment with sustained-release isradipine did not reduce euphoric mood in cocaine-using volunteers. This double-blind, within-subject, crossover laboratory study determined whether maximal dose-loading with isradipine could antagonize effects of cocaine in 12 cocaine-dependent research volunteers administered intravenous cocaine doses (0, 0.325, and 0.65 mg/kg) on different days after 5 days of treatment with isradipine or placebo. Isradipine dose was 30 mg sustained release nightly plus 15 mg immediate release 2 hr before cocaine infusion. Cocaine produced dose-related increases in cocaine's subjective effects and a behavioral measure of reinforcement. Isradipine enhanced, rather than antagonized, subjective effects, indicating that isradipine does not antagonize cocaine's abuse liability in dependent research volunteers.

Authors+Show Affiliations

Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, 78229, USA. roache@uthscsa.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16366762

Citation

Roache, John D., et al. "Effects of Repeated-dose Isradipine On the Abuse Liability of Cocaine." Experimental and Clinical Psychopharmacology, vol. 13, no. 4, 2005, pp. 319-26.
Roache JD, Johnson BA, Ait-Daoud N, et al. Effects of repeated-dose isradipine on the abuse liability of cocaine. Exp Clin Psychopharmacol. 2005;13(4):319-26.
Roache, J. D., Johnson, B. A., Ait-Daoud, N., Mauldin, J. B., Thornton, J. E., Wells, L. T., & Murff, W. L. (2005). Effects of repeated-dose isradipine on the abuse liability of cocaine. Experimental and Clinical Psychopharmacology, 13(4), 319-26.
Roache JD, et al. Effects of Repeated-dose Isradipine On the Abuse Liability of Cocaine. Exp Clin Psychopharmacol. 2005;13(4):319-26. PubMed PMID: 16366762.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of repeated-dose isradipine on the abuse liability of cocaine. AU - Roache,John D, AU - Johnson,Bankole A, AU - Ait-Daoud,Nassima, AU - Mauldin,James B, AU - Thornton,Joe E, AU - Wells,Lynda T, AU - Murff,William L, PY - 2005/12/22/pubmed PY - 2006/3/22/medline PY - 2005/12/22/entrez SP - 319 EP - 26 JF - Experimental and clinical psychopharmacology JO - Exp Clin Psychopharmacol VL - 13 IS - 4 N2 - Despite preclinical studies suggesting that isradipine may antagonize the abuse liability of cocaine, pretreatment with sustained-release isradipine did not reduce euphoric mood in cocaine-using volunteers. This double-blind, within-subject, crossover laboratory study determined whether maximal dose-loading with isradipine could antagonize effects of cocaine in 12 cocaine-dependent research volunteers administered intravenous cocaine doses (0, 0.325, and 0.65 mg/kg) on different days after 5 days of treatment with isradipine or placebo. Isradipine dose was 30 mg sustained release nightly plus 15 mg immediate release 2 hr before cocaine infusion. Cocaine produced dose-related increases in cocaine's subjective effects and a behavioral measure of reinforcement. Isradipine enhanced, rather than antagonized, subjective effects, indicating that isradipine does not antagonize cocaine's abuse liability in dependent research volunteers. SN - 1064-1297 UR - https://www.unboundmedicine.com/medline/citation/16366762/Effects_of_repeated_dose_isradipine_on_the_abuse_liability_of_cocaine_ L2 - http://content.apa.org/journals/pha/13/4/319 DB - PRIME DP - Unbound Medicine ER -